Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog

The hallmark of type 1 diabetes is autoimmune destruction of the insulin-producing β-cells of the pancreatic islets. Autoimmune diabetes has been difficult to study or treat because it is not usually diagnosed until substantial β-cell loss has already occurred. Imaging agents that permit noninvasive...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 31; pp. 12815 - 12820
Main Authors:	Reiner, Thomas, Thurber, Greg, Gaglia, Jason, Vinegoni, Claudio, Liew, Chong Wee, Upadhyay, Rabi, Kohler, Rainer H., Li, Li, Kulkarni, Rohit N., Benoist, Christophe, Mathis, Diane, Weissleder, Ralph
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 02-08-2011 National Acad Sciences
Subjects:	3T3 cells Amino Acid Sequence Animals Average linear density Binding Sites - genetics Biological Sciences Cell Line, Tumor Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Fluorescence Fluorescent Dyes - chemistry Glucagon-Like Peptide-1 Receptor Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Histology Humans Imaging Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Islets of Langerhans Laparoscopy - instrumentation Laparoscopy - methods Lysine - chemistry Lysine - genetics Lysine - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Microscopy, Fluorescence Molecular Sequence Data NIH 3T3 Cells Pancreas Pancreas - metabolism Pancreas - pathology Peptides - chemistry Peptides - genetics Peptides - metabolism Receptors Receptors, Glucagon - genetics Receptors, Glucagon - metabolism Streptozocin - toxicity Type 1 diabetes mellitus Venoms - chemistry Venoms - genetics Venoms - metabolism
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