A New Type of Human Papillomavirus Associated With Oral Focal Epithelial Hyperplasia

• Published in: Journal of investigative dermatology Vol. 88; no. 2; pp. 130 - 135
• Main Authors: Beaudenon, Sylvie, Praetorius, Finn, Kremsdorf, Dina, Lutzner, Marvin, Worsaae, Niels, Pehau-Arnaudet, Gérard, Orth, Gérard
• Format: Journal Article
• Language: English
• Published: Danvers, MA Elsevier Inc 01-02-1987; Nature Publishing
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Condylomata Acuminata - etiology; Condylomata Acuminata - microbiology; Dermatology; DNA, Viral - analysis; Female; Genomes; Human papillomavirus; Humans; Hyperplasia; Male; Medical sciences; Middle Aged; Mouth Mucosa - microbiology; Mouth Mucosa - pathology; Mouth Neoplasms - etiology; Mouth Neoplasms - microbiology; Mucosa; Neoplasms, Multiple Primary - etiology; Neoplasms, Multiple Primary - microbiology; Nucleotide sequence; Otorhinolaryngology. Stomatology; Papilloma; Papilloma - etiology; Papilloma - microbiology; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Penile Neoplasms - etiology; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Warts - complications; Warts - microbiology; Infection; Virus; Papillomavirus; Oral cavity; Skin disease; Epithelial hyperplasia focal; Viral disease; ENT disease; Papovaviridae
• ISSN: 0022-202X; 1523-1747
• DOI: 10.1111/1523-1747.ep12525278

Lesions from 10 patients suffering from focal epithelial hyperplasia (FEH) of the oral mucosa, including those of 4 Greenlandic Eskimos, were investigated for the presence of human papillomavirus (HPV) DNA sequences, by blot hybridization experiments. Two distinct HPVs were detected in the DNA extracted from these lesions, and their genomes were molecularly cloned and characterized. One of these HPVs, detected in 4 patients, were found to be identical with HPV13, whose association with FEH was already known. The other one detected in 6 patients was only weakly related to HPV13 and to the other HPVs associated with lesions of the mucous membranes, and constituted a new HPV type, tentatively named HPV32. Lesions from other types of oral papillomas, obtained from 14 additional patients, were also analyzed. Human papillomavirus DNA sequences were detected in the DNA preparations extracted from 5 specimens: HPV6 DNA a condyloma and in a papilloma, 2 as yet uncharacterized HPV DNAs in 2 papillomas, and HPV32 DNA in a papilloma which showed histologic similarities to FEH. Thus, it seems likely that FEH of the oral mucosa is a disease associated with 2 specific HPV-HPV13 and HPV32.