Anaemia and congestive heart failure early post-renal transplantation

• Published in: Nephrology, dialysis, transplantation Vol. 23; no. 5; pp. 1728 - 1734
• Main Authors: Borrows, Richard, Loucaidou, Marina, Chusney, Gary, Borrows, Sarah, Tromp, Jen Van, Cairns, Tom, Griffith, Megan, Hakim, Nadey, McLean, Adam, Palmer, Andrew, Papalois, Vassilios, Taube, David
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-05-2008; Oxford Publishing Limited (England)
• Subjects: Adult; anaemia; Anemia - blood; Anemia - etiology; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; congestive heart failure; Emergency and intensive care: renal failure. Dialysis management; Erythropoietin - administration & dosage; Female; Heart Failure - etiology; Hemoglobins - metabolism; Humans; Hypoalbuminemia - etiology; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Intensive care medicine; kidney transplant; Kidney Transplantation - adverse effects; Kidney Transplantation - physiology; Male; Medical sciences; Middle Aged; Mycophenolic Acid - administration & dosage; Mycophenolic Acid - adverse effects; Mycophenolic Acid - analogs & derivatives; Prospective Studies; Recombinant Proteins; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tacrolimus - administration & dosage; Tacrolimus - adverse effects; Time Factors; kidney transplant; congestive heart failure; anaemia; Kidney disease; Heart failure; Extrarenal dialysis; Urinary system disease; Hemodialysis; Heart disease; Renal failure; Cardiovascular disease; kidney n transplant
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfm815

Background. Anaemia is common following renal transplantation and is associated with the development of congestive heart failure (CHF). However the prevalence of anaemia in the first year following transplantation and the association between anaemia occurring early and the development of CHF have been understudied. Methods. In this study, 132 incident patients undergoing tacrolimus and mycophenolate mofetil-based renal transplantation were studied for the prevalence of, and risk factors for, anaemia and CHF in the early period post transplantation. Results. Anaemia occurred in 94.5% and 53.1% of patients at 1 week and 12 months, respectively, and was associated with allograft dysfunction, hypoalbuminaemia, higher mycophenolic acid (MPA) levels, bacterial infection and hypoalbuminaemia. The association with hypoalbuminaemia may reflect the presence of chronic inflammation post-transplantation. Of patients displaying haemoglobin <11 g/dl, 41.1% and 29.4% were treated with erythropoiesis stimulating agents (ESAs) at 1 and 12 months respectively. CHF developed in 26 patients beyond 1 month post-transplantation, with echocardiographic left ventricular systolic function preserved in all but one. CHF was associated with anaemia and lower haemoglobin, allograft dysfunction, duration of dialysis and left ventricular hypertrophy on echocardiography prior to transplantation, suggesting the aetiology of CHF may involve the interplay of diastolic cardiac dysfunction, pre-load mismatch and after-load mismatch. Conclusions. Modification of risk factors may improve anaemia management post transplantation. Reducing the prevalence of anaemia may in turn reduce the incidence of CHF—these observations support the need for clinical trials to determine how anaemia management may impact CHF incidence.