Gold nanoparticles generated and stabilized by water soluble curcumin–polymer conjugate: Blood compatibility evaluation and targeted drug delivery onto cancer cells
[Display omitted] ► Curcumin conjugated AuNPs were synthesized using hyaluronic acid-curcumin conjugates. ► HA–Cur@AuNPs were further HA–Cur@AuNPs modified with folate conjugated PEG to improve the cancer cell targeting. ► PF.HA–Cur@AuNPs exhibited better dose dependent cytotoxicity toward different...
Saved in:
| Published in: | Journal of colloid and interface science Vol. 368; no. 1; pp. 144 - 151 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Amsterdam
Elsevier Inc
15-02-2012
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | [Display omitted]
► Curcumin conjugated AuNPs were synthesized using hyaluronic acid-curcumin conjugates. ► HA–Cur@AuNPs were further HA–Cur@AuNPs modified with folate conjugated PEG to improve the cancer cell targeting. ► PF.HA–Cur@AuNPs exhibited better dose dependent cytotoxicity toward different cancer cell lines. ► PF.HA–Cur@AuNPs demonstrated enhanced targeting efficacy of 95.4%.
Curcumin (Cur) shows low anticancer activity in vivo due to its reduced systemic bioavailability stemmed from its poor aqueous solubility and instability. Suitably functionalized nanocarriers designed to empty the drug specifically at tumor sites can potentially enhance the antitumor activity of Cur. We devised a simple method for the fabrication of water soluble Cur conjugated gold nanoparticles to target various cancer cell lines. Cur was conjugated to hyaluronic acid (HA) to get a water soluble conjugate (HA–Cur). We generated gold nanoparticles (AuNPs) by reducing chloroauric acid using HA–Cur, which played the dual role of a reducing and stabilizing agent and subsequently anchored folate conjugated PEG. These entities were probed using different analytical techniques, assayed the blood compatibility and cytotoxicity. Their interaction with cancer cell lines (HeLa cells, glyoma cells and Caco 2 cells) was followed by flow cytometry and confocal microscopy. Blood–materials interactions studies showed that the nanoparticles are highly hemocompatible. Flow cytometry and confocal microscopy results showed significant cellular uptake and internalization of the particles by cells. HA–Cur@AuNPs exhibited more cytotoxicity comparing to free Cur. The strategy, we adopted here, resulted the formation blood compatible Cur conjugated AuNPs with enhanced targeting and improved efficacy. |
|---|---|
| AbstractList | Curcumin (Cur) shows low anticancer activity in vivo due to its reduced systemic bioavailability stemmed from its poor aqueous solubility and instability. Suitably functionalized nanocarriers designed to empty the drug specifically at tumor sites can potentially enhance the antitumor activity of Cur. We devised a simple method for the fabrication of water soluble Cur conjugated gold nanoparticles to target various cancer cell lines. Cur was conjugated to hyaluronic acid (HA) to get a water soluble conjugate (HA-Cur). We generated gold nanoparticles (AuNPs) by reducing chloroauric acid using HA-Cur, which played the dual role of a reducing and stabilizing agent and subsequently anchored folate conjugated PEG. These entities were probed using different analytical techniques, assayed the blood compatibility and cytotoxicity. Their interaction with cancer cell lines (HeLa cells, glyoma cells and Caco 2 cells) was followed by flow cytometry and confocal microscopy. Blood-materials interactions studies showed that the nanoparticles are highly hemocompatible. Flow cytometry and confocal microscopy results showed significant cellular uptake and internalization of the particles by cells. HA-Cur@AuNPs exhibited more cytotoxicity comparing to free Cur. The strategy, we adopted here, resulted the formation blood compatible Cur conjugated AuNPs with enhanced targeting and improved efficacy. [Display omitted] ► Curcumin conjugated AuNPs were synthesized using hyaluronic acid-curcumin conjugates. ► HA–Cur@AuNPs were further HA–Cur@AuNPs modified with folate conjugated PEG to improve the cancer cell targeting. ► PF.HA–Cur@AuNPs exhibited better dose dependent cytotoxicity toward different cancer cell lines. ► PF.HA–Cur@AuNPs demonstrated enhanced targeting efficacy of 95.4%. Curcumin (Cur) shows low anticancer activity in vivo due to its reduced systemic bioavailability stemmed from its poor aqueous solubility and instability. Suitably functionalized nanocarriers designed to empty the drug specifically at tumor sites can potentially enhance the antitumor activity of Cur. We devised a simple method for the fabrication of water soluble Cur conjugated gold nanoparticles to target various cancer cell lines. Cur was conjugated to hyaluronic acid (HA) to get a water soluble conjugate (HA–Cur). We generated gold nanoparticles (AuNPs) by reducing chloroauric acid using HA–Cur, which played the dual role of a reducing and stabilizing agent and subsequently anchored folate conjugated PEG. These entities were probed using different analytical techniques, assayed the blood compatibility and cytotoxicity. Their interaction with cancer cell lines (HeLa cells, glyoma cells and Caco 2 cells) was followed by flow cytometry and confocal microscopy. Blood–materials interactions studies showed that the nanoparticles are highly hemocompatible. Flow cytometry and confocal microscopy results showed significant cellular uptake and internalization of the particles by cells. HA–Cur@AuNPs exhibited more cytotoxicity comparing to free Cur. The strategy, we adopted here, resulted the formation blood compatible Cur conjugated AuNPs with enhanced targeting and improved efficacy. Curcumin (Cur) shows low anticancer activity in vivo due to its reduced systemic bioavailability stemmed from its poor aqueous solubility and instability. Suitably functionalized nanocarriers designed to empty the drug specifically at tumor sites can potentially enhance the antitumor activity of Cur. We devised a simple method for the fabrication of water soluble Cur conjugated gold nanoparticles to target various cancer cell lines. Cur was conjugated to hyaluronic acid (HA) to get a water soluble conjugate (HA-Cur). We generated gold nanoparticles (AuNPs) by reducing chloroauric acid using HA-Cur, which played the dual role of a reducing and stabilizing agent and subsequently anchored folate conjugated PEG. These entities were probed using different analytical techniques, assayed the blood compatibility and cytotoxicity. Their interaction with cancer cell lines (HeLa cells, glyoma cells and Caco 2 cells) was followed by flow cytometry and confocal microscopy. Blood-materials interactions studies showed that the nanoparticles are highly hemocompatible. Flow cytometry and confocal microscopy results showed significant cellular uptake and internalization of the particles by cells. HA-CuruNPs exhibited more cytotoxicity comparing to free Cur. The strategy, we adopted here, resulted the formation blood compatible Cur conjugated AuNPs with enhanced targeting and improved efficacy. |
| Author | Sreenivasan, K. Manju, S. |
| Author_xml | – sequence: 1 givenname: S. surname: Manju fullname: Manju, S. – sequence: 2 givenname: K. surname: Sreenivasan fullname: Sreenivasan, K. email: sreeni@sctimst.ac.in |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25697369$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22200330$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc9u1DAQxi1URLeFF-AAviC4ZLGdv664QAUFqRIH6Dly7EnklWMvdrJoe-o78A48GE_ChF16rDSSNePffDOa74yc-OCBkOecrTnj1dvNeqNtWgvG-RqDieIRWXEmy6zmLD8hK8YEz2Qt61NyltKGIViW8gk5FUIwludsRX5fBWeoVz5sVZysdpDoAB6imsBQ5Q1Nk-qss7eYdnv6E-uRpuDmzgHVc9TzaP2fu1_b4PYjfungN_OA1AX94EIwWBi3arKLxrSnsFNuxjT4f-KTigMsk0ycB2rA2R3EPQ1-ClQrrxdBcC49JY975RI8O77n5ObTx--Xn7Prr1dfLt9fZ7ooxJTVDdSs62RXcyGaAnJhjOmaThYNl0Y1steqKqTSvBGq6oxs-lo22pSgNKtylp-T1wfdbQw_ZkhTO9q0bKA8hDm1klelQO0KyTcPkugQa2RTSo6oOKA6hpQi9O022lHFPUILV7WbdnGyXZxsMdBJbHpx1J-7Ecx9y3_rEHh1BFTSyvURz4Ua91xZyTqvJHIvD1yvQquGiMzNN5xUMcbqOhcL8e5AAF52ZyG2SVvA4xsbQU-tCfahTf8Cjo7Mfg |
| CODEN | JCISA5 |
| CitedBy_id | crossref_primary_10_7314_APJCP_2015_16_1_169 crossref_primary_10_1021_jf402894x crossref_primary_10_1016_j_carbpol_2018_08_079 crossref_primary_10_1016_j_ejmech_2019_07_015 crossref_primary_10_1016_j_reactfunctpolym_2016_04_019 crossref_primary_10_1016_j_ijpharm_2015_10_059 crossref_primary_10_1080_1061186X_2019_1599379 crossref_primary_10_1080_08982104_2022_2086567 crossref_primary_10_1016_j_carbpol_2013_08_067 crossref_primary_10_1021_acs_bioconjchem_7b00683 crossref_primary_10_1016_j_msec_2015_11_062 crossref_primary_10_1590_pboci_2023_073 crossref_primary_10_1016_j_jcis_2013_01_001 crossref_primary_10_1039_D0BM00725K crossref_primary_10_1002_ejoc_201500685 crossref_primary_10_3390_polym12030598 crossref_primary_10_4028_www_scientific_net_JNanoR_25_16 crossref_primary_10_1016_j_jtcme_2016_05_005 crossref_primary_10_1016_j_fbio_2023_103446 crossref_primary_10_1016_j_molliq_2013_09_005 crossref_primary_10_1080_09205063_2014_914705 crossref_primary_10_1021_acs_biomac_6b00386 crossref_primary_10_1080_10717544_2022_2092235 crossref_primary_10_3390_pharmaceutics11070301 crossref_primary_10_1039_C4RA08475F crossref_primary_10_1016_j_colsurfb_2019_110525 crossref_primary_10_1155_2017_7351976 crossref_primary_10_3390_biom11030395 crossref_primary_10_1016_j_pharmthera_2021_107871 crossref_primary_10_1016_j_drudis_2018_08_009 crossref_primary_10_1016_j_jddst_2023_104943 crossref_primary_10_1021_acsbiomaterials_7b00390 crossref_primary_10_1016_j_enceco_2021_01_002 crossref_primary_10_1002_chem_202004335 crossref_primary_10_1016_j_mtla_2019_100414 crossref_primary_10_1021_acsanm_0c02946 crossref_primary_10_1007_s10103_018_2538_1 crossref_primary_10_1039_C4TB01731E crossref_primary_10_1088_2053_1591_ab2e4d crossref_primary_10_2174_0929867325666180214102918 crossref_primary_10_1111_jphp_12575 crossref_primary_10_1016_j_jphotobiol_2016_03_056 crossref_primary_10_3390_pharmaceutics11090442 crossref_primary_10_1016_j_cdc_2020_100476 crossref_primary_10_1016_j_ijbiomac_2020_04_175 crossref_primary_10_2147_IJN_S379356 crossref_primary_10_1016_j_jddst_2017_12_008 crossref_primary_10_1016_j_jphotobiol_2019_03_023 crossref_primary_10_1080_03639045_2018_1496451 crossref_primary_10_1039_D2TB02256G crossref_primary_10_1016_j_ijpharm_2018_07_061 crossref_primary_10_1007_s13404_023_00331_5 crossref_primary_10_1016_j_jcis_2014_03_032 crossref_primary_10_1016_j_jcis_2014_09_026 crossref_primary_10_1016_j_jcis_2018_11_028 crossref_primary_10_1039_C4BM00272E crossref_primary_10_3390_biomedicines9101476 crossref_primary_10_1002_macp_202200190 crossref_primary_10_1080_09205063_2017_1412244 crossref_primary_10_1007_s13204_018_0728_6 crossref_primary_10_1039_C3TB21113D crossref_primary_10_3390_cancers14030622 crossref_primary_10_1371_journal_pone_0124955 crossref_primary_10_1016_j_bcab_2023_102906 crossref_primary_10_1155_2014_394264 crossref_primary_10_3390_ph14090939 crossref_primary_10_1016_j_colsurfb_2022_112481 crossref_primary_10_1002_ptr_7389 crossref_primary_10_1007_s12035_016_0136_4 crossref_primary_10_1007_s40005_012_0039_y crossref_primary_10_1038_srep26292 crossref_primary_10_1116_6_0000148 crossref_primary_10_3389_fphar_2021_735446 crossref_primary_10_1038_srep04164 crossref_primary_10_1364_BOE_10_003152 crossref_primary_10_1155_2022_4376960 crossref_primary_10_1021_jf5014692 crossref_primary_10_1049_nbt2_12027 crossref_primary_10_1039_C6CP08607A crossref_primary_10_1089_jmf_2012_0049 crossref_primary_10_1016_j_biomaterials_2013_09_008 crossref_primary_10_1002_macp_201200727 crossref_primary_10_1016_j_matpr_2018_01_086 crossref_primary_10_1039_D3NR06102G crossref_primary_10_1016_j_cis_2015_04_006 crossref_primary_10_2174_1567201819666220408095510 crossref_primary_10_1016_j_pdpdt_2020_102139 crossref_primary_10_1021_acsami_6b16669 crossref_primary_10_1039_D1NH00569C crossref_primary_10_1007_s00432_014_1767_3 crossref_primary_10_1016_j_matpr_2016_11_099 crossref_primary_10_1142_S0219581X23500394 crossref_primary_10_1016_j_ijbiomac_2018_05_051 crossref_primary_10_1208_s12248_015_9811_z crossref_primary_10_15171_apb_2016_044 crossref_primary_10_1016_j_carbpol_2020_117180 crossref_primary_10_1038_s41598_018_21933_6 crossref_primary_10_1039_C6RA21207G crossref_primary_10_1016_j_enmm_2021_100616 crossref_primary_10_1088_2053_1591_3_6_065401 crossref_primary_10_1186_s12645_024_00249_3 crossref_primary_10_1016_j_jconrel_2022_09_058 crossref_primary_10_1016_j_powtec_2014_07_029 crossref_primary_10_1080_14328917_2020_1825770 crossref_primary_10_1016_j_lwt_2015_08_070 crossref_primary_10_33549_physiolres_935187 crossref_primary_10_3389_fnut_2015_00016 crossref_primary_10_3892_ijo_2013_2175 crossref_primary_10_1089_ars_2012_4573 crossref_primary_10_1021_la302168g crossref_primary_10_18632_oncotarget_17484 crossref_primary_10_1208_s12249_016_0644_6 crossref_primary_10_1016_j_carbpol_2015_09_016 crossref_primary_10_1111_jfpe_13246 crossref_primary_10_3390_molecules28104146 crossref_primary_10_1016_j_msec_2012_07_022 crossref_primary_10_1517_17425247_2013_827659 crossref_primary_10_1002_fsn3_1957 crossref_primary_10_1016_j_colsurfb_2022_113029 crossref_primary_10_1039_C3RA45345F crossref_primary_10_1016_j_jddst_2019_06_010 crossref_primary_10_1080_24701556_2020_1870496 crossref_primary_10_1177_1091581820938329 crossref_primary_10_1007_s11051_013_2108_1 crossref_primary_10_1016_j_jcis_2013_10_018 crossref_primary_10_2174_1570180819666220806145656 crossref_primary_10_1016_j_colsurfb_2016_01_038 crossref_primary_10_1186_s43094_021_00281_9 crossref_primary_10_1088_0957_4484_27_32_325101 crossref_primary_10_3390_scipharm86040041 crossref_primary_10_1016_j_ejpb_2014_05_011 crossref_primary_10_1039_c3ra44578j crossref_primary_10_1016_j_msec_2019_03_031 crossref_primary_10_1080_01635581_2017_1285405 crossref_primary_10_1088_2053_1591_aab001 crossref_primary_10_1007_s10238_023_01262_3 crossref_primary_10_1016_j_jconrel_2016_01_018 crossref_primary_10_1016_j_ijpharm_2015_02_038 crossref_primary_10_3390_pharmaceutics14010070 |
| Cites_doi | 10.1016/j.jcis.2011.03.071 10.3109/15419069809004470 10.1021/jm700988f 10.1016/j.ijpharm.2011.02.054 10.1021/mp800051m 10.1021/bc800373x 10.1046/j.1365-2796.1997.00170.x 10.1074/jbc.M410647200 10.1002/ijc.21389 10.1016/j.biomaterials.2010.04.046 10.1021/bc00017a001 10.1007/BF03401744 10.1021/cm050935k 10.1164/rccm.200504-613PP 10.4161/cbt.11.5.14810 10.18433/J30C7D 10.1016/j.carbpol.2004.06.033 10.1023/A:1006170224414 10.1021/nn9011237 10.1021/j150508a015 10.1021/mp800049w 10.1016/j.bcp.2006.02.009 10.1016/j.jconrel.2007.02.011 10.1021/jm100509v 10.1016/S0731-7085(96)02024-9 10.3109/00016488709102833 10.1002/jcp.10186 10.1016/0092-8674(95)90048-9 10.1021/ja075181k 10.1080/10611860902737920 10.1158/1078-0432.CCR-04-0744 10.1021/mp060132k 10.1016/0006-2952(76)90421-4 10.1002/anie.200904359 10.1016/j.canlet.2004.10.051 10.1002/(SICI)1097-4644(1997)27+<26::AID-JCB7>3.0.CO;2-3 |
| ContentType | Journal Article |
| Copyright | 2011 Elsevier Inc. 2015 INIST-CNRS Copyright © 2011 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2011 Elsevier Inc. – notice: 2015 INIST-CNRS – notice: Copyright © 2011 Elsevier Inc. All rights reserved. |
| DBID | FBQ IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U5 8FD L7M 7X8 |
| DOI | 10.1016/j.jcis.2011.11.024 |
| DatabaseName | AGRIS Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Solid State and Superconductivity Abstracts Technology Research Database Advanced Technologies Database with Aerospace MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Technology Research Database Advanced Technologies Database with Aerospace Solid State and Superconductivity Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Technology Research Database MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering Chemistry |
| EISSN | 1095-7103 |
| EndPage | 151 |
| ExternalDocumentID | 10_1016_j_jcis_2011_11_024 22200330 25697369 US201600077329 S0021979711014007 |
| Genre | Evaluation Studies Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 1B1 1~. 1~5 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JN AABNK AABXZ AACTN AAEDT AAEDW AAEPC AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO ABFNM ABFRF ABJNI ABMAC ABNEU ABNUV ABXDB ABXRA ABYKQ ACBEA ACDAQ ACFVG ACGFO ACGFS ACNNM ACRLP ADBBV ADECG ADEWK ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEZYN AFKWA AFRZQ AFTJW AFZHZ AGHFR AGUBO AGYEJ AHHHB AHPOS AIEXJ AIKHN AITUG AIVDX AJBFU AJOXV AJSZI AKURH ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DM4 DU5 EBS EFBJH EFLBG ENUVR EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA HZ~ IHE J1W KOM LG5 LX6 M24 M41 MAGPM MO0 N9A O-L O9- OAUVE OGIMB OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SCC SDF SDG SDP SES SMS SPC SPCBC SPD SSG SSK SSM SSQ SSZ T5K TWZ WH7 XPP YQT ZMT ZU3 ~02 ~G- .GJ 29K 6TJ AAQXK ABPIF ABPTK ADFGL AFFNX AI. ASPBG AVWKF AZFZN BBWZM CAG COF D-I EJD FBQ FEDTE FGOYB G-2 G8K HLY HVGLF H~9 NDZJH NEJ R2- SCB SCE SEW VH1 WUQ XFK ZGI ZXP 08R IQODW AAHBH AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX ABDPE ADVLN AFJKZ CITATION 7U5 8FD L7M 7X8 |
| ID | FETCH-LOGICAL-c442t-78e70bb9b712284e32dddb8b94819da89fca649ac182a6bd98f798cd5eac06303 |
| ISSN | 0021-9797 |
| IngestDate | Fri Oct 25 05:32:13 EDT 2024 Fri Oct 25 09:34:04 EDT 2024 Thu Nov 21 23:11:05 EST 2024 Tue Oct 15 23:44:51 EDT 2024 Sun Oct 29 17:09:27 EDT 2023 Wed Dec 27 19:13:32 EST 2023 Fri Feb 23 02:28:12 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Folic acid conjugated polyethylene glycol Water soluble curcumin Hyaluronic acid Hemocompatibility Gold nanoparticle Water Drug Gold Nanoparticle Solubility Confocal microscopy Polymer Transition metal Blood Design Assay Ethylene oxide polymer Particle Instability |
| Language | English |
| License | CC BY 4.0 Copyright © 2011 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c442t-78e70bb9b712284e32dddb8b94819da89fca649ac182a6bd98f798cd5eac06303 |
| Notes | http://dx.doi.org/10.1016/j.jcis.2011.11.024 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 22200330 |
| PQID | 1010898591 |
| PQPubID | 23500 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_916521226 proquest_miscellaneous_1010898591 crossref_primary_10_1016_j_jcis_2011_11_024 pubmed_primary_22200330 pascalfrancis_primary_25697369 fao_agris_US201600077329 elsevier_sciencedirect_doi_10_1016_j_jcis_2011_11_024 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-02-15 |
| PublicationDateYYYYMMDD | 2012-02-15 |
| PublicationDate_xml | – month: 02 year: 2012 text: 2012-02-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: United States |
| PublicationTitle | Journal of colloid and interface science |
| PublicationTitleAlternate | J Colloid Interface Sci |
| PublicationYear | 2012 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Bava, Puliappadamba, Deepti, Nair, Karunagaran, Anto (b0100) 2005; 280 Laurent (b0145) 1987; 442 Maeda, Seymou, Miyamoto (b0140) 1992; 3 Herrlich, Leeman, Wainwright, Konig, Sherman, Ponta (b0155) 1998; 6 Gelperina (b0020) 2005; 172 Liang, Lin, Whittaker, Minchin, Monteiro, Toth (b0050) 2010; 4 Sharma (b0055) 1976; 25 Notarbartolo, Poma, Perri, Dusonchet, Cervello, D’Alessandro (b0110) 2005; 224 Wang, Pan, Cheng, Lin, Ho, Hsieh (b0115) 1997; 15 Moorthi, Manavalan, Kathiresan (b0005) 2011; 14 Babic, Horak, Jendelova, Glogarova, Herynek, Trchova (b0180) 2009; 20 Fraser, Laurent, Laurent (b0150) 1997; 242 Shyh-Dar, Huang (b0015) 2008; 5 Venkatpurwar, Shiras, Pokharkar (b0045) 2011; 409 Kawamori, Lubet, Steele, Kelloff, Kaskey, Rao (b0095) 1999; 59 Tuttle, Hertan, Katz (b0075) 2011; 11 Safavy, Raisch, Mantena, Sanford, Sham, Krishna (b0130) 2007; 50 Ishita, Kaushik, Uday, Ranajit (b0070) 2004; 87 Hall, Yang, Yang, Zhang, Turley, Samuel (b0160) 1995; 82 Arbiser, Klauber, Rohan (b0090) 1998; 4 Aggarwal, Kumar, Bharti (b0060) 2003; 23 Lee, Mok, Lee, Oh, Park (b0165) 2007; 119 Turkevich, Stevenson, Hillier (b0190) 1953; 57 Tomita, Kawakami, Uchihara, Okudaira, Masuda, Takasu (b0080) 2006; 118 Sharma, Euden, Platton, Cooke, Shafayat, Hewitt (b0120) 2004; 10 Liao, Hafner (b0195) 2005; 17 Xia, Low (b0175) 2010; 53 Giljohann, Seferos, Daniel, Massich, Patel, Mirkin (b0025) 2010; 49 Lee, Lee, Bae Ki, Park (b0030) 2010; 31 Zheng, Cai, Song, Chen, Bi, Li (b0170) 2009; 17 Lee, Powers, Baney (b0185) 2004; 58 Chen, Tsai, Huang, Chang, Cheng, Chou (b0035) 2007; 4 Huang, Newmark, Frenkel (b0125) 1997; 27 Gibson, Khanal, Zubarev (b0040) 2007; 129 Ramachandran, You (b0065) 1999; 54 Aggarwal, Shishodia (b0085) 2006; 71 Alexis, Pridgen, Molnar, Farokhzad (b0010) 2008; 5 Manju, Sreenivasan (b0135) 2011; 359 Chan, Fong, Soprano, Holmes, Heverling (b0105) 2003; 194 Lee (10.1016/j.jcis.2011.11.024_b0030) 2010; 31 Wang (10.1016/j.jcis.2011.11.024_b0115) 1997; 15 Gibson (10.1016/j.jcis.2011.11.024_b0040) 2007; 129 Lee (10.1016/j.jcis.2011.11.024_b0165) 2007; 119 Huang (10.1016/j.jcis.2011.11.024_b0125) 1997; 27 Herrlich (10.1016/j.jcis.2011.11.024_b0155) 1998; 6 Manju (10.1016/j.jcis.2011.11.024_b0135) 2011; 359 Moorthi (10.1016/j.jcis.2011.11.024_b0005) 2011; 14 Lee (10.1016/j.jcis.2011.11.024_b0185) 2004; 58 Liao (10.1016/j.jcis.2011.11.024_b0195) 2005; 17 Safavy (10.1016/j.jcis.2011.11.024_b0130) 2007; 50 Maeda (10.1016/j.jcis.2011.11.024_b0140) 1992; 3 Alexis (10.1016/j.jcis.2011.11.024_b0010) 2008; 5 Liang (10.1016/j.jcis.2011.11.024_b0050) 2010; 4 Aggarwal (10.1016/j.jcis.2011.11.024_b0060) 2003; 23 Ishita (10.1016/j.jcis.2011.11.024_b0070) 2004; 87 Giljohann (10.1016/j.jcis.2011.11.024_b0025) 2010; 49 Tuttle (10.1016/j.jcis.2011.11.024_b0075) 2011; 11 Shyh-Dar (10.1016/j.jcis.2011.11.024_b0015) 2008; 5 Sharma (10.1016/j.jcis.2011.11.024_b0120) 2004; 10 Venkatpurwar (10.1016/j.jcis.2011.11.024_b0045) 2011; 409 Gelperina (10.1016/j.jcis.2011.11.024_b0020) 2005; 172 Arbiser (10.1016/j.jcis.2011.11.024_b0090) 1998; 4 Hall (10.1016/j.jcis.2011.11.024_b0160) 1995; 82 Notarbartolo (10.1016/j.jcis.2011.11.024_b0110) 2005; 224 Zheng (10.1016/j.jcis.2011.11.024_b0170) 2009; 17 Ramachandran (10.1016/j.jcis.2011.11.024_b0065) 1999; 54 Tomita (10.1016/j.jcis.2011.11.024_b0080) 2006; 118 Bava (10.1016/j.jcis.2011.11.024_b0100) 2005; 280 Sharma (10.1016/j.jcis.2011.11.024_b0055) 1976; 25 Aggarwal (10.1016/j.jcis.2011.11.024_b0085) 2006; 71 Babic (10.1016/j.jcis.2011.11.024_b0180) 2009; 20 Chan (10.1016/j.jcis.2011.11.024_b0105) 2003; 194 Chen (10.1016/j.jcis.2011.11.024_b0035) 2007; 4 Xia (10.1016/j.jcis.2011.11.024_b0175) 2010; 53 Laurent (10.1016/j.jcis.2011.11.024_b0145) 1987; 442 Fraser (10.1016/j.jcis.2011.11.024_b0150) 1997; 242 Turkevich (10.1016/j.jcis.2011.11.024_b0190) 1953; 57 Kawamori (10.1016/j.jcis.2011.11.024_b0095) 1999; 59 |
| References_xml | – volume: 129 start-page: 11653 year: 2007 end-page: 11661 ident: b0040 publication-title: J. Am. Chem. Soc. contributor: fullname: Zubarev – volume: 5 start-page: 496 year: 2008 end-page: 504 ident: b0015 publication-title: Mol. Pharm. contributor: fullname: Huang – volume: 31 start-page: 6530 year: 2010 end-page: 6536 ident: b0030 publication-title: Biomaterials contributor: fullname: Park – volume: 59 start-page: 597 year: 1999 end-page: 601 ident: b0095 publication-title: Cancer Res. contributor: fullname: Rao – volume: 20 start-page: 283 year: 2009 end-page: 294 ident: b0180 publication-title: Bioconjugate Chem. contributor: fullname: Trchova – volume: 17 start-page: 4636 year: 2005 end-page: 4641 ident: b0195 publication-title: Chem. Mater. contributor: fullname: Hafner – volume: 5 start-page: 505 year: 2008 end-page: 515 ident: b0010 publication-title: Mol. Pharm. contributor: fullname: Farokhzad – volume: 53 start-page: 6811 year: 2010 end-page: 6824 ident: b0175 publication-title: J. Med. Chem. contributor: fullname: Low – volume: 359 start-page: 318 year: 2011 end-page: 325 ident: b0135 publication-title: J. Colloid Interface Sci. contributor: fullname: Sreenivasan – volume: 280 start-page: 6301 year: 2005 end-page: 6308 ident: b0100 publication-title: J. Biol. Chem. contributor: fullname: Anto – volume: 119 start-page: 245 year: 2007 end-page: 252 ident: b0165 publication-title: J. Control. Release contributor: fullname: Park – volume: 118 start-page: 765 year: 2006 end-page: 772 ident: b0080 publication-title: Int. J. Cancer contributor: fullname: Takasu – volume: 17 start-page: 294 year: 2009 end-page: 303 ident: b0170 publication-title: J. Drug Target contributor: fullname: Li – volume: 57 start-page: 670 year: 1953 end-page: 673 ident: b0190 publication-title: J. Phys. Chem. contributor: fullname: Hillier – volume: 23 start-page: 363 year: 2003 end-page: 398 ident: b0060 publication-title: Anticancer Res. contributor: fullname: Bharti – volume: 54 start-page: 269 year: 1999 end-page: 278 ident: b0065 publication-title: Breast Cancer Res. Treat. contributor: fullname: You – volume: 50 start-page: 6284 year: 2007 end-page: 6288 ident: b0130 publication-title: J. Med. Chem. contributor: fullname: Krishna – volume: 4 start-page: 713 year: 2007 end-page: 722 ident: b0035 publication-title: Mol. Pharmaceut. contributor: fullname: Chou – volume: 87 start-page: 44 year: 2004 end-page: 53 ident: b0070 publication-title: Curr. Sci. contributor: fullname: Ranajit – volume: 11 start-page: 474 year: 2011 end-page: 476 ident: b0075 publication-title: Cancer Biol. Ther. contributor: fullname: Katz – volume: 442 start-page: 7 year: 1987 end-page: 24 ident: b0145 publication-title: Acta Otolaryngol. Suppl. contributor: fullname: Laurent – volume: 71 start-page: 1397 year: 2006 end-page: 1421 ident: b0085 publication-title: Biochem. Pharmacol. contributor: fullname: Shishodia – volume: 15 start-page: 1867 year: 1997 end-page: 1876 ident: b0115 publication-title: J. Pharm. Biomed. Anal. contributor: fullname: Hsieh – volume: 172 start-page: 1487 year: 2005 end-page: 1490 ident: b0020 publication-title: Am. J. Respir. Crit. Care Med. contributor: fullname: Gelperina – volume: 242 start-page: 27 year: 1997 end-page: 33 ident: b0150 publication-title: J. Intern. Med. contributor: fullname: Laurent – volume: 3 start-page: 351 year: 1992 end-page: 362 ident: b0140 publication-title: Bioconjugate Chem. contributor: fullname: Miyamoto – volume: 4 start-page: 403 year: 2010 end-page: 413 ident: b0050 publication-title: ACS Nano contributor: fullname: Toth – volume: 49 start-page: 3280 year: 2010 end-page: 3295 ident: b0025 publication-title: Angew. Chem. Int. Ed. contributor: fullname: Mirkin – volume: 409 start-page: 314 year: 2011 end-page: 320 ident: b0045 publication-title: Int. J. Pharmaceut. contributor: fullname: Pokharkar – volume: 10 start-page: 6847 year: 2004 end-page: 6854 ident: b0120 publication-title: Clin. Cancer Res. contributor: fullname: Hewitt – volume: 58 start-page: 371 year: 2004 end-page: 377 ident: b0185 publication-title: Carbohydr. Polym. contributor: fullname: Baney – volume: 4 start-page: 376 year: 1998 end-page: 383 ident: b0090 publication-title: Mol. Med. contributor: fullname: Rohan – volume: 82 start-page: 19 year: 1995 end-page: 28 ident: b0160 publication-title: Cell contributor: fullname: Samuel – volume: 14 start-page: 67 year: 2011 end-page: 77 ident: b0005 publication-title: J. Pharm. Pharmaceut. Sci. contributor: fullname: Kathiresan – volume: 224 start-page: 53 year: 2005 end-page: 65 ident: b0110 publication-title: Cancer Lett. contributor: fullname: D’Alessandro – volume: 194 start-page: 63 year: 2003 end-page: 70 ident: b0105 publication-title: J. Cell Physiol. contributor: fullname: Heverling – volume: 27 start-page: 26 year: 1997 end-page: 34 ident: b0125 publication-title: J. Cell. Biochem. Suppl. contributor: fullname: Frenkel – volume: 6 start-page: 141 year: 1998 end-page: 147 ident: b0155 publication-title: Cell Adhes. Commun. contributor: fullname: Ponta – volume: 25 start-page: 1811 year: 1976 end-page: 1812 ident: b0055 publication-title: Biochem. Pharmacol. contributor: fullname: Sharma – volume: 359 start-page: 318 year: 2011 ident: 10.1016/j.jcis.2011.11.024_b0135 publication-title: J. Colloid Interface Sci. doi: 10.1016/j.jcis.2011.03.071 contributor: fullname: Manju – volume: 6 start-page: 141 year: 1998 ident: 10.1016/j.jcis.2011.11.024_b0155 publication-title: Cell Adhes. Commun. doi: 10.3109/15419069809004470 contributor: fullname: Herrlich – volume: 50 start-page: 6284 year: 2007 ident: 10.1016/j.jcis.2011.11.024_b0130 publication-title: J. Med. Chem. doi: 10.1021/jm700988f contributor: fullname: Safavy – volume: 409 start-page: 314 year: 2011 ident: 10.1016/j.jcis.2011.11.024_b0045 publication-title: Int. J. Pharmaceut. doi: 10.1016/j.ijpharm.2011.02.054 contributor: fullname: Venkatpurwar – volume: 5 start-page: 505 year: 2008 ident: 10.1016/j.jcis.2011.11.024_b0010 publication-title: Mol. Pharm. doi: 10.1021/mp800051m contributor: fullname: Alexis – volume: 20 start-page: 283 year: 2009 ident: 10.1016/j.jcis.2011.11.024_b0180 publication-title: Bioconjugate Chem. doi: 10.1021/bc800373x contributor: fullname: Babic – volume: 242 start-page: 27 year: 1997 ident: 10.1016/j.jcis.2011.11.024_b0150 publication-title: J. Intern. Med. doi: 10.1046/j.1365-2796.1997.00170.x contributor: fullname: Fraser – volume: 280 start-page: 6301 year: 2005 ident: 10.1016/j.jcis.2011.11.024_b0100 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M410647200 contributor: fullname: Bava – volume: 118 start-page: 765 year: 2006 ident: 10.1016/j.jcis.2011.11.024_b0080 publication-title: Int. J. Cancer doi: 10.1002/ijc.21389 contributor: fullname: Tomita – volume: 31 start-page: 6530 year: 2010 ident: 10.1016/j.jcis.2011.11.024_b0030 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.04.046 contributor: fullname: Lee – volume: 87 start-page: 44 year: 2004 ident: 10.1016/j.jcis.2011.11.024_b0070 publication-title: Curr. Sci. contributor: fullname: Ishita – volume: 3 start-page: 351 year: 1992 ident: 10.1016/j.jcis.2011.11.024_b0140 publication-title: Bioconjugate Chem. doi: 10.1021/bc00017a001 contributor: fullname: Maeda – volume: 4 start-page: 376 year: 1998 ident: 10.1016/j.jcis.2011.11.024_b0090 publication-title: Mol. Med. doi: 10.1007/BF03401744 contributor: fullname: Arbiser – volume: 17 start-page: 4636 year: 2005 ident: 10.1016/j.jcis.2011.11.024_b0195 publication-title: Chem. Mater. doi: 10.1021/cm050935k contributor: fullname: Liao – volume: 172 start-page: 1487 year: 2005 ident: 10.1016/j.jcis.2011.11.024_b0020 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.200504-613PP contributor: fullname: Gelperina – volume: 11 start-page: 474 year: 2011 ident: 10.1016/j.jcis.2011.11.024_b0075 publication-title: Cancer Biol. Ther. doi: 10.4161/cbt.11.5.14810 contributor: fullname: Tuttle – volume: 14 start-page: 67 year: 2011 ident: 10.1016/j.jcis.2011.11.024_b0005 publication-title: J. Pharm. Pharmaceut. Sci. doi: 10.18433/J30C7D contributor: fullname: Moorthi – volume: 58 start-page: 371 year: 2004 ident: 10.1016/j.jcis.2011.11.024_b0185 publication-title: Carbohydr. Polym. doi: 10.1016/j.carbpol.2004.06.033 contributor: fullname: Lee – volume: 54 start-page: 269 year: 1999 ident: 10.1016/j.jcis.2011.11.024_b0065 publication-title: Breast Cancer Res. Treat. doi: 10.1023/A:1006170224414 contributor: fullname: Ramachandran – volume: 4 start-page: 403 year: 2010 ident: 10.1016/j.jcis.2011.11.024_b0050 publication-title: ACS Nano doi: 10.1021/nn9011237 contributor: fullname: Liang – volume: 57 start-page: 670 year: 1953 ident: 10.1016/j.jcis.2011.11.024_b0190 publication-title: J. Phys. Chem. doi: 10.1021/j150508a015 contributor: fullname: Turkevich – volume: 5 start-page: 496 year: 2008 ident: 10.1016/j.jcis.2011.11.024_b0015 publication-title: Mol. Pharm. doi: 10.1021/mp800049w contributor: fullname: Shyh-Dar – volume: 71 start-page: 1397 year: 2006 ident: 10.1016/j.jcis.2011.11.024_b0085 publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2006.02.009 contributor: fullname: Aggarwal – volume: 119 start-page: 245 year: 2007 ident: 10.1016/j.jcis.2011.11.024_b0165 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2007.02.011 contributor: fullname: Lee – volume: 53 start-page: 6811 year: 2010 ident: 10.1016/j.jcis.2011.11.024_b0175 publication-title: J. Med. Chem. doi: 10.1021/jm100509v contributor: fullname: Xia – volume: 15 start-page: 1867 year: 1997 ident: 10.1016/j.jcis.2011.11.024_b0115 publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(96)02024-9 contributor: fullname: Wang – volume: 442 start-page: 7 year: 1987 ident: 10.1016/j.jcis.2011.11.024_b0145 publication-title: Acta Otolaryngol. Suppl. doi: 10.3109/00016488709102833 contributor: fullname: Laurent – volume: 194 start-page: 63 year: 2003 ident: 10.1016/j.jcis.2011.11.024_b0105 publication-title: J. Cell Physiol. doi: 10.1002/jcp.10186 contributor: fullname: Chan – volume: 82 start-page: 19 year: 1995 ident: 10.1016/j.jcis.2011.11.024_b0160 publication-title: Cell doi: 10.1016/0092-8674(95)90048-9 contributor: fullname: Hall – volume: 59 start-page: 597 year: 1999 ident: 10.1016/j.jcis.2011.11.024_b0095 publication-title: Cancer Res. contributor: fullname: Kawamori – volume: 129 start-page: 11653 year: 2007 ident: 10.1016/j.jcis.2011.11.024_b0040 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja075181k contributor: fullname: Gibson – volume: 17 start-page: 294 year: 2009 ident: 10.1016/j.jcis.2011.11.024_b0170 publication-title: J. Drug Target doi: 10.1080/10611860902737920 contributor: fullname: Zheng – volume: 10 start-page: 6847 year: 2004 ident: 10.1016/j.jcis.2011.11.024_b0120 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-0744 contributor: fullname: Sharma – volume: 4 start-page: 713 year: 2007 ident: 10.1016/j.jcis.2011.11.024_b0035 publication-title: Mol. Pharmaceut. doi: 10.1021/mp060132k contributor: fullname: Chen – volume: 25 start-page: 1811 year: 1976 ident: 10.1016/j.jcis.2011.11.024_b0055 publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(76)90421-4 contributor: fullname: Sharma – volume: 49 start-page: 3280 year: 2010 ident: 10.1016/j.jcis.2011.11.024_b0025 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.200904359 contributor: fullname: Giljohann – volume: 23 start-page: 363 year: 2003 ident: 10.1016/j.jcis.2011.11.024_b0060 publication-title: Anticancer Res. contributor: fullname: Aggarwal – volume: 224 start-page: 53 year: 2005 ident: 10.1016/j.jcis.2011.11.024_b0110 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.10.051 contributor: fullname: Notarbartolo – volume: 27 start-page: 26 year: 1997 ident: 10.1016/j.jcis.2011.11.024_b0125 publication-title: J. Cell. Biochem. Suppl. doi: 10.1002/(SICI)1097-4644(1997)27+<26::AID-JCB7>3.0.CO;2-3 contributor: fullname: Huang |
| SSID | ssj0011559 |
| Score | 2.4889343 |
| Snippet | [Display omitted]
► Curcumin conjugated AuNPs were synthesized using hyaluronic acid-curcumin conjugates. ► HA–Cur@AuNPs were further HA–Cur@AuNPs modified... Curcumin (Cur) shows low anticancer activity in vivo due to its reduced systemic bioavailability stemmed from its poor aqueous solubility and instability.... |
| SourceID | proquest crossref pubmed pascalfrancis fao elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 144 |
| SubjectTerms | Antineoplastic Agents - pharmacology bioavailability Biocompatibility Biocompatible Materials Blood Blood Coagulation - drug effects Cancer Cell Proliferation - drug effects Chemistry Colloidal state and disperse state Confocal confocal microscopy curcumin Curcumin - pharmacology cytotoxicity Dose-Response Relationship, Drug Drug Delivery Systems Drug Screening Assays, Antitumor Exact sciences and technology Flow cytometry folic acid Folic acid conjugated polyethylene glycol General and physical chemistry Gold Gold - chemistry Gold nanoparticle HeLa Cells Hemocompatibility Humans Hyaluronic acid Hyaluronic Acid - chemistry Magnetics Membranes, Artificial Metal Nanoparticles nanocarriers nanogold Nanoparticles Nanostructure neoplasm cells Physical and chemical studies. Granulometry. Electrokinetic phenomena Solubility Structure-Activity Relationship Surface Properties Tumor Cells, Cultured Water - chemistry Water soluble curcumin |
| Title | Gold nanoparticles generated and stabilized by water soluble curcumin–polymer conjugate: Blood compatibility evaluation and targeted drug delivery onto cancer cells |
| URI | https://dx.doi.org/10.1016/j.jcis.2011.11.024 https://www.ncbi.nlm.nih.gov/pubmed/22200330 https://search.proquest.com/docview/1010898591 https://search.proquest.com/docview/916521226 |
| Volume | 368 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtNAEF6l7QE4ICjQhp9qkbhFjupdO7a5lRIoIHFpK_VmrXfXVaLUruIYFE68A-_Ag_EkzHj8k1AFARKXKLI23nXm292Z8bffMPbCBx8_cXXopCo0jifc1FGR9B0_kUmURK61lfD8yWnw8SJ8PfbGvV5TlrS79l8tDdfA1nhy9i-s3d4ULsB3sDl8gtXh84_s_jafmUGmMgiGa84bVklG6WRbqbJi8gAJsV_I9fysUCURh4RHqHQ51-XVJGsoEPI6ny2voAFEzdMSM26YQXiFZHdiry-IXLtcUQ0nTmZFMIcuzLy8HBg7Q_rHcoBiCcgz03hLO5sVG3xjRGc-MbU0FFbSViiFS-tQl0SHMVXZ22GbJ0IW0eSTKiit-2G4mtRAdohw6FgnZdqa0zZrZFCikwTE5x1aWrDBRUQ-qVxd0eUovAFdWp9dEpust3qXtG5v7CKU0JgOp3pSkMorCr0Kr9szWyYjvux2cUwuFj2udA12BKx5sOTuHL0bX7xvX2nh-1_iG9FD1Ce4iGz4a0-bvKStVOVI31UFzOCUSq9sjo0qH-nsHrtbG5AfEfDus57Ndtmt46am4C67syJ_-YB9R6zyNazyFqscbM87rPJkySus8hqrvMHqj6_fapTyFqUveYVRvoZR3mG0unmDUY4Y5Q1GOWKUE0Z5hdGH7PzN-Oz4xKnrhjja88TCCUIbHCaw1ASuAO_LSmGMScIEhYkio8Io1WrkRUpDbK1GiYnCNIhCbXxwQlCCTj5i21me2X3GU9gQPWt0iCJLQmOaNIWgSabQWOrI77NBY6f4muRh4oY3OY3RqjFaFeLsGKzaZ35jyrieMuS4xoC83_5uH-weq0vY9-PzU4GqkKjDJUXUZwdrYGhHAaFMFMgRNHjeoCMGY-P_pjKblwV2dhhGqF_ZZ3xDGwge8XC_GPXZHiGr60Agr1UePv7Hh3rCbncz_ynbXsxL-4xtFaY8qKfOT8tHApA |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gold+nanoparticles+generated+and+stabilized+by+water+soluble+curcumin%E2%80%93polymer+conjugate%3A+Blood+compatibility+evaluation+and+targeted+drug+delivery+onto+cancer+cells&rft.jtitle=Journal+of+colloid+and+interface+science&rft.au=Manju%2C+S.&rft.au=Sreenivasan%2C+K.&rft.date=2012-02-15&rft.pub=Elsevier+Inc&rft.issn=0021-9797&rft.eissn=1095-7103&rft.volume=368&rft.issue=1&rft.spage=144&rft.epage=151&rft_id=info:doi/10.1016%2Fj.jcis.2011.11.024&rft.externalDocID=S0021979711014007 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9797&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9797&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9797&client=summon |