Bronchopulmonary dysplasia: how can we improve its outcomes?

• Published in: Clinical and experimental pediatrics Vol. 62; no. 10; pp. 367 - 373
• Main Author: Sung, Tae-Jung
• Format: Journal Article
• Language: English
• Published: Sŏul Clinical and Experimental Pediatics / Korean Pediatric Society 01-10-2019; Korean Pediatric Society; 대한소아청소년과학회
• Subjects: Amniotic fluid; Antibiotics; Bronchopulmonary dysplasia; Chronic lung disease; Inflammation; Lung diseases; Lung injury; Lungs; Multiple births; Newborn babies; Nosocomial infections; Pathophysiology; Premature birth; Premature infant; Prevention; Respiratory distress syndrome; Review; Steroids; Surfactants; Ventilators; 소아과학; Bronchopulmonary dysplasia; Inflammation; Premature infant; Chronic lung disease; Lung injury
• ISSN: 1738-1061; 2092-7258; 2713-4148
• DOI: 10.3345/kjp.2019.00178

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the pathogenesis of BPD. Hence, the definition of BPD has changed from “old” to “new.” In this review, we discuss the various definitions of BPD, risk factors from the prenatal to postnatal periods, management strategies by phase, and future directions for research.