Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress
The endoplasmic reticulum (ER) is a major site of protein synthesis, most strikingly in the specialized secretory cells of metazoans, which can produce their own weight in proteins daily. Cells possess a diverse machinery to ensure correct folding, assembly, and secretion of proteins from the ER. Wh...
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| Published in: | American Journal of Physiology: Cell Physiology Vol. 307; no. 8; p. C657 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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United States
15-10-2014
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| Abstract | The endoplasmic reticulum (ER) is a major site of protein synthesis, most strikingly in the specialized secretory cells of metazoans, which can produce their own weight in proteins daily. Cells possess a diverse machinery to ensure correct folding, assembly, and secretion of proteins from the ER. When this machinery is overwhelmed, the cell is said to experience ER stress, a result of the accumulation of unfolded or misfolded proteins in the lumen of the organelle. Here we discuss the causes of ER stress and the mechanisms by which cells elicit a response, with an emphasis on recent discoveries. |
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| AbstractList | The endoplasmic reticulum (ER) is a major site of protein synthesis, most strikingly in the specialized secretory cells of metazoans, which can produce their own weight in proteins daily. Cells possess a diverse machinery to ensure correct folding, assembly, and secretion of proteins from the ER. When this machinery is overwhelmed, the cell is said to experience ER stress, a result of the accumulation of unfolded or misfolded proteins in the lumen of the organelle. Here we discuss the causes of ER stress and the mechanisms by which cells elicit a response, with an emphasis on recent discoveries. |
| Author | Chambers, Joseph E Marciniak, Stefan J |
| Author_xml | – sequence: 1 givenname: Joseph E surname: Chambers fullname: Chambers, Joseph E email: jec202@cam.ac.uk, sjm20@cam.ac.uk organization: Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom jec202@cam.ac.uk sjm20@cam.ac.uk – sequence: 2 givenname: Stefan J surname: Marciniak fullname: Marciniak, Stefan J organization: Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24944205$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Endoplasmic Reticulum Stress Endoplasmic Reticulum-Associated Degradation Heat-Shock Proteins - physiology Humans Oxidative Stress Protein Folding Proteolysis Proteostasis Deficiencies - metabolism Signal Transduction |
| Title | Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress |
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