Potentiating effects of caffeine on the cardiovascular teratogenicity of ephedrine in chick embryos

Ephedrine was administered to 3-day chick embryos (Hamburger-Hamilton developmental stage 19) together with caffeine at doses where each agent alone caused minimal embryotoxicity. Embryos were examined for malformations on day 14 of incubation. The teratogenicity of ephedrine in the chick cardiovasc...

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Bibliographic Details
Published in:	Toxicology letters Vol. 29; no. 1; p. 65
Main Authors:	Nishikawa, T, Bruyere, Jr, H J, Gilbert, E F, Takagi, Y
Format:	Journal Article
Language:	English
Published:	Netherlands 01-12-1985
Subjects:	Animals Caffeine - toxicity Cardiovascular Abnormalities Cardiovascular System - drug effects Cardiovascular System - embryology Chick Embryo Drug Synergism Ephedrine - toxicity Teratogens
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Summary:	Ephedrine was administered to 3-day chick embryos (Hamburger-Hamilton developmental stage 19) together with caffeine at doses where each agent alone caused minimal embryotoxicity. Embryos were examined for malformations on day 14 of incubation. The teratogenicity of ephedrine in the chick cardiovascular system was significantly potentiated by caffeine at a dose as low as 0.5 mumol (0.1 mg/egg; 2 mg/kg egg).
ISSN:	0378-4274
DOI:	10.1016/0378-4274(85)90201-2