Exposure to pesticides and mental disorders in a rural population of Southern Brazil

• Published in: Neurotoxicology (Park Forest South) Vol. 56; pp. 7 - 16
• Main Authors: Campos, ÿlida, dos Santos Pinto da Silva, Valéria, Sarpa Campos de Mello, Márcia, Barros Otero, Ubirani
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-09-2016
• Subjects: Adolescent; Adult; Age Distribution; Aged; Brazil - epidemiology; Cross-Sectional Studies; Depression; Female; Humans; Male; Mental disorder; Mental Disorders - chemically induced; Mental Disorders - epidemiology; Middle Aged; Occupational Exposure - adverse effects; Pesticide; Pesticides - adverse effects; Rural Population; Surveys and Questionnaires; Tobacco farming; Young Adult; Mental disorder; Depression; Pesticide; Tobacco farming; Rural population
• ISSN: 0161-813X; 1872-9711
• DOI: 10.1016/j.neuro.2016.06.002

Exposure to pesticides has been associated with mental disorders, especially in occupationally exposed populations, such as farmers. This effect has been attributed to the neurotoxic and endocrine-disrupting activity of pesticides, as suggested by experimental studies.
To determine the prevalence of common mental disorders and self-reported depression, and analyze their association with the exposure to pesticides in a rural population resident in the municipality of Dom Feliciano, Rio Grande do Sul, where tobacco farming is the main economic activity.
A cross-sectional study evaluating the prevalence of common mental disorders and self-reported depression in a sample of 869 adult individuals resident in Dom Feliciano, between October 2011 and March 2012 was performed. The evaluation of common mental disorders was performed using the Self-Reporting Questionnaire (SRQ-20), setting a cutoff point of 8 for both genders. A standardized questionnaire was used to obtain information on self-reported depression upon prior diagnosis by a health professional, and self-reported exposure to pesticide. In order to evaluate the association between exposure to pesticides and mental disorders, a non-conditional multivariate logistic regression analysis was performed.
The prevalence of common mental disorders and self-reported depression in the sample population were 23% and 21%, respectively. Among individuals who reported depression, an increase of 73% was observed in the odds of pesticide exposure at an age equal to or less than 15 years. There was a positive association between self-reported pesticide poisoning and common mental disorders (OR=2.63; 95% CI, 1.62-4.25) as well as self-reported depression (OR=2.62; 95% CI, 1.63⿿4.21). Individuals who reported depression had a greater odds of exposure to pyrethroids (OR=1.80; 95% CI, 1.01⿿3.21) and aliphatic alcohol (OR=1.99; 95% CI, 1.04⿿3.83). An SRQ⿿20⿥8 was associated with an approximately seven times higher odds of exposure to aliphatic alcohol (95% CI, 1.73⿿27.53). Self-reported depression positively correlated with a greater period of exposure to dinitroaniline (OR=2.20; 95% CI, 1.03⿿4.70) and sulphonylurea (OR=4.95; 95% CI, 1.06⿿23.04).
The results suggest that exposure to pesticides could be related mental disorders. However, other common risk factors in tobacco farming, the main local economic activity, cannot be excluded.