Prognostic Value of Programmed Cell Death-Ligand 1 Expression in Tumor-Infiltrating Lymphocytes and Viral Load in Peripheral Blood Mononuclear Cells for Epstein–Barr Virus–Positive Nasopharyngeal Carcinoma

Abstract Background Epstein–Barr virus (EBV) infection has a role in the development and progression of nasopharyngeal carcinoma (NPC); however, it is unclear whether EBV load correlates with tumor prognosis or the need for immunotherapy. This study evaluated whether the EBV DNA concentration in per...

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Bibliographic Details
Published in:	Clinical chemistry (Baltimore, Md.) Vol. 66; no. 9; pp. 1219 - 1227
Main Authors:	Hu, Bin, Sun, Ming, Wang, Zijin, Zheng, Yanping, Cai, Weifeng, Shi, Helen Hsiao-Hsing, Zhuang, Yanzhen, Lin, Qin
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-09-2020 American Association for Clinical Chemistry, Inc
Subjects:	Adolescent Adult Aged Apoptosis B cells B7-H1 Antigen - analysis Biomarkers, Tumor - analysis Blood Blood levels Cancer Carcinoma Cell death Deoxyribonucleic acid Development and progression DNA Epstein-Barr virus Ethylenediaminetetraacetic acid Female Gene expression Health aspects Herpesvirus 4, Human Humans Immunohistochemistry Immunotherapy Leukocytes (mononuclear) Leukocytes, Mononuclear - virology Lymphocytes Lymphocytes, Tumor-Infiltrating - virology Male Medical prognosis Medical research Medicine, Experimental Metastases Middle Aged Nasopharyngeal carcinoma Nasopharyngeal Carcinoma - diagnosis Nasopharyngeal Carcinoma - virology Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - virology Patients PD-L1 protein Peripheral blood mononuclear cells Prognosis Progression-Free Survival Risk groups Throat cancer Tumor-infiltrating lymphocytes Tumors Viral Load Viruses Young Adult China Nasopharyngeal carcinoma PD-L1 EBV DNA droplet digital PCR recurrence and metastasis TIL
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