Metastatic cutaneous squamous cell carcinoma of the external ear: a high-risk cutaneous subsite

• Published in: Journal of laryngology and otology Vol. 124; no. 1; p. 26
• Main Authors: Turner, S J, Morgan, G J, Palme, C E, Veness, M J
• Format: Journal Article
• Language: English
• Published: England 01-01-2010
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - therapy; Ear Neoplasms - mortality; Ear Neoplasms - therapy; Female; Humans; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Male; Middle Aged; Neck Dissection; Neuroma, Acoustic - surgery; Parotid Neoplasms - mortality; Parotid Neoplasms - secondary; Parotid Neoplasms - therapy; Postoperative Complications - surgery
• ISSN: 1748-5460
• DOI: 10.1017/S0022215109991101

Patients with cutaneous squamous cell carcinoma of the external ear may develop metastatic spread to the nearby ipsilateral parotid and/or upper cervical lymph nodes. The literature suggests that the external ear is a high-risk subsite for such tumours, due to nodal metastasis and its associated morbidity and mortality.
Between 1980 and 2007, 43 patients with a diagnosis of metastatic cutaneous squamous cell carcinoma of the external ear were treated with surgery alone, surgery plus adjuvant radiotherapy, or radiotherapy alone.
Patients comprised 39 men and four women. Their median age at diagnosis was 72 years, with a median follow up of 35 months. The median size of the primary lesion was 21 mm, with a median thickness of 7 mm. Fifteen patients presented concurrently with nodal metastases. Thirty patients developed parotid metastases (with positive cervical nodes in six patients), while 13 developed cervical metastases only. Eight patients underwent surgery alone, 32 underwent surgery plus adjuvant radiotherapy, and three received radiotherapy alone. At the last follow up, 15 patients had relapsed and nine had died of their disease, with a median survival after relapse of 5.5 months.
Patients with metastatic cutaneous squamous cell carcinoma of the external ear have a relatively poor outcome, with a significant number of patients experiencing nodal relapse and death after treatment.