Use of An Isolated Intestinal Circuit to Evaluate the Effect of Ischemia and Reperfusion on Mucosal Permeability of the Equine Jejunum
Objective— To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum. Study Design— In vitro study of intestinal mucosal permeability. Animals— Twelve healthy adult horses. Methods— A control segment of jejunum was placed...
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| Published in: | Veterinary surgery Vol. 32; no. 1; pp. 52 - 61 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford, UK
Blackwell Science Inc
01-01-2003
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| Abstract | Objective— To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum.
Study Design— In vitro study of intestinal mucosal permeability.
Animals— Twelve healthy adult horses.
Methods— A control segment of jejunum was placed in an isolated perfusion circuit for 240 minutes and mucosal permeability was measured. After detecting no deleterious effects of the isolated system on the control intestine, low flow ischemia was created in experimental segments for 20, 40, 60 and 90 minutes followed by 60 minutes of reperfusion and mucosal permeability was evaluated. At the completion of the studies, histologic evaluation was used to determine mucosal grades, surface area, and volume.
Results— Control tissue was maintained in the isolated circuit for 240 minutes without effect on mucosal grade, surface area, or volume relative to intact tissue. After ischemia‐reperfusion, mucosal grade increased, and volume and surface area decreased progressively with longer periods of ischemia. Mucosal clearance of albumin remained constant during 240 minutes of perfusion in control tissue and was elevated after ischemia‐reperfusion.
Conclusions— No deleterious changes were noted in jejunum perfused with this isolated circuit, whereas alterations in mucosal permeability were present after ischemia‐reperfusion.
Clinical Relevance— The isolated perfusion circuit successfully maintained an isolated segment of jejunum within physiologic limits, and can be used to evaluate the effects of injury and the efficacy of pharmaceuticals to attenuate these changes. |
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| AbstractList | Objective—
To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum.
Study Design—
In vitro study of intestinal mucosal permeability.
Animals—
Twelve healthy adult horses.
Methods—
A control segment of jejunum was placed in an isolated perfusion circuit for 240 minutes and mucosal permeability was measured. After detecting no deleterious effects of the isolated system on the control intestine, low flow ischemia was created in experimental segments for 20, 40, 60 and 90 minutes followed by 60 minutes of reperfusion and mucosal permeability was evaluated. At the completion of the studies, histologic evaluation was used to determine mucosal grades, surface area, and volume.
Results—
Control tissue was maintained in the isolated circuit for 240 minutes without effect on mucosal grade, surface area, or volume relative to intact tissue. After ischemia‐reperfusion, mucosal grade increased, and volume and surface area decreased progressively with longer periods of ischemia. Mucosal clearance of albumin remained constant during 240 minutes of perfusion in control tissue and was elevated after ischemia‐reperfusion.
Conclusions—
No deleterious changes were noted in jejunum perfused with this isolated circuit, whereas alterations in mucosal permeability were present after ischemia‐reperfusion.
Clinical Relevance—
The isolated perfusion circuit successfully maintained an isolated segment of jejunum within physiologic limits, and can be used to evaluate the effects of injury and the efficacy of pharmaceuticals to attenuate these changes. To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia-reperfusion on mucosal permeability of the jejunum. In vitro study of intestinal mucosal permeability. Twelve healthy adult horses. A control segment of jejunum was placed in an isolated perfusion circuit for 240 minutes and mucosal permeability was measured. After detecting no deleterious effects of the isolated system on the control intestine, low flow ischemia was created in experimental segments for 20, 40, 60 and 90 minutes followed by 60 minutes of reperfusion and mucosal permeability was evaluated. At the completion of the studies, histologic evaluation was used to determine mucosal grades, surface area, and volume. Control tissue was maintained in the isolated circuit for 240 minutes without effect on mucosal grade, surface area, or volume relative to intact tissue. After ischemia-reperfusion, mucosal grade increased, and volume and surface area decreased progressively with longer periods of ischemia. Mucosal clearance of albumin remained constant during 240 minutes of perfusion in control tissue and was elevated after ischemia-reperfusion. No deleterious changes were noted in jejunum perfused with this isolated circuit, whereas alterations in mucosal permeability were present after ischemia-reperfusion. The isolated perfusion circuit successfully maintained an isolated segment of jejunum within physiologic limits, and can be used to evaluate the effects of injury and the efficacy of pharmaceuticals to attenuate these changes. Objective— To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum. Study Design— In vitro study of intestinal mucosal permeability. Animals— Twelve healthy adult horses. Methods— A control segment of jejunum was placed in an isolated perfusion circuit for 240 minutes and mucosal permeability was measured. After detecting no deleterious effects of the isolated system on the control intestine, low flow ischemia was created in experimental segments for 20, 40, 60 and 90 minutes followed by 60 minutes of reperfusion and mucosal permeability was evaluated. At the completion of the studies, histologic evaluation was used to determine mucosal grades, surface area, and volume. Results— Control tissue was maintained in the isolated circuit for 240 minutes without effect on mucosal grade, surface area, or volume relative to intact tissue. After ischemia‐reperfusion, mucosal grade increased, and volume and surface area decreased progressively with longer periods of ischemia. Mucosal clearance of albumin remained constant during 240 minutes of perfusion in control tissue and was elevated after ischemia‐reperfusion. Conclusions— No deleterious changes were noted in jejunum perfused with this isolated circuit, whereas alterations in mucosal permeability were present after ischemia‐reperfusion. Clinical Relevance— The isolated perfusion circuit successfully maintained an isolated segment of jejunum within physiologic limits, and can be used to evaluate the effects of injury and the efficacy of pharmaceuticals to attenuate these changes. OBJECTIVESTo evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia-reperfusion on mucosal permeability of the jejunum.STUDY DESIGNIn vitro study of intestinal mucosal permeability.ANIMALSTwelve healthy adult horses.METHODSA control segment of jejunum was placed in an isolated perfusion circuit for 240 minutes and mucosal permeability was measured. After detecting no deleterious effects of the isolated system on the control intestine, low flow ischemia was created in experimental segments for 20, 40, 60 and 90 minutes followed by 60 minutes of reperfusion and mucosal permeability was evaluated. At the completion of the studies, histologic evaluation was used to determine mucosal grades, surface area, and volume.RESULTSControl tissue was maintained in the isolated circuit for 240 minutes without effect on mucosal grade, surface area, or volume relative to intact tissue. After ischemia-reperfusion, mucosal grade increased, and volume and surface area decreased progressively with longer periods of ischemia. Mucosal clearance of albumin remained constant during 240 minutes of perfusion in control tissue and was elevated after ischemia-reperfusion.CONCLUSIONSNo deleterious changes were noted in jejunum perfused with this isolated circuit, whereas alterations in mucosal permeability were present after ischemia-reperfusion.CLINICAL RELEVANCEThe isolated perfusion circuit successfully maintained an isolated segment of jejunum within physiologic limits, and can be used to evaluate the effects of injury and the efficacy of pharmaceuticals to attenuate these changes. |
| Author | Vatistas, Nicholas J. van Hoogmoed, Linda Nieto, Jorge E. Gardner, Ian Snyder, Jack R. |
| Author_xml | – sequence: 1 givenname: Nicholas J. surname: Vatistas fullname: Vatistas, Nicholas J. organization: Deceased – sequence: 2 givenname: Jorge E. surname: Nieto fullname: Nieto, Jorge E. organization: From the Comparative Gastroenterology Laboratory, Department of Surgical and Radiological Sciences and Department of Medicine and Epidemiology School of Veterinary Medicine, University of California, Davis, CA – sequence: 3 givenname: Linda surname: van Hoogmoed fullname: van Hoogmoed, Linda organization: From the Comparative Gastroenterology Laboratory, Department of Surgical and Radiological Sciences and Department of Medicine and Epidemiology School of Veterinary Medicine, University of California, Davis, CA – sequence: 4 givenname: Ian surname: Gardner fullname: Gardner, Ian organization: From the Comparative Gastroenterology Laboratory, Department of Surgical and Radiological Sciences and Department of Medicine and Epidemiology School of Veterinary Medicine, University of California, Davis, CA – sequence: 5 givenname: Jack R. surname: Snyder fullname: Snyder, Jack R. organization: From the Comparative Gastroenterology Laboratory, Department of Surgical and Radiological Sciences and Department of Medicine and Epidemiology School of Veterinary Medicine, University of California, Davis, CA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12520490$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1038_sj_bjp_0706431 crossref_primary_10_1186_s12917_019_2145_9 crossref_primary_10_1016_j_nut_2009_04_010 crossref_primary_10_3748_wjg_14_463 crossref_primary_10_1016_j_ajt_2023_10_026 crossref_primary_10_1016_j_nut_2010_05_014 crossref_primary_10_2746_042516408X278193 |
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| Copyright | Copyright 2003 by The American College of Veterinary Surgeons |
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| Snippet | Objective— To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum.
Study... To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia-reperfusion on mucosal permeability of the jejunum. In vitro study of... Objective— To evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia‐reperfusion on mucosal permeability of the jejunum. Study... OBJECTIVESTo evaluate the efficacy of an isolated perfusion circuit and the effect of ischemia-reperfusion on mucosal permeability of the jejunum.STUDY... |
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| SubjectTerms | Albumins - pharmacokinetics Animals Blood Flow Velocity Extracorporeal Circulation - veterinary Horse Diseases - physiopathology Horses - physiology Intestinal Mucosa - blood supply Ischemia - physiopathology Ischemia - veterinary Jejunal Diseases - physiopathology Jejunal Diseases - veterinary Jejunum - blood supply Muscle Contraction Reperfusion - veterinary |
| Title | Use of An Isolated Intestinal Circuit to Evaluate the Effect of Ischemia and Reperfusion on Mucosal Permeability of the Equine Jejunum |
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