Myeloperoxydase Expression in The Pathogenesis of Nasal Polyps
Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to...
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| Published in: | Indian journal of otolaryngology, and head, and neck surgery Vol. 63; no. 3; pp. 260 - 263 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer-Verlag
01-07-2011
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| Abstract | Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to the inflammatory area and form their bactericidal effects by producing free oxygen radicals. The objective of our study is to investigate the expression of myeloperoxydase enzyme, which is usually an indicator of leukocyte infiltration and is responsible in the formation of free oxygen radicals in polyp tissues and to determine its role in the pathogenesis of nasal polyps. |
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| AbstractList | Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to the inflammatory area and form their bactericidal effects by producing free oxygen radicals. The objective of our study is to investigate the expression of myeloperoxydase enzyme, which is usually an indicator of leukocyte infiltration and is responsible in the formation of free oxygen radicals in polyp tissues and to determine its role in the pathogenesis of nasal polyps. |
| Author | Sarisoy, Burcin A. Paksoy, Mustafa Sanli, Arif Oktay, Alev Z. Eken, Mehmet |
| Author_xml | – sequence: 1 givenname: Burcin A. surname: Sarisoy fullname: Sarisoy, Burcin A. organization: Department of Second ENT, Kartal Training and Research Hospital, Giresun State Hospital – sequence: 2 givenname: Mehmet surname: Eken fullname: Eken, Mehmet email: memedeken@yahoo.com organization: Department of Second ENT, Kartal Training and Research Hospital – sequence: 3 givenname: Alev Z. surname: Oktay fullname: Oktay, Alev Z. organization: Department of Second ENT, Kartal Training and Research Hospital, Giresun State Hospital – sequence: 4 givenname: Mustafa surname: Paksoy fullname: Paksoy, Mustafa organization: Department of Second ENT, Kartal Training and Research Hospital – sequence: 5 givenname: Arif surname: Sanli fullname: Sanli, Arif organization: Department of Second ENT, Kartal Training and Research Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22754806$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.anl.2008.09.007 10.1016/j.otohns.2005.09.032 10.1097/00130832-200302000-00001 10.1016/S0385-8146(99)00038-3 10.1021/bi00449a032 10.1111/j.1365-2222.1997.tb01195.x 10.1067/mhn.2001.115086 10.1074/jbc.270.7.2906 10.1111/j.1398-9995.2008.01829.x 10.1007/s00011-003-1232-2 10.2500/105065800781329573 10.1111/j.1398-9995.2006.01225.x 10.1021/bi00427a025 |
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| Keywords | Free oxygen radicals Myeloperoxidase Inflammation Nasal polyps |
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| References_xml | – volume: 135 start-page: 653 year: 1996 end-page: 655 ident: CR6 article-title: A study of free radicals and scaveging enzyme in tonsillitis publication-title: Boll Chim Farm contributor: fullname: Pandey – volume: 14 start-page: 427 year: 2009 end-page: 430 ident: CR2 article-title: Does play a role in etiology of nasal polyposis? publication-title: Auris Nasus Larynx doi: 10.1016/j.anl.2008.09.007 contributor: fullname: Gorur – ident: CR4 – volume: 134 start-page: 37 year: 2006 end-page: 40 ident: CR16 article-title: Malondialdehyde level and adenosine deaminase activity in nasal polyps publication-title: Otolaryngol Head Neck Surg doi: 10.1016/j.otohns.2005.09.032 contributor: fullname: Kilic – volume: 3 start-page: 1 year: 2003 end-page: 6 ident: CR3 article-title: Nasal polyposis: an update: editorial review publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/00130832-200302000-00001 contributor: fullname: Pawankar – volume: 27 start-page: 59 year: 2000 end-page: 64 ident: CR12 article-title: Inflammatory cells in nasal mucosa and nasal polyps publication-title: Auris Nasus Larynx doi: 10.1016/S0385-8146(99)00038-3 contributor: fullname: Nakamura – volume: 28 start-page: 172 year: 1989 end-page: 178 ident: CR14 article-title: General mechanism for the bacterial toxicity of hypochlorous acid: abolition of ATP production publication-title: Biochemistry doi: 10.1021/bi00449a032 contributor: fullname: Hurst – volume: 27 start-page: 672 year: 1997 end-page: 675 ident: CR15 article-title: Myeloperoxidase and interleukin-8 (IL-8) levels in chronic sinusitis publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.1997.tb01195.x contributor: fullname: Bousquet – ident: CR5 – volume: 124 start-page: 570 year: 2001 end-page: 572 ident: CR7 article-title: Free radical damage in nasal polyp tissue publication-title: Otolaryngol Head Neck Surg doi: 10.1067/mhn.2001.115086 contributor: fullname: Uygur – volume: 270 start-page: 2906 year: 1995 end-page: 2913 ident: CR13 article-title: Oxidation of bromide by the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase: formation of bromamines publication-title: J Biol Chem doi: 10.1074/jbc.270.7.2906 contributor: fullname: King – volume: 64 start-page: 104 year: 2009 end-page: 111 ident: CR9 article-title: Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps publication-title: Allergy doi: 10.1111/j.1398-9995.2008.01829.x contributor: fullname: Liu – volume: 53 start-page: 111 year: 2004 end-page: 117 ident: CR11 article-title: Chronic rhinosinusitis-need for further classification? 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| Title | Myeloperoxydase Expression in The Pathogenesis of Nasal Polyps |
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