Role of transforming growth factor-β superfamily signaling pathways in human disease
Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation, differentiation, migration, and survival, as well as physiological processes, including embryonic development, angiogenesis, and wound healing. A...
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| Published in: | Biochimica et biophysica acta Vol. 1782; no. 4; pp. 197 - 228 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Netherlands
Elsevier B.V
01-04-2008
Elsevier |
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| Abstract | Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation, differentiation, migration, and survival, as well as physiological processes, including embryonic development, angiogenesis, and wound healing. Alterations in these pathways, including either germ-line or somatic mutations or alterations in the expression of members of these signaling pathways often result in human disease. Appropriate regulation of these pathways is required at all levels, particularly at the ligand level, with either a deficiency or an excess of specific TGF-β superfamily ligands resulting in human disease. TGF-β superfamily ligands and members of these TGF-β superfamily signaling pathways also have emerging roles as diagnostic, prognostic or predictive markers for human disease. Ongoing studies will enable targeting of TGF-β superfamily signaling pathways for the chemoprevention and treatment of human disease. |
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| AbstractList | Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation, differentiation, migration, and survival, as well as physiological processes, including embryonic development, angiogenesis, and wound healing. Alterations in these pathways, including either germ-line or somatic mutations or alterations in the expression of members of these signaling pathways often result in human disease. Appropriate regulation of these pathways is required at all levels, particularly at the ligand level, with either a deficiency or an excess of specific TGF-β superfamily ligands resulting in human disease. TGF-β superfamily ligands and members of these TGF-β superfamily signaling pathways also have emerging roles as diagnostic, prognostic or predictive markers for human disease. Ongoing studies will enable targeting of TGF-β superfamily signaling pathways for the chemoprevention and treatment of human disease. Transforming growth factor beta (TGF-beta) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation, differentiation, migration, and survival, as well as physiological processes, including embryonic development, angiogenesis, and wound healing. Alterations in these pathways, including either germ-line or somatic mutations or alterations in the expression of members of these signaling pathways often result in human disease. Appropriate regulation of these pathways is required at all levels, particularly at the ligand level, with either a deficiency or an excess of specific TGF-beta superfamily ligands resulting in human disease. TGF-beta superfamily ligands and members of these TGF-beta superfamily signaling pathways also have emerging roles as diagnostic, prognostic or predictive markers for human disease. Ongoing studies will enable targeting of TGF-beta superfamily signaling pathways for the chemoprevention and treatment of human disease. |
| Author | Blobe, Gerard C. Gordon, Kelly J. |
| Author_xml | – sequence: 1 givenname: Kelly J. surname: Gordon fullname: Gordon, Kelly J. organization: Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA – sequence: 2 givenname: Gerard C. surname: Blobe fullname: Blobe, Gerard C. email: blobe001@mc.duke.edu organization: Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18313409$$D View this record in MEDLINE/PubMed https://hal.science/hal-00562819$$DView record in HAL |
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| Issue | 4 |
| Keywords | TGF-β superfamily Hereditary disease Sporadic disease Life Sciences |
| Language | English |
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| PublicationTitle | Biochimica et biophysica acta |
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| Snippet | Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including proliferation,... Transforming growth factor beta (TGF-beta) superfamily signaling pathways are ubiquitous and essential regulators of cellular processes including... |
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| SubjectTerms | Biomarkers Cardiovascular Diseases - genetics Chromosome Aberrations Disease Female Genetic Diseases, Inborn - genetics Hereditary disease Humans Ligands Musculoskeletal Diseases - genetics Mutation Neoplasms - genetics Pregnancy Pregnancy Complications - genetics Prognosis Signal Transduction Sporadic disease TGF-β superfamily Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology |
| Title | Role of transforming growth factor-β superfamily signaling pathways in human disease |
| URI | https://dx.doi.org/10.1016/j.bbadis.2008.01.006 https://www.ncbi.nlm.nih.gov/pubmed/18313409 https://hal.science/hal-00562819 |
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