Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: comparative study in normal, quaking and jimpy mice

• Published in: Journal of neuroscience research Vol. 5; no. 5; p. 387
• Main Authors: Dupouey, P, Lucas, C V, Gomes, D, Jacque, C
• Format: Journal Article
• Language: English
• Published: United States 1980
• Subjects: Animals; Astrocytes - metabolism; Brain - metabolism; Cytoskeleton - metabolism; Fluorescent Antibody Technique; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Jimpy; Mice, Quaking; Myelin Basic Protein - metabolism; Nerve Tissue Proteins - metabolism; Species Specificity; Spinal Cord - metabolism
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490050504

The topographical distribution of myelin basic protein (MBP) and of glial fibrillary acidic protein (GFA) have been compared in the CNS of 18-day-old normal, quaking, and jimpy mice using indirect immunofluorescence. Comparison was made in brain and spinal cord sections. MBP was strongly decreased in quaking and jimpy mice in all parts of the CNS. A pronounced gliosis was observed in jimpy mice with occurrence of numerous hypertrophied astrocytes. To a lesser extent, an astrocytic reaction was also observed in quaking CNS.