Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus

• Published in: Neuroscience letters Vol. 566; pp. 111 - 114
• Main Authors: Bilella, Alessandro, Alvarez-Bolado, Gonzalo, Celio, Marco R.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30-04-2014
• Subjects: Animals; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Hypothalamic Area, Lateral - metabolism; Hypothalamic development; Immunohistochemistry; Medial forebrain bundle; Mice, Transgenic; Neurons - metabolism; Parvalbumins - genetics; Parvalbumins - metabolism; Periaqueductal grey; Stereology; MM; Immunohistochemistry; LM; Medial forebrain bundle; MP; 3v; Hypothalamic development; f; Periaqueductal grey; LHVL; Opt; PAG; Stereology; LH; vlt
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2014.02.028

•Foxb1-expressing neurons lie in the lateral hypothalamic PV1-nucleus.•Coaxial distribution of Foxb1- and PV-expressing neurons in the PV1-nucleus.•Foxb1-expressing neurons outnumber PV-expressing ones in the PV1-nucleus.•Only a small proportion of the two neural populations co-express both markers.
In the ventrolateral hypothalamus, the PV1-nucleus is defined by its population of parvalbumin-expressing neurons. During embryogenesis, the ventrolateral hypothalamus is colonized also by Foxb1-expressing neurons. In adult Foxb1-EGFP mice, many immunofluorescent neurons were found within the region that is occupied by the PV1-nucleus. They formed a cloud around the axial cord of the parvalbumin-immunopositive cells, which they greatly outnumber (3:1). Only a small proportion of the neurons in the PV1-nucleus co-expressed both parvalbumin and Foxb1. In the light of these findings, a redesignation of this lateral hypothalamic structure as the PV1-Foxb1 nucleus would more accurately reflect its specific biochemical properties.