Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in...

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Published in:	Anticancer research Vol. 41; no. 3; pp. 1377 - 1386
Main Authors:	Choi, Jae Hwi, Choi, See Min, Lee, Sin Woo, Jeh, Seong Uk, Hyun, Jae Seog, Lee, Min Ho, Lee, Chunwoo, Kam, Sung Chul, Kim, Dong Chul, Lee, Jong Sil, Hwa, Jeong Seok
Format:	Journal Article
Language:	English
Published:	Greece International Institute of Anticancer Research 01-03-2021
Subjects:	Aged Androgen receptors Cancer surgery Estrogen Receptor alpha - biosynthesis Estrogen Receptor beta - biosynthesis Estrogen receptors Estrogens Humans Immunohistochemistry - methods Male Middle Aged Multivariate Analysis Prostate cancer Prostatectomy Prostatectomy - methods Prostatic Neoplasms - metabolism Prostatic Neoplasms - surgery Receptors Receptors, Androgen - biosynthesis Risk analysis Risk factors SIRT1 protein Sirtuin 1 - biosynthesis Sirtuin 2 - biosynthesis Sirtuin 3 - biosynthesis Tissues α estrogen receptor β estrogen receptor SIRT1 SIRT2 the androgen receptor SIRT3
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Summary:	The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.14895