Inhibitory and stimulatory effects of phorbol ester on vasopressin-induced cellular responses in cultured rat aortic smooth muscle cells

In rat aortic smooth muscle cells, vasopressin (AVP) induces prostacyclin (PGI2) production, probably as the consequence of phospholipase C activation. Our study analyzes the effects of phorbol 12-myristate 13-acetate (PMA)-induced protein kinase C (PKC) activation on AVP-induced inositol 1,4,5-tris...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 265; no. 18; pp. 10451 - 10457
Main Authors:	CHARDONNENS, D, LANG, U, ROSSIER, M. F, CAPPONI, A. M, VALLOTTON, M. B
Format:	Journal Article
Language:	English
Published:	Bethesda, MD American Society for Biochemistry and Molecular Biology 25-06-1990
Subjects:	Alkaloids - pharmacology Animals Aorta - drug effects Aorta - metabolism Arginine Vasopressin - antagonists & inhibitors Arginine Vasopressin - pharmacology Biological and medical sciences Calcimycin - pharmacology Calcium - metabolism Cell physiology Cells, Cultured Cytosol - enzymology Drug Synergism Enzyme Activation Epoprostenol - biosynthesis Female Fundamental and applied biological sciences. Psychology Inositol 1,4,5-Trisphosphate - metabolism Kinetics Molecular and cellular biology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism phorbol 12-myristate 13-acetate diester prostacyclin Protein Kinase C - metabolism Rats Rats, Inbred Strains Signal transduction smooth muscle Staurosporine Tetradecanoylphorbol Acetate - pharmacology vasopressin Signal transduction Vertebrata Protein kinase C Mammalia Calcium Prostaglandin I2 Rat Rodentia Aorta Smooth muscle Inositol phosphate Vasopressin
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