An Interaction between Bcl-xL and the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+ Uptake

The role of the antiapoptotic protein Bcl-xL in regulating mitochondrial Ca2+ ([Ca2+]mito) handling was examined in wild-type (WT) and Bcl-xL knock-out (Bcl-xL-KO) mouse embryonic fibroblast cells. Inositol 1,4,5-trisphosphate-generating agonist evoked cytosolic Ca2+ transients that produced a large...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 288; no. 27; pp. 19870 - 19881
Main Authors:	Huang, Huiya, Hu, Xiangxin, Eno, Colins O., Zhao, Guoping, Li, Chi, White, Carl
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 05-07-2013 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Bcl-2 Proteins bcl-X Protein - genetics bcl-X Protein - metabolism Calcium - metabolism Calcium Signaling Cells, Cultured Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fibroblasts - cytology Fibroblasts - metabolism Imaging Mice Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membranes - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Biophysics Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Protein-Protein Interactions Voltage-dependent Anion Channel Voltage-Dependent Anion Channels - genetics Voltage-Dependent Anion Channels - metabolism Mitochondria Bcl-2 Proteins Voltage-dependent Anion Channel Imaging Calcium Signaling Protein-Protein Interactions
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