Functional deficit of sperm and fertility impairment in men with antisperm antibodies

Highlights • Men with MAR-IgG ≥ 50% can be fertile but all MAR-IgG > 12% cases are outliers. • In normozoospermia, there are 16% cases of immune infertility. • ASA-positive infertile men have a higher rate of impaired AR and inducibility. • ASA-positive infertile men have a higher rate of DNA fra...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of reproductive immunology Vol. 112; pp. 95 - 101
Main Authors:	Bozhedomov, V.A, Nikolaeva, M.A, Ushakova, I.V, Lipatova, N.A, Bozhedomova, G.E, Sukhikh, G.T
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-11-2015
Subjects:	Acrosome reaction Acrosome Reaction - immunology Adult Antisperm antibodies Autoantibodies - immunology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Cross-Sectional Studies DNA Fragmentation Humans Immunoglobulin G - immunology Infertility, Male - immunology Infertility, Male - pathology Male Middle Aged Normozoospermia Obstetrics and Gynecology Reactive oxygen species Reactive Oxygen Species - immunology Retrospective Studies Sperm DNA fragmentation Spermatozoa - immunology CPM ROS counted as photons per minute DFI sperm chromatin structure assay ASA ICSI reactive oxygen species in vitro fertilization capacitation WHO straight-line (rectilinear) velocity World Health Organization immunoglobulin OS intraсytoplasmic sperm injection acrosome reaction DNA fragmentation index Sperm DNA fragmentation sperm chromatin dispersion VSL AR curvilinear velocity CAP mixed antiglobulin reaction SCD ROS IVF SCSA amplitude of lateral head displacement ALH Normozoospermia antisperm antibodies Ig oxidative stress VCL MAR Reactive oxygen species Antisperm antibodies Acrosome reaction
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights • Men with MAR-IgG ≥ 50% can be fertile but all MAR-IgG > 12% cases are outliers. • In normozoospermia, there are 16% cases of immune infertility. • ASA-positive infertile men have a higher rate of impaired AR and inducibility. • ASA-positive infertile men have a higher rate of DNA fragmentation. • ASA-positive washed sperm cells produce higher ROS levels that depend on ASA levels.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.08.002