Activation of adenosine A3 receptors regulates vitamin C transport and redox balance in neurons

Adenosine is an important neuromodulator in the CNS, regulating neuronal survival and synaptic transmission. The antioxidant ascorbate (the reduced form of vitamin C) is concentrated in CNS neurons through a sodium-dependent transporter named SVCT2 and participates in several CNS processes, for inst...

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Bibliographic Details

Published in:	Free radical biology & medicine Vol. 163; pp. 43 - 55
Main Authors:	Portugal, Camila C., da Encarnação, Thaísa G., Sagrillo, Mayara A., Pereira, Mariana R., Relvas, João B., Socodato, Renato, Paes-de-Carvalho, Roberto
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2021
Subjects:	Ascorbate Oxidative signaling Purinergic signaling Reactive oxygen species (ROS) Retina SVCT2 Transporter reversion SVCT2 Reactive oxygen species (ROS) Retina Ascorbate Oxidative signaling Transporter reversion Purinergic signaling
Online Access:	Get full text
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