Effects of TAT-conjugated platinum nanoparticles on lifespan of mitochondrial electron transport complex I-deficient Caenorhabditis elegans, nuo-1

Platinum nanoparticle (Pt-np) species are superoxide dismutase/catalase mimetics and also have an activity similar to that of mitochondrial electron transport complex I. To examine if this complex I-like activity functions in vivo, we studied the effects of Pt-nps on the lifespan of a mitochondrial...

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Bibliographic Details
Published in:	International journal of nanomedicine Vol. 5; no. default; pp. 687 - 695
Main Authors:	Sakaue, Yuri, Kim, Juewon, Miyamoto, Yusei
Format:	Journal Article
Language:	English
Published:	New Zealand Taylor & Francis Ltd 01-01-2010 Dove Press Dove Medical Press
Subjects:	Amino Acid Substitution Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics complex I-deficient mutant Electron Transport Complex I - deficiency Electron Transport Complex I - genetics Genes, Helminth HIV-1 Humans LB25 lifespan Longevity - drug effects Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Mitochondria Mitochondria - metabolism Mutagenesis, Site-Directed NAD - metabolism Nanomedicine Nematodes Original Research Peptide Fragments - administration & dosage Peptides Platinum - administration & dosage platinum nanoparticles Reactive Oxygen Species - metabolism tat Gene Products, Human Immunodeficiency Virus - administration & dosage platinum nanoparticles Caenorhabditis elegans LB25 complex I-deficient mutant lifespan
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