n-3 fatty acid deficiency increases brain protein synthesis in the free-moving adult rat

The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 63; no. 5; p. 1995
Main Authors:	Giaume, M, Gay, N, Baubet, V, Gharib, A, Durand, G, Bobillier, P, Sarda, N
Format:	Journal Article
Language:	English
Published:	England 01-11-1994
Subjects:	Animals Autoradiography Brain - metabolism Brain - physiology Deficiency Diseases - metabolism Deficiency Diseases - physiopathology Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - physiology Female Methionine - metabolism Movement - physiology Proteins - metabolism Rats Rats, Wistar Sulfur Radioisotopes
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Summary:	The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control animals. Biochemical analysis confirmed the increase in overall rate of protein synthesis in brain as a whole.
ISSN:	0022-3042
DOI:	10.1046/j.1471-4159.1994.63051995.x