Urbanization and kidney dysfunction in Brazilian indigenous people: a burden for the youth

• Published in: Revista da Associacao Medica Brasileira (1992) Vol. 69; no. 2; pp. 240 - 245
• Main Authors: Gomes, Orlando Vieira, Guimarães, Manoel Pereira, Nicacio, Jandir Mendonça, Morena, Leela, Silva, Antônio Marconi Leandro da, Morais Junior, Jeová Cordeiro de, Souza, Carlos Dornels Freire de, Barral Netto, Manoel, Lima, João Augusto Costa, Armstrong, Anderson da Costa
• Format: Magazine Article
• Language: English
• Published: Brazil Associação Médica Brasileira 01-01-2023
• Subjects: Adolescent; Adult; Aged; Brazil - epidemiology; Creatinine; Cross-Sectional Studies; Glomerular Filtration Rate; Humans; Indigenous Peoples; Kidney; Middle Aged; Original; Renal Insufficiency, Chronic - epidemiology; Urbanization; Brazil
• ISSN: 0104-4230; 1806-9282
• DOI: 10.1590/1806-9282.20220934

The aim of this study was to investigate whether the degree of urbanization influences the prevalence of chronic kidney disease in Brazilian indigenous people.
This is a cross-sectional study conducted between 2016 and 2017 in northeastern Brazil and includes individuals aged between 30 and 70 years from two specific indigenous groups who volunteered to participate in the study: the Fulni-ô people (lowest degree of urbanization) and the Truká group (greater degree of urbanization). Cultural and geographical parameters were used to characterize and measure the magnitude of urbanization. We excluded individuals with known cardiovascular disease or renal failure who required hemodialysis. Chronic kidney disease was defined as a single measurement of an estimated glomerular filtration rate <60 mL/min/1.73 m2 using the Chronic Kidney Disease Epidemiology Collaboration creatinine equation.
A total of 184 indigenous people from the Fulni-ô group and 96 from the Truká group with a median age of 46 years (interquartile range: 15.2) were included. We found a chronic kidney disease rate of 4.3% in the total indigenous population, generally affecting an older population: 41.7% over 60 years old (p<0.001). The Truká people had a chronic kidney disease prevalence of 6.2%, with no differences in kidney dysfunction across age groups. The Fulni-ô participants had a chronic kidney disease prevalence of 3.3%, with a higher proportion of kidney dysfunction in older participants (of the six Fulni-ô indigenous people with chronic kidney disease, five were older).
Our results suggest that a higher degree of urbanization seems to negatively influence the prevalence of chronic kidney disease in Brazilian indigenous people.