Assessment of acute toxicity and histopathology of the fungicide captan in rainbow trout

• Published in: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 64; no. 3; pp. 175 - 179
• Main Authors: Boran, Halis, Capkin, Erol, Altinok, Ilhan, Terzi, Ertugrul
• Format: Journal Article
• Language: English
• Published: Munich Elsevier GmbH 01-03-2012; Elsevier
• Subjects: acute toxicity; Acute toxicity test; Animals; Biological and medical sciences; Captan; Captan - toxicity; epithelial cells; epithelium; fish; Fungicides, Industrial - toxicity; Histopathology; hyperplasia; hypertrophy; inflammation; Investigative techniques, diagnostic techniques (general aspects); kidneys; lethal concentration 50; liver; Medical sciences; necrosis; Oncorhynchus mykiss; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Rainbow trout; spleen; Histopathology; Acute toxicity test; Rainbow trout; Captan; Anatomic pathology; Toxicity; Acute; Exploration
• ISSN: 0940-2993; 1618-1433
• DOI: 10.1016/j.etp.2010.08.003

Acute toxicity of the fungicide, captan, to juvenile rainbow trout was evaluated under static-renewal test condition. Actual concentrations of captan ranged from 0.05 to 1.00mg/L. The concentrations of captan that killed 50% of the rainbow trout (3.11±0.8g) within 24 (24h; LC50), 48, 72 and 96h were 0.57±0.09, 0.49±0.10, 0.44±0.11 and 0.38±0.13mg/L (95% confidence limits), respectively. None of the unexposed control fish died and the first fish died 6h after exposure to captan (≥0.65mg/L). Hypertrophy, separation of epithelium from lamellae, lamellar fusion, and epithelial cell necrosis were observed on captan exposed fish. Gills also had scattered areas of focal lamellar hyperplasia. Fish exposed to fungicide had inflammation and necrosis in liver, trunk kidney and spleen. In order, the most affected organs were gill, trunk kidney and liver.