Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys

Nicotine, the main psychoactive component of tobacco, and (-)-Δ(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and marijuana dependence as reinforcers of drug-seeking and drug-taking behavior. Drugs that act as inverse agonists of cannabinoid...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 9; pp. 2283 - 2293
Main Authors:	Schindler, Charles W, Redhi, Godfrey H, Vemuri, Kiran, Makriyannis, Alexandros, Le Foll, Bernard, Bergman, Jack, Goldberg, Steven R, Justinova, Zuzana
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-08-2016
Subjects:	Addictions Addictive behaviors Ambulatory care Animals Behavior Brain research Cocaine Conditioning, Operant - drug effects Cues Dronabinol - administration & dosage Drug abuse Drug-Seeking Behavior - drug effects Male Marijuana Marijuana Abuse - prevention & control Mental health Monkeys & apes Nicotine Nicotine - administration & dosage Original Pharmacology Piperidines - administration & dosage Pyrazoles - administration & dosage Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Recurrence Reinforcement (Psychology) Rimonabant Saimiri Self Administration Smoking Tetrahydrocannabinol THC Tobacco Tobacco Use Disorder - prevention & control Canada United States > US Baltimore Maryland
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