Antivirals against Chikungunya Virus: Is the Solution in Nature?

The worldwide outbreaks of the chikungunya virus (CHIKV) in the last years demonstrated the need for studies to screen antivirals against CHIKV. The virus was first isolated in Tanzania in 1952 and was responsible for outbreaks in Africa and Southwest Asia in subsequent years. Between 2007 and 2014,...

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Bibliographic Details
Published in:	Viruses Vol. 12; no. 3; p. 272
Main Authors:	Martins, Daniel Oliveira Silva, Santos, Igor de Andrade, de Oliveira, Débora Moraes, Grosche, Victória Riquena, Jardim, Ana Carolina Gomes
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 29-02-2020 MDPI AG
Subjects:	antiviral Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological Products - chemistry Biological Products - pharmacology Biological Products - therapeutic use Chikungunya Fever - drug therapy Chikungunya Fever - virology chikungunya virus Chikungunya virus - drug effects Chikungunya virus - physiology Humans natural compounds Phytochemicals - chemistry Phytochemicals - pharmacology Phytochemicals - therapeutic use Review Structure-Activity Relationship Virus Replication - drug effects natural compounds antiviral chikungunya virus
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Summary:	The worldwide outbreaks of the chikungunya virus (CHIKV) in the last years demonstrated the need for studies to screen antivirals against CHIKV. The virus was first isolated in Tanzania in 1952 and was responsible for outbreaks in Africa and Southwest Asia in subsequent years. Between 2007 and 2014, some cases were documented in Europe and America. The infection is associated with low rates of death; however, it can progress to a chronic disease characterized by severe arthralgias in infected patients. This infection is also associated with Guillain-Barré syndrome. There is no specific antivirus against CHIKV. Treatment of infected patients is palliative and based on analgesics and non-steroidal anti-inflammatory drugs to reduce arthralgias. Several natural molecules have been described as antiviruses against viruses such as dengue, yellow fever, hepatitis C, and influenza. This review aims to summarize the natural compounds that have demonstrated antiviral activity against chikungunya virus in vitro.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v12030272