Effect of colchicine on polycystic ovary syndrome: an experimental study

• Published in: Archives of gynecology and obstetrics Vol. 293; no. 3; pp. 675 - 680
• Main Authors: Gozukara, Ilay Ozturk, Pınar, Neslihan, Ozcan, Oğuzhan, Ozgur, Tumay, Dokuyucu, Recep, Kurt, Raziye Keskin, Kucur, Suna Kabil, Aksoy, Ayşe Nur
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2016; Springer Nature B.V
• Subjects: Androstenedione - blood; Animals; Antidiabetics; C-Reactive Protein - metabolism; Colchicine - administration & dosage; Colchicine - therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Endocrinology; Estradiol - blood; Female; Gynecologic Endocrinology and Reproductive Medicine; Gynecology; Human Genetics; Humans; Medicine; Medicine & Public Health; Metformin - administration & dosage; Metformin - therapeutic use; Obstetrics/Perinatology/Midwifery; Ovarian Follicle - drug effects; Ovary - drug effects; Ovary - pathology; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - chemically induced; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - pathology; Random Allocation; Rats; Rats, Wistar; Rodents; Testosterone - blood; Tubulin Modulators - administration & dosage; Tubulin Modulators - therapeutic use; PCOS; Colchicine; Metformin
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-015-3933-5

Purpose
To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS).
Methods
Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E
1
), estradiol (E
2
), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated. Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment.
Conclusion
Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.