Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: the progenitor cell of the malignant clone?

A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal Hodgkin/Reed–Sternberg cells, but also in a fraction of morphologically normal cells. However, the phenotypic constitution of these genetically abnormal, m...

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Published in:	The Journal of pathology Vol. 189; no. 4; pp. 527 - 532
Main Authors:	Jansen, Maurice P. H. M., Hopman, Anton H. N., Bot, Fredrik J., Haesevoets, Annick, Stevens-Kroef, Marian J. P. L., Arends, Jan Willem, Jox, Andrea, Wolf, Jürgen, Ramaekers, Frans C. S., Schouten, Harry C.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-12-1999 Wiley
Subjects:	Adult Aged B cells B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences Chromosome Aberrations Genotype Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - immunology Hodgkin Disease - pathology Hodgkin's disease Humans Immunohistochemistry In Situ Hybridization Ki-1 Antigen Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Phenotype progenitor cell Reed-Sternberg Cells - immunology Reed-Sternberg Cells - pathology Chromosomal aberration Human Immunohistochemistry In situ Histiogenesis Hodgkin disease Malignant hemopathy B-Lymphocyte Hybridization Lymphoma Sternberg cell Pathology Lymphoproliferative syndrome Molecular biology Progenitor cell
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Abstract	A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal Hodgkin/Reed–Sternberg cells, but also in a fraction of morphologically normal cells. However, the phenotypic constitution of these genetically abnormal, morphologically normal cells and their relationship to the malignant Hodgkin/Reed–Sternberg cells could not be established in the earlier cases studied, because of the low frequency of these cells. The present study investigated two cases of classical Hodgkin's disease containing a relatively large population of such apparently normal cells with aberrant chromosome copy numbers. The phenotype and their position within the developmental route of the malignant compartment were examined by a combined in situ hybridization and immunocytochemistry approach. Numerical abnormalities for chromosome 1 in one case and for chromosomes X, Y, and 1 in the other case were observed not only in CD30‐positive Hodgkin/Reed–Sternberg cells, but also in CD30‐negative, morphologically normal cells. It was shown that these genetically aberrant cells expressed the B‐cell antigen CD19, thus confirming their B‐cell nature. These studies indicate a relationship between the genome aberrations in these genetically abnormal, morphologically normal B‐cells and the Hodgkin/Reed–Sternberg cells, suggesting that they are progenitor cells of the malignant cell fraction. Copyright © 1999 John Wiley & Sons, Ltd.
AbstractList	A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal Hodgkin/Reed-Sternberg cells, but also in a fraction of morphologically normal cells. However, the phenotypic constitution of these genetically abnormal, morphologically normal cells and their relationship to the malignant Hodgkin/Reed-Sternberg cells could not be established in the earlier cases studied, because of the low frequency of these cells. The present study investigated two cases of classical Hodgkin's disease containing a relatively large population of such apparently normal cells with aberrant chromosome copy numbers. The phenotype and their position within the developmental route of the malignant compartment were examined by a combined in situ hybridization and immunocytochemistry approach. Numerical abnormalities for chromosome 1 in one case and for chromosomes X, Y, and 1 in the other case were observed not only in CD30-positive Hodgkin/Reed-Sternberg cells, but also in CD30-negative, morphologically normal cells. It was shown that these genetically aberrant cells expressed the B-cell antigen CD19, thus confirming their B-cell nature. These studies indicate a relationship between the genome aberrations in these genetically abnormal, morphologically normal B-cells and the Hodgkin/Reed-Sternberg cells, suggesting that they are progenitor cells of the malignant cell fraction. A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal Hodgkin/Reed–Sternberg cells, but also in a fraction of morphologically normal cells. However, the phenotypic constitution of these genetically abnormal, morphologically normal cells and their relationship to the malignant Hodgkin/Reed–Sternberg cells could not be established in the earlier cases studied, because of the low frequency of these cells. The present study investigated two cases of classical Hodgkin's disease containing a relatively large population of such apparently normal cells with aberrant chromosome copy numbers. The phenotype and their position within the developmental route of the malignant compartment were examined by a combined in situ hybridization and immunocytochemistry approach. Numerical abnormalities for chromosome 1 in one case and for chromosomes X, Y, and 1 in the other case were observed not only in CD30‐positive Hodgkin/Reed–Sternberg cells, but also in CD30‐negative, morphologically normal cells. It was shown that these genetically aberrant cells expressed the B‐cell antigen CD19, thus confirming their B‐cell nature. These studies indicate a relationship between the genome aberrations in these genetically abnormal, morphologically normal B‐cells and the Hodgkin/Reed–Sternberg cells, suggesting that they are progenitor cells of the malignant cell fraction. Copyright © 1999 John Wiley & Sons, Ltd.
Author	Schouten, Harry C. Arends, Jan Willem Jansen, Maurice P. H. M. Haesevoets, Annick Stevens-Kroef, Marian J. P. L. Jox, Andrea Hopman, Anton H. N. Bot, Fredrik J. Wolf, Jürgen Ramaekers, Frans C. S.
Author_xml	– sequence: 1 givenname: Maurice P. H. M. surname: Jansen fullname: Jansen, Maurice P. H. M. organization: Department of Internal Medicine, University Hospital, Maastricht, The Netherlands – sequence: 2 givenname: Anton H. N. surname: Hopman fullname: Hopman, Anton H. N. organization: Department of Molecular Cell Biology and Genetics, University of Maastricht, The Netherlands – sequence: 3 givenname: Fredrik J. surname: Bot fullname: Bot, Fredrik J. organization: Department of Pathology, University Hospital Maastricht, The Netherlands – sequence: 4 givenname: Annick surname: Haesevoets fullname: Haesevoets, Annick organization: Department of Internal Medicine, University Hospital, Maastricht, The Netherlands – sequence: 5 givenname: Marian J. P. L. surname: Stevens-Kroef fullname: Stevens-Kroef, Marian J. P. L. organization: Department of Molecular Cell Biology and Genetics, University of Maastricht, The Netherlands – sequence: 6 givenname: Jan Willem surname: Arends fullname: Arends, Jan Willem organization: Department of Pathology, University Hospital Maastricht, The Netherlands – sequence: 7 givenname: Andrea surname: Jox fullname: Jox, Andrea organization: Department of Internal Medicine, University of Cologne, Germany – sequence: 8 givenname: Jürgen surname: Wolf fullname: Wolf, Jürgen organization: Department of Internal Medicine, University of Cologne, Germany – sequence: 9 givenname: Frans C. S. surname: Ramaekers fullname: Ramaekers, Frans C. S. organization: Department of Molecular Cell Biology and Genetics, University of Maastricht, The Netherlands – sequence: 10 givenname: Harry C. surname: Schouten fullname: Schouten, Harry C. email: hsch@sint.azm.nl organization: Department of Internal Medicine, University Hospital, Maastricht, The Netherlands
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Keywords	Chromosomal aberration Human Immunohistochemistry In situ Histiogenesis Hodgkin disease Malignant hemopathy B-Lymphocyte Hybridization Lymphoma Sternberg cell Pathology Lymphoproliferative syndrome Molecular biology Progenitor cell
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Snippet	A recent study observed that numerical chromosome abnormalities in Hodgkin's disease (HD) are detected not only in morphologically abnormal...
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SubjectTerms	Adult Aged B cells B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences Chromosome Aberrations Genotype Hematologic and hematopoietic diseases Hodgkin Disease - genetics Hodgkin Disease - immunology Hodgkin Disease - pathology Hodgkin's disease Humans Immunohistochemistry In Situ Hybridization Ki-1 Antigen Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Phenotype progenitor cell Reed-Sternberg Cells - immunology Reed-Sternberg Cells - pathology
Title	Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: the progenitor cell of the malignant clone?
URI	https://api.istex.fr/ark:/67375/WNG-JVCN44PD-J/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2F%28SICI%291096-9896%28199912%29189%3A4%3C527%3A%3AAID-PATH488%3E3.0.CO%3B2-N https://www.ncbi.nlm.nih.gov/pubmed/10629553 https://search.proquest.com/docview/69401374
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