A review and expert opinion of the use of certolizumab for Crohn's disease

Crohn's disease (CD) is a chronic, idiopathic, inflammatory bowel disease with no known cure. In those patients with moderate to severe disease, the result is often a clinically debilitating condition. In the last decade, one of the most significant developments in therapy has been a class of b...

Full description

Saved in:

Bibliographic Details
Published in:	Expert opinion on biological therapy Vol. 12; no. 3; p. 363
Main Authors:	Evans, Ashley T, Lee, Scott D
Format:	Journal Article
Language:	English
Published:	England 01-03-2012
Subjects:	Antibodies, Monoclonal, Humanized - therapeutic use Certolizumab Pegol Crohn Disease - drug therapy Expert Testimony Humans Immunoglobulin Fab Fragments - therapeutic use Polyethylene Glycols - therapeutic use
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Crohn's disease (CD) is a chronic, idiopathic, inflammatory bowel disease with no known cure. In those patients with moderate to severe disease, the result is often a clinically debilitating condition. In the last decade, one of the most significant developments in therapy has been a class of biological agents that neutralize TNFa. Certolizumab pegol (CZP) is the most recently FDA approved anti-TNF agent for the induction and maintenance of moderate to severely active Crohn's disease. The currently available evidence regarding the use of CZP in CD, the expected efficacy and possible adverse events associated with this population. CZP is a TNFa inhibitor that is a safe and effective agent for treatment of CD. It has several unique features which make it useful in patients with moderate to severe disease.
ISSN:	1744-7682
DOI:	10.1517/14712598.2012.658770