A case of reversible hypoparathyroidism in a patient with Riedel's thyroiditis treated with glucocorticoids

• Published in: Clinical case reports Vol. 11; no. 3; pp. e7085 - n/a
• Main Authors: Salhi, Salma, Oueslati, Ibtissem, Ayari, Sabrina, Kamoun, Elyes, Yazidi, Meriem, Chihaoui, Melika
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-03-2023; John Wiley and Sons Inc; Wiley
• Subjects: Antibodies; Biopsy; Case Report; Dyspnea; glucocorticoids; Goiter; Hypocalcemia; hypoparathyroidism; Hypothyroidism; Neutrophils; Patients; Riedel's thyroiditis; Thyroid cancer; Tomography; Ultrasonic imaging; Riedel's thyroiditis; hypoparathyroidism; glucocorticoids; hypocalcemia
• ISSN: 2050-0904; 2050-0904
• DOI: 10.1002/ccr3.7085

A 48‐year‐old woman with a history of primary hypothyroidism, presented with compressive symptoms secondary to a rapid enlargement of a preexisting goiter. She had no clinical signs of hypocalcemia. Biological tests revealed hypoparathyroidism. Cervicothoracic computed tomography scan showed a heterogeneous compressive goiter. The patient was treated with levothyroxine, calcium, and alfacalcidol. A total thyroidectomy was not performed because of the hard adhesion to neighboring structures. Histopathological examination of the thyroid biopsy was consistent with the diagnosis of Riedel's thyroiditis (RT). The patient was treated with glucocorticoids. The outcome was marked by the resolution of compressive symptoms and the decrease of the thyroid gland volume. Serum calcium and parathyroid hormone levels reached normal ranges after the discontinuation of vitaminocalcic supplementation. Hypoparathyroidism may be clinically asymptomatic in a patient with RT as in our case. Early administration of glucocorticoids may be effective in reducing the fibrosclerotic process and lead to the recovery of parathyroid dysfunction.
Hypoparathyroidism secondary to Riedel's thyroiditis (RT) may be asymptomatic. Glucocorticoids may reverse the fibrosclerotic process and parathyroid dysfunction if introduced early in the disease.