Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis

Chemotherapy-induced mucositis is an important dose-limiting and costly side effect for which there is no definitive prophylaxis or treatment. This is due in part to the lack of understanding of its pathophysiology and impact on intestinal function. The objectives of this study were to investigate t...

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Bibliographic Details
Published in:	Digestive diseases and sciences Vol. 49; no. 1; pp. 65 - 72
Main Authors:	CARNEIRO-FILHO, B. A, LIMA, I. P. F, LIMA, A. A. M, ARAUJO, D. H, CAVALCANTE, M. C, CARVALHO, G. H. P, BRITO, G. A. C, LIMA, V, MONTEIRO, S. M. N, SANTOS, F. N, RIBEIRO, R. A
Format:	Journal Article
Language:	English
Published:	Heidelberg Springer 2004 Springer Nature B.V
Subjects:	Animals Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacology Biological and medical sciences Biological Transport - drug effects Disease Models, Animal Dose-Response Relationship, Drug Duodenum Eating Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Ileum Intestinal Absorption - drug effects Intestinal Mucosa Jejunum Male Medical sciences Metabolic diseases Methotrexate - administration & dosage Methotrexate - pharmacology Potassium - metabolism Rats Rats, Wistar Sodium - metabolism Stomatitis - chemically induced Stomatitis - physiopathology Vertebrates: anatomy and physiology, studies on body, several organs or systems Water - metabolism Weight Loss Nutrition Rat Barrier function Secretion Rodentia Gut Metabolic diseases Permeability mucositis Vertebrata Chemotherapy intestinal permeability Mammalia Treatment Animal Gastroenterology Methotrexate
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