Chronic copper toxicosis in sheep following the use of copper sulfate as a fungicide on fruit trees

• Published in: Journal of veterinary diagnostic investigation Vol. 21; no. 4; pp. 540 - 543
• Main Authors: Oruc, Hasan H, Cengiz, Murat, Beskaya, Atilla
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA J Vet Diagn Invest 01-07-2009; SAGE Publications
• Subjects: animal tissues; Animals; chronic toxicity; copper; Copper - blood; Copper - chemistry; copper sulfate; Copper Sulfate - chemistry; Copper Sulfate - toxicity; disease outbreaks; Environmental Pollutants - chemistry; Environmental Pollutants - toxicity; Female; fruit trees; fungicide residues; Fungicides, Industrial - toxicity; Kidney - chemistry; Liver - chemistry; Male; necropsy; Plants - chemistry; poisoning; Sheep; Sheep Diseases - chemically induced; Soil - analysis; tissue analysis; Trees; Water - chemistry; Turkey (country); Chronic copper toxicosis; vegetation; industrial contamination; fungicide; copper sulfate; sheep
• ISSN: 1040-6387; 1943-4936
• DOI: 10.1177/104063870902100420

Correspondence: 1 Corresponding Author: Hasan H. Oruc, Uludag Universitesi, Veteriner Fakultesi, Farmakoloji ve Toksikoloji A.D., 16059, Bursa, Turkey. oruc{at}uludag.edu.tr
Between January and October 2006, 15 Chios sheep died in a field located near a factory in Orhangazi, Bursa, Turkey. In addition, in May 2007, 2 ewes died after aborting in the same field. Clinical signs in affected animals prior to death were anorexia, hematuria, icterus, incoordination, and ptyalism. Postmortem findings included generalized icterus; yellow, friable livers; distended gallbladders with dense, dark bile; and dark, hypertrophic kidneys with hemorrhage. Copper (Cu) concentrations were measured in multiple specimens of the following: 9 sera, 3 livers, 3 kidneys, 4 plants (including 2 artichoke leaf specimens), 3 soil samples, and 1 drinking water sample. High Cu concentrations were present in the livers, kidneys, and sera of dead sheep, as well as in the vegetation and soil samples from the field. Chronic Cu toxicosis was confirmed as the cause of death attributed primarily to the use of copper sulfate as a fungicide for fruit trees within the field. In addition, factory dust containing Cu might have been an additional factor in the toxicosis.
Key Words: Chronic copper toxicosis • copper sulfate • fungicide • industrial contamination • sheep • vegetation