Deciphering and shaping bacterial diversity through CRISPR

Highlights • CRISPR-Cas generates diversity through phage–host genome evolution. • Cytotoxic self-targeting is highly lethal and alters bacterial population composition. • Information stored in CRISPR loci provide a genetic snapshot of microbial and viral diversity.

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Bibliographic Details
Published in:	Current opinion in microbiology Vol. 31; pp. 101 - 108
Main Authors:	Briner, Alexandra E, Barrangou, Rodolphe
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2016
Subjects:	Bacteria Bacteria - genetics Bacteria - virology Bacteriophages - genetics Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Cas Systems - genetics Genome, Bacterial - genetics Host-Pathogen Interactions - genetics Pathology
Online Access:	Get full text
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Description
Summary:	Highlights • CRISPR-Cas generates diversity through phage–host genome evolution. • Cytotoxic self-targeting is highly lethal and alters bacterial population composition. • Information stored in CRISPR loci provide a genetic snapshot of microbial and viral diversity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.03.006