Biomarkers for the Diagnosis of Cholangiocarcinoma: A Systematic Review
Cholangiocarcinoma (CCA), a malignant tumor of the bile duct, is a major public health problem in many Southeast Asian countries, particularly Thailand. The slow progression makes it difficult for early diagnosis and most patients are detected in advanced stages. This study aimed to review all relev...
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| Published in: | The American journal of tropical medicine and hygiene Vol. 98; no. 6; pp. 1788 - 1797 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Institute of Tropical Medicine
01-01-2018
The American Society of Tropical Medicine and Hygiene |
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| Abstract | Cholangiocarcinoma (CCA), a malignant tumor of the bile duct, is a major public health problem in many Southeast Asian countries, particularly Thailand. The slow progression makes it difficult for early diagnosis and most patients are detected in advanced stages. This study aimed to review all relevant articles related to the biomarkers for the diagnosis of CCA and point out potential biomarkers. A thorough search was performed in PubMed and ScienceDirect for CCA biomarker articles. Required data were extracted. A total of 46 articles that fulfilled the inclusion and had none of the exclusion criteria were included in the analysis (17, 22, 3, 4, and 1 articles on blood, tissue, bile, both blood and tissue, and urine biomarkers, respectively). Carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA), either alone or in combination with other biomarkers, are the most commonly studied biomarkers in the serum. Their sensitivity and specificity ranged from 47.2% to 98.2% and 89.7% to 100%, respectively. However, in the tissue, gene methylations and DNA-related markers were the most studied CCA biomarkers. Their sensitivity and specificity ranged from 58% to 87% and 98% to 100%, respectively. Some articles investigated biomarkers both in blood and tissues, particularly CA19-9 and CEA, with sensitivity and specificity ranging from 33% to 100% and 50% to 97.7%, respectively. Although quite a number of biomarkers with a potential role in the early detection of CCA have been established, it is difficult to single out any particular marker that could be used in the routine clinical settings. |
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| AbstractList | Cholangiocarcinoma (CCA), a malignant tumor of the bile duct, is a major public health problem in many Southeast Asian countries, particularly Thailand. The slow progression makes it difficult for early diagnosis and most patients are detected in advanced stages. This study aimed to review all relevant articles related to the biomarkers for the diagnosis of CCA and point out potential biomarkers. A thorough search was performed in PubMed and ScienceDirect for CCA biomarker articles. Required data were extracted. A total of 46 articles that fulfilled the inclusion and had none of the exclusion criteria were included in the analysis (17, 22, 3, 4, and 1 articles on blood, tissue, bile, both blood and tissue, and urine biomarkers, respectively). Carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA), either alone or in combination with other biomarkers, are the most commonly studied biomarkers in the serum. Their sensitivity and specificity ranged from 47.2% to 98.2% and 89.7% to 100%, respectively. However, in the tissue, gene methylations and DNA-related markers were the most studied CCA biomarkers. Their sensitivity and specificity ranged from 58% to 87% and 98% to 100%, respectively. Some articles investigated biomarkers both in blood and tissues, particularly CA19-9 and CEA, with sensitivity and specificity ranging from 33% to 100% and 50% to 97.7%, respectively. Although quite a number of biomarkers with a potential role in the early detection of CCA have been established, it is difficult to single out any particular marker that could be used in the routine clinical settings. |
| Author | Tshering, Gyem Chaijaroenkul, Wanna Dorji, Palden Wangyel Na-Bangchang, Kesara |
| Author_xml | – sequence: 1 givenname: Gyem surname: Tshering fullname: Tshering, Gyem organization: Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani, Thailand – sequence: 2 givenname: Palden Wangyel surname: Dorji fullname: Dorji, Palden Wangyel organization: Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani, Thailand – sequence: 3 givenname: Wanna surname: Chaijaroenkul fullname: Chaijaroenkul, Wanna organization: Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani, Thailand – sequence: 4 givenname: Kesara surname: Na-Bangchang fullname: Na-Bangchang, Kesara organization: Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Klong Luang, Pathum Thani, Thailand |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29637880$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors’ addresses: Gyem Tshering, Palden Wangyel Dorji, and Wanna Chaijaroenkul, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Pathum Thani, Thailand, E-mails: wangten_gyem@hotmail.com, paldenwangyal@yahoo.com, and wn_ap39@yahoo.com. Kesara Na-Bangchang, Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Rangsit Center, Pathum Thani, Thailand, E-mail: kesaratmu@yahoo.com. |
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| References | Park (b109) 2011; 458 Tanimura (b29) 2005; 219 Flamini (b87) 2006; 12 Sato (b69) 2012; 180 Mayer (b102) 2005; 62 Brychtova (b43) 2014; 96 Metzger (b59) 2013; 62 Alvaro (b119) 2009; 25 Malesci (b86) 1987; 92 Wang (b94) 2012; 36 Wang (b81) 2015; 6 Ben-Menachem (b115) 2007; 19 Elkins (b1) 1996; 55 Meng (b91) 2006; 130 Nischalke (b62) 2012; 7 Monsouvanh (b60) 2014; 15 Correa-Gallego (b47) 2016; 11 Anderson (b13) 2004; 9 Todoroki (b20) 1999; 46 Subrungruanga (b24) 2013; 14 Desmetz (b38) 2011; 15 Park (b116) 1999; 30 Shin (b71) 2012; 14 Tao (b75) 2010; 76 Kisiel (b51) 2013; 4 Bjornsson (b118) 2007; 45 Feldmann (b46) 2006; 38 Matsuda (b57) 2010; 52 Prayong (b8) 2014; 15 Bjornsson (b42) 1999; 19 Brooks (b107) 2009; 20 Steinberg (b120) 1990; 85 Mon (b27) 2009; 512 Zen (b79) 2014; 65 Pinlaor (b2) 2003; 309 Bengala (b18) 2010; 102 Haswell-Elkins (b7) 1992; 8 Vatanasapt (b4) 2002; 32 (Suppl) Ramage (b67) 1995; 108 Rucksaken (b68) 2014; 9 Hooper (b48) 2012; 43 Khoontawad (b50) 2014; 35 Kraiklang (b52) 2014; 9 Sabirzhanov (b101) 2012; 123 Bertram (b41) 2016; 69 Shi (b70) 2013; 17 Palumbo (b112) 2002; 25 Valle (b17) 2010; 362 Li (b53) 2009; 41 Nakagohri (b21) 2008; 32 Patel (b32) 2000; 95 Boncinelli (b113) 1997; 7 Patel (b11) 2001; 33 Du (b45) 2016; 50 Adisakwattana (b23) 2015; 16 Selaru (b83) 2009; 49 Takada (b16) 2002; 95 Yang (b78) 2015; 23 Ince (b111) 2000; 60 Sloane (b98) 1990; 1 Sudan (b15) 2002; 2 Lumachi (b56) 2014; 34 Tit-Oon (b37) 2014; 45 Todoroki (b19) 2000; 46 Agrawal (b117) 2007; 11 Augustin (b103) 2009; 10 Levy (b30) 2005; 50 Hatziapostolou (b106) 2011; 68 Hanahan (b105) 2011; 144 Belinsky (b108) 2004; 4 Patsenker (b65) 2010; 52 Silsirivanit (b72) 2013; 104 Siqueira (b73) 2002; 56 Busse-Wicher (b96) 2014; 35 Khuhaprema (b5) 2010 Ng (b95) 2009; 58 Staab (b88) 1982; 45 Khan (b12) 2012; 56 Tang (b104) 2006; 15 Srisomsap (b35) 2004; 4 Tan (b74) 2010; 126 Meyer (b14) 2000; 69 Srisomsap (b36) 2010; 2010 Loilome (b34) 2006; 45 Li (b54) 2015; 16 Nishino (b63) 2008; 49 Mach (b97) 1992; 282 Qin (b33) 2004; 10 Pungpak (b31) 1991; 85 Voigtlander (b84) 2015; 10 Charatcharoenwitthaya (b44) 2008; 48 Faca (b25) 2009; 69 Matsuda (b58) 2013; 85 Tolek (b76) 2012; 237 Montomoli (b10) 2011; 3 (Suppl 1) Korioth (b110) 1994; 150 Andresen (b39) 2012; 7 Silakit (b93) 2014; 21 Bernuzzi (b80) 2016; 185 Chen (b90) 2009; 50 Loilome (b22) 2012; 61 Li (b82) 2014; 60 Nagai (b100) 2003; 329 Liu (b55) 2008; 104 Wang (b92) 2015; 5 Magnani (b85) 1983; 43 Ono (b64) 2016; 469 Goonetilleke (b121) 2007; 33 Yothaisong (b9) 2014; 15 Cummins (b89) 2006; 25 Pattanapairoj (b66) 2015; 48 Calkins (b99) 1995; 376 Jahng (b49) 2009; 41 Cillo (b114) 2001; 188 Thamavit (b3) 1978; 38 Pinlaor (b28) 2010; 638 Navaneethan (b61) 2015; 60 Voigtlander (b77) 2014; 9 Briggs (b26) 2009; 45 Andresen (b40) 2015; 61 Chainuvati (b6) 1976; 7 |
| References_xml | – volume: 38 start-page: 604 year: 2006 ident: b46 article-title: Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer contributor: fullname: Feldmann – volume: 56 start-page: 40 year: 2002 ident: b73 article-title: Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis contributor: fullname: Siqueira – volume: 69 start-page: 619 year: 2016 ident: b41 article-title: Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions contributor: fullname: Bertram – volume: 52 start-page: 174 year: 2010 ident: b57 article-title: Wisteria floribunda agglutinin-positive mucin 1 is a sensitive biliary marker for human cholangiocarcinoma contributor: fullname: Matsuda – volume: 43 start-page: 5489 year: 1983 ident: b85 article-title: Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin contributor: fullname: Magnani – volume: 12 start-page: 6985 year: 2006 ident: b87 article-title: Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer contributor: fullname: Flamini – volume: 61 start-page: 1651 year: 2015 ident: b40 article-title: Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma contributor: fullname: Andresen – volume: 21 start-page: 864 year: 2014 ident: b93 article-title: Circulating miR-192 in liver fluke-associated cholangiocarcinoma patients: a prospective prognostic indicator contributor: fullname: Silakit – volume: 50 start-page: 358 year: 2009 ident: b90 article-title: The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma contributor: fullname: Chen – volume: 62 start-page: 670 year: 2005 ident: b102 article-title: Hsp70 chaperones: cellular functions and molecular mechanism contributor: fullname: Mayer – volume: 188 start-page: 161 year: 2001 ident: b114 article-title: Homeobox genes in normal and malignant cells contributor: fullname: Cillo – volume: 16 start-page: 3849 year: 2015 ident: b23 article-title: ALCAM is a novel cytoplasmic membrane protein in TNF-α stimulated invasive cholangiocarcinoma cells contributor: fullname: Adisakwattana – volume: 15 start-page: 9511 year: 2014 ident: b60 article-title: Serum cathepsin B to cystatin C ratio as a potential marker for the diagnosis of cholangiocarcinoma contributor: fullname: Monsouvanh – volume: 55 start-page: 295 year: 1996 ident: b1 article-title: Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans contributor: fullname: Elkins – volume: 19 start-page: 501 year: 1999 ident: b42 article-title: CA 19-9 and CEA are unreliable markers for cholangiocarcinoma in patients with primary sclerosing cholangitis contributor: fullname: Bjornsson – volume: 35 start-page: 1029 year: 2014 ident: b50 article-title: Increase of exostosin 1 in plasma as a potential biomarker for opisthorchiasis-associated cholangiocarcinoma contributor: fullname: Khoontawad – volume: 65 start-page: 784 year: 2014 ident: b79 article-title: Tubulin β-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma contributor: fullname: Zen – volume: 30 start-page: 1128 year: 1999 ident: b116 article-title: Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line contributor: fullname: Park – volume: 10 start-page: e0139305 year: 2015 ident: b84 article-title: MicroRNAs in serum and bile of patients with primary sclerosing cholangitis and/or cholangiocarcinoma contributor: fullname: Voigtlander – volume: 49 start-page: 207 year: 2008 ident: b63 article-title: Identification of novel candidate tumor marker genes for intrahepatic cholangiocarcinoma contributor: fullname: Nishino – volume: 92 start-page: 60 year: 1987 ident: b86 article-title: Determination of CA 19-9 antigen in serum and pancreatic juice for differential diagnosis of pancreatic adenocarcinoma from chronic pancreatitis contributor: fullname: Malesci – volume: 85 start-page: 1 year: 2013 ident: b58 article-title: Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma contributor: fullname: Matsuda – volume: 33 start-page: 1353 year: 2001 ident: b11 article-title: Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States contributor: fullname: Patel – volume: 20 start-page: 1539 year: 2009 ident: b107 article-title: Promoter methylation and the detection of breast cancer contributor: fullname: Brooks – volume: 25 start-page: 39 year: 2002 ident: b112 article-title: Human aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies: potential biomarkers for pancreatic carcinoma contributor: fullname: Palumbo – volume: 123 start-page: 542 year: 2012 ident: b101 article-title: Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis contributor: fullname: Sabirzhanov – volume: 68 start-page: 1681 year: 2011 ident: b106 article-title: Epigenetic aberrations during oncogenesis contributor: fullname: Hatziapostolou – volume: 46 start-page: 581 year: 2000 ident: b19 article-title: Benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma contributor: fullname: Todoroki – volume: 17 start-page: 1584 year: 2013 ident: b70 article-title: A prospective proteomic-based study for identifying potential biomarkers for the diagnosis of cholangiocarcinoma contributor: fullname: Shi – volume: 7 start-page: 331 year: 1997 ident: b113 article-title: Homeobox genes and disease contributor: fullname: Boncinelli – volume: 46 start-page: 1585 year: 1999 ident: b20 article-title: Benefits of combining radiotherapy with aggressive resection for stage IV gallbladder cancer contributor: fullname: Todoroki – volume: 96 start-page: 375 year: 2014 ident: b43 article-title: Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma contributor: fullname: Brychtova – volume: 50 start-page: 501 year: 2016 ident: b45 article-title: Differential diagnosis of immunoglobulin G4-associated cholangitis from cholangiocarcinoma contributor: fullname: Du – volume: 36 start-page: e61 year: 2012 ident: b94 article-title: Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis contributor: fullname: Wang – volume: 45 start-page: 2108 year: 2014 ident: b37 article-title: Comparative secretome analysis of cholangiocarcinoma cell line in three-dimensional culture contributor: fullname: Tit-Oon – volume: 62 start-page: 122 year: 2013 ident: b59 article-title: Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders contributor: fullname: Metzger – volume: 19 start-page: 615 year: 2007 ident: b115 article-title: Risk factors for cholangiocarcinoma contributor: fullname: Ben-Menachem – volume: 3 (Suppl 1) start-page: 3 year: 2011 ident: b10 article-title: Survival of patients with primary liver cancer in central and northern Denmark, 1998–2009 contributor: fullname: Montomoli – volume: 49 start-page: 1595 year: 2009 ident: b83 article-title: MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3 contributor: fullname: Selaru – volume: 15 start-page: 2013 year: 2011 ident: b38 article-title: Autoantibody signatures: progress and perspectives for early cancer detection contributor: fullname: Desmetz – volume: 34 start-page: 6663 year: 2014 ident: b56 article-title: Measurement of serum carcinoembryonic antigen, carbohydrate antigen 19-9, cytokeratin-19 fragment and matrix metalloproteinase-7 for detecting cholangiocarcinoma: a preliminary case-control study contributor: fullname: Lumachi – volume: 4 start-page: 1135 year: 2004 ident: b35 article-title: Proteomic analysis of cholangiocarcinoma cell line contributor: fullname: Srisomsap – volume: 4 start-page: 1000145 year: 2013 ident: b51 article-title: Methylated bone morphogenetic protein 3 (BMP3) gene: evaluation of tumor suppressor function and biomarker potential in biliary cancer contributor: fullname: Kisiel – volume: 638 start-page: 134 year: 2010 ident: b28 article-title: Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment contributor: fullname: Pinlaor – volume: 45 start-page: 1547 year: 2007 ident: b118 article-title: Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literature contributor: fullname: Bjornsson – volume: 16 start-page: 3451 year: 2015 ident: b54 article-title: Application of joint detection of AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma contributor: fullname: Li – volume: 43 start-page: 1583 year: 2012 ident: b48 article-title: The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma contributor: fullname: Hooper – volume: 56 start-page: 848 year: 2012 ident: b12 article-title: Rising trends in cholangiocarcinoma: is the ICD classification system misleading us? contributor: fullname: Khan – year: 2010 ident: b5 contributor: fullname: Khuhaprema – volume: 41 start-page: 605 year: 2009 ident: b53 article-title: Clinical significance of serum tumor M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma contributor: fullname: Li – volume: 58 start-page: 1375 year: 2009 ident: b95 article-title: Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening contributor: fullname: Ng – volume: 69 start-page: 1633 year: 2000 ident: b14 article-title: Liver transplantation for cholangiocarcinoma: results in 207 patients contributor: fullname: Meyer – volume: 102 start-page: 68 year: 2010 ident: b18 article-title: Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial contributor: fullname: Bengala – volume: 144 start-page: 646 year: 2011 ident: b105 article-title: Hallmarks of cancer: the next generation contributor: fullname: Hanahan – volume: 11 start-page: 445 year: 2007 ident: b117 article-title: CD24 expression is an independent prognostic marker in cholangiocarcinoma contributor: fullname: Agrawal – volume: 61 start-page: 136 year: 2012 ident: b22 article-title: Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis contributor: fullname: Loilome – volume: 469 start-page: 417 year: 2016 ident: b64 article-title: Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma contributor: fullname: Ono – volume: 25 start-page: 6220 year: 2006 ident: b89 article-title: Implications of micro-RNA profiling for cancer diagnosis contributor: fullname: Cummins – volume: 362 start-page: 1273 year: 2010 ident: b17 article-title: Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer contributor: fullname: Valle – volume: 23 start-page: 19 year: 2015 ident: b78 article-title: The utility of villin and mammaglobin in the differential diagnosis between intrahepatic cholangiocarcinoma and breast cancer contributor: fullname: Yang – volume: 8 start-page: 86 year: 1992 ident: b7 article-title: Opisthorchis viverrini and cholangiocarcinoma in northeast Thailand contributor: fullname: Haswell-Elkins – volume: 10 start-page: 427 year: 2004 ident: b33 article-title: Utility of serum CA19-9 in diagnosis of cholangiocarcinoma: in comparison with CEA contributor: fullname: Qin – volume: 15 start-page: 525 year: 2006 ident: b104 article-title: Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance contributor: fullname: Tang – volume: 60 start-page: 903 year: 2015 ident: b61 article-title: Comparative effectiveness of pyruvate kinase M2 in bile, serum carbohydrate antigen 19-9, and biliary brushings in diagnosing malignant biliary strictures contributor: fullname: Navaneethan – volume: 309 start-page: 567 year: 2003 ident: b2 article-title: 8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini contributor: fullname: Pinlaor – volume: 104 start-page: 1278 year: 2013 ident: b72 article-title: CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma contributor: fullname: Silsirivanit – volume: 9 start-page: e97046 year: 2014 ident: b77 article-title: Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinoma contributor: fullname: Voigtlander – volume: 108 start-page: 865 year: 1995 ident: b67 article-title: Serum tumor markers for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis contributor: fullname: Ramage – volume: 329 start-page: 53 year: 2003 ident: b100 article-title: Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis contributor: fullname: Nagai – volume: 45 start-page: 279 year: 2006 ident: b34 article-title: Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model contributor: fullname: Loilome – volume: 41 start-page: 965 year: 2009 ident: b49 article-title: Staining for intracytoplasmic lumina and CAM5.2 increases the detection rate for bile duct cancers contributor: fullname: Jahng – volume: 35 start-page: 25 year: 2014 ident: b96 article-title: The exostosin family: proteins with many functions contributor: fullname: Busse-Wicher – volume: 7 start-page: 482 year: 1976 ident: b6 article-title: Carcinoma of the cystic duct associated with opisthorchiasis contributor: fullname: Chainuvati – volume: 60 start-page: 896 year: 2014 ident: b82 article-title: Human bile contains microRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis contributor: fullname: Li – volume: 130 start-page: 2113 year: 2006 ident: b91 article-title: Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines contributor: fullname: Meng – volume: 14 start-page: 557 year: 2013 ident: b24 article-title: Gene expression profiling of intrahepatic cholangiocarcinoma contributor: fullname: Subrungruanga – volume: 10 start-page: 165 year: 2009 ident: b103 article-title: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system contributor: fullname: Augustin – volume: 38 start-page: 4634 year: 1978 ident: b3 article-title: Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters contributor: fullname: Thamavit – volume: 85 start-page: 277 year: 1991 ident: b31 article-title: Tumor markers in the detection of opisthorchiasis-associated cholangiocarcinoma contributor: fullname: Pungpak – volume: 237 start-page: 1142 year: 2012 ident: b76 article-title: Serum alpha1beta-glycoprotein and afamin ratio as potential diagnostic and prognostic markers in cholangiocarcinoma contributor: fullname: Tolek – volume: 376 start-page: 71 year: 1995 ident: b99 article-title: Mammalian cysteine protease inhibitors: biochemical properties and possible roles in tumor progression contributor: fullname: Calkins – volume: 32 start-page: 2675 year: 2008 ident: b21 article-title: Surgical outcome and prognostic factors in intrahepatic cholangiocarcinoma contributor: fullname: Nakagohri – volume: 9 start-page: 43 year: 2004 ident: b13 article-title: Diagnosis and treatment of cholangiocarcinoma contributor: fullname: Anderson – volume: 7 start-page: e42141 year: 2012 ident: b62 article-title: Detection of IGF2BP3, HOXB7, and NEK2 mRNA expression in brush cytology specimens as a new diagnostic tool in patients with biliary strictures contributor: fullname: Nischalke – volume: 95 start-page: 1685 year: 2002 ident: b16 article-title: Is postoperative adjuvant chemotherapy useful for gallbladder carcinoma? A phase III multicenter prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma contributor: fullname: Takada – volume: 512 start-page: 279 year: 2009 ident: b27 article-title: Inflammation and tumor progression: a lesson from TNF-alpha-dependent FAK signaling in cholangiocarcinoma doi: 10.1007/978-1-60327-530-9_15 contributor: fullname: Mon – volume: 458 start-page: 73 year: 2011 ident: b109 article-title: Promoter CpG island hypermethylation during breast cancer progression contributor: fullname: Park – volume: 95 start-page: 204 year: 2000 ident: b32 article-title: The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis contributor: fullname: Patel – volume: 9 start-page: e89337 year: 2014 ident: b52 article-title: A novel predictive equation for potential diagnosis of cholangiocarcinoma contributor: fullname: Kraiklang – volume: 48 start-page: 668 year: 2015 ident: b66 article-title: Improve discrimination power of serum markers for diagnosis of cholangiocarcinoma using data mining-based approach contributor: fullname: Pattanapairoj – volume: 60 start-page: 1261 year: 2000 ident: b111 article-title: Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation contributor: fullname: Ince – volume: 1 start-page: 137 year: 1990 ident: b98 article-title: Cathepsin B and cystatins: evidence for a role in cancer progression contributor: fullname: Sloane – volume: 2010 start-page: 437143 year: 2010 ident: b36 article-title: Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes contributor: fullname: Srisomsap – volume: 4 start-page: 707 year: 2004 ident: b108 article-title: Gene-promoter hypermethylation as a biomarker in lung cancer contributor: fullname: Belinsky – volume: 32 (Suppl) start-page: S82 year: 2002 ident: b4 article-title: Cancer control in Thailand contributor: fullname: Vatanasapt – volume: 45 start-page: 718 year: 1982 ident: b88 article-title: Prognostic value of preoperative serum CEA level compared to clinical staging: II. Stomach cancer contributor: fullname: Staab – volume: 14 start-page: 256 year: 2012 ident: b71 article-title: Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity contributor: fullname: Shin – volume: 69 start-page: 728 year: 2009 ident: b25 article-title: In-depth proteomics to define the cell surface and secretome of ovarian cancer cells and processes of protein shedding contributor: fullname: Faca – volume: 104 start-page: 745 year: 2008 ident: b55 article-title: Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma contributor: fullname: Liu – volume: 15 start-page: 5443 year: 2014 ident: b8 article-title: An interleukin-6 receptor polymorphism is associated with opisthorchiasis-linked cholangiocarcinoma risk in Thailand contributor: fullname: Prayong – volume: 6 start-page: 18631 year: 2015 ident: b81 article-title: Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma contributor: fullname: Wang – volume: 15 start-page: 10463 year: 2014 ident: b9 article-title: Opisthorchis viverrini infection activates the PI3K/AKT/PTEN and Wnt/β-catenin signaling pathways in a cholangiocarcinogenesis model contributor: fullname: Yothaisong – volume: 50 start-page: 1734 year: 2005 ident: b30 article-title: The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis contributor: fullname: Levy – volume: 7 start-page: 1249 year: 2012 ident: b39 article-title: Novel target genes and a valid biomarker panel identified for cholangiocarcinoma contributor: fullname: Andresen – volume: 52 start-page: 362 year: 2010 ident: b65 article-title: The alphavbeta6 integrin is a highly specific immunohistochemical marker for cholangiocarcinoma contributor: fullname: Patsenker – volume: 11 start-page: e0163699 year: 2016 ident: b47 article-title: Circulating plasma levels of microRNA-21 and microRNA-221 are potential diagnostic markers for primary intrahepatic cholangiocarcinoma contributor: fullname: Correa-Gallego – volume: 126 start-page: 2353 year: 2010 ident: b74 article-title: p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion contributor: fullname: Tan – volume: 76 start-page: 1210 year: 2010 ident: b75 article-title: Comparison of serum tumor markers for intrahepatic cholangiocarcinoma and hepatocellular carcinoma contributor: fullname: Tao – volume: 5 start-page: 7610 year: 2015 ident: b92 article-title: A panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma contributor: fullname: Wang – volume: 33 start-page: 266 year: 2007 ident: b121 article-title: Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer contributor: fullname: Goonetilleke – volume: 180 start-page: 123 year: 2012 ident: b69 article-title: Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma contributor: fullname: Sato – volume: 219 start-page: 205 year: 2005 ident: b29 article-title: Tumor necrosis factor alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2 contributor: fullname: Tanimura – volume: 48 start-page: 1106 year: 2008 ident: b44 article-title: Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis contributor: fullname: Charatcharoenwitthaya – volume: 185 start-page: 61 year: 2016 ident: b80 article-title: Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma contributor: fullname: Bernuzzi – volume: 85 start-page: 350 year: 1990 ident: b120 article-title: The clinical utility of the CA 19-9 tumor-associated antigen contributor: fullname: Steinberg – volume: 2 start-page: 774 year: 2002 ident: b15 article-title: Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma contributor: fullname: Sudan – volume: 9 start-page: e103259 year: 2014 ident: b68 article-title: Plasma autoantibodies against heat shock protein 70, enolase 1 and ribonuclease/angiogenin inhibitor 1 as potential biomarkers for cholangiocarcinoma contributor: fullname: Rucksaken – volume: 282 start-page: 577 year: 1992 ident: b97 article-title: Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme contributor: fullname: Mach – volume: 150 start-page: 395 year: 1994 ident: b110 article-title: Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase contributor: fullname: Korioth – volume: 45 start-page: 33 year: 2009 ident: b26 article-title: Prognostic molecular markers in cholangiocarcinoma: a systematic review contributor: fullname: Briggs – volume: 25 start-page: 279 year: 2009 ident: b119 article-title: Serum and bile biomarkers for cholangiocarcinoma contributor: fullname: Alvaro |
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| Snippet | Cholangiocarcinoma (CCA), a malignant tumor of the bile duct, is a major public health problem in many Southeast Asian countries, particularly Thailand. The... |
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| Title | Biomarkers for the Diagnosis of Cholangiocarcinoma: A Systematic Review |
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