Efficacy of 100 mg of double-bolus alteplase in achieving complete perfusion in the treatment of acute myocardial infarction

Objectives. The purpose of this study was to assess the efficacy of 150 mg of aspirin plus 100 mg of alteplase, administered as two intravenous bolus injections of 50 mg each given 30 min apart, and followed by intravenous heparin, on infarct-related coronary artery patency (Thrombolysis in Myocardi...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 23; no. 1; pp. 6 - 10
Main Authors:	Purvis, John A., McNeill, Albert J., Siddiqui, Rizwan A., Roberts, Michael J.D., McClements, Brian M., McEneaney, David, Campbell, Norman P.S., Khan, Mazhar M., Webb, Sam W., Wilson, Carol M., Adgey, A.A.Jennifer
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-01-1994 Elsevier Science
Subjects:	Adult Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Coronary Angiography Female Humans Injections, Intravenous Male Medical sciences Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology Pharmacology. Drug treatments Pilot Projects Prospective Studies Thrombolytic Therapy - adverse effects Thrombolytic Therapy - methods Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use Vascular Patency - drug effects Human Drug combination Intravenous administration Radiodiagnosis Serine endopeptidases Infarct Enzyme Treatment efficiency Coronary artery Cardiovascular disease Anticoagulant Coronary arteriography Coronary heart disease t-Plasminogen activator Fractionated dose Chemotherapy Treatment Myocardium Hydrolases Heparin Salicylates Proteinases Fibrinolytic
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