Two new flavones glycosides with antimicrobial activities from Clerodendrum formicarum Gürke (Lamiaceae)

• Published in: Natural product research Vol. 35; no. 6; pp. 951 - 959
• Main Authors: Mahamat, Achi, Gbaweng, Abel Joel Yaya, Tagatsing Fotsing, Maurice, Talla, Emmanuel, Fekam, Fabrice Boyom, Henoumont, Celine, Sophie, Laurent, Mbafor, Joseph Tanyi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19-03-2021; Taylor & Francis Ltd
• Subjects: Acetic acid; Anti-Infective Agents - pharmacology; Antibacterial activity; antimicrobial; Carbon-13 Magnetic Resonance Spectroscopy; Clerodendrum; Clerodendrum - chemistry; Clerodendrum formicarum; Column chromatography; Ethyl acetate; flavone; Flavones; Flavones - chemistry; Flavones - pharmacology; Fungi; Glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Herbal medicine; Lamiaceae; Medicinal plants; Methanol; Microbial Sensitivity Tests; Microorganisms; Minimum inhibitory concentration; Phytochemicals - pharmacology; Plant Extracts - chemistry; Plant Leaves - chemistry; Proton Magnetic Resonance Spectroscopy; Spectroscopy; Staphylococcus aureus; Staphylococcus aureus - drug effects; Clerodendrum formicarum; antimicrobial; Lamiaceae; flavone
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1613397

Clerodendrum formicarum Gürke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a (3) and clerodendronone 1b (4) along with two known compounds: 5,7-dihydroxy-4′-methoxyflavone (1) and 5-hydroxy-7,4′-dimethoxyflavone (2). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information. The anti-microbial activities of extracts and three isolated compounds were performed. The antibacterial activity was evaluated against four gram positive, five gram negative and three fungus. Clerodendronone 1b (4) showed good antibacterial activity against bacterial gram negative Shigella flexineri NR518 (MIC = 62.5 μg/ml) and moderate activity against Staphylococcus aureus NR46374 (MIC = 250 μ/ml). The ethyl acetate extract recorded good antibacterial activity against Staphylococcus aureus NR46003 (MIC = 125 µg/ml) and Staphylococcus aureus NR46374 (MIC = 125 μg/ml).