Post-transcriptional regulation controlled by E-cadherin is important for c-Jun activity in melanoma
Summary A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is linked to the activation of the proto‐oncogene c‐Jun, a key player in tumorigenesis. In vivo, malignant melanomas show strong expression of the c...
Saved in:
| Published in: | Pigment cell and melanoma research Vol. 24; no. 1; pp. 148 - 164 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01-02-2011
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Summary
A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is linked to the activation of the proto‐oncogene c‐Jun, a key player in tumorigenesis. In vivo, malignant melanomas show strong expression of the c‐Jun protein in contrast to melanocytes. Interestingly, c‐Jun mRNA levels did not differ in the melanoma cell lines when compared to melanocytes, suggesting that c‐Jun could be regulated at the post‐transcriptional level. To uncover the link between E‐cadherin and c‐Jun, we re‐expressed E‐cadherin in melanoma cells and detected decreased protein expression and activity of c‐Jun. Furthermore, c‐Jun accumulation is dependent on active E‐cadherin‐mediated cell–cell adhesion and regulated via the cytoskeleton. Additionally, we determined that, with respect to c‐Jun regulation, there are two melanoma subgroups. One subgroup regulates c‐Jun expression via the newly discovered E‐cadherin‐dependent signaling pathway, whereas the other subgroup uses the MAPKinases to regulate its expression. In summary, our data provide novel insights into the tumor‐suppressor function of E‐cadherin, which contributes to the suppression of c‐Jun protein translation and transcriptional activity independent of MAPKinases. |
|---|---|
| AbstractList | A central event in the development of malignant melanoma is the loss of the tumor-suppressor protein E-cadherin. Here, we report that this loss is linked to the activation of the proto-oncogene c-Jun, a key player in tumorigenesis. In vivo, malignant melanomas show strong expression of the c-Jun protein in contrast to melanocytes. Interestingly, c-Jun mRNA levels did not differ in the melanoma cell lines when compared to melanocytes, suggesting that c-Jun could be regulated at the post-transcriptional level. To uncover the link between E-cadherin and c-Jun, we re-expressed E-cadherin in melanoma cells and detected decreased protein expression and activity of c-Jun. Furthermore, c-Jun accumulation is dependent on active E-cadherin-mediated cell-cell adhesion and regulated via the cytoskeleton. Additionally, we determined that, with respect to c-Jun regulation, there are two melanoma subgroups. One subgroup regulates c-Jun expression via the newly discovered E-cadherin-dependent signaling pathway, whereas the other subgroup uses the MAPKinases to regulate its expression. In summary, our data provide novel insights into the tumor-suppressor function of E-cadherin, which contributes to the suppression of c-Jun protein translation and transcriptional activity independent of MAPKinases. Summary A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is linked to the activation of the proto‐oncogene c‐Jun, a key player in tumorigenesis. In vivo, malignant melanomas show strong expression of the c‐Jun protein in contrast to melanocytes. Interestingly, c‐Jun mRNA levels did not differ in the melanoma cell lines when compared to melanocytes, suggesting that c‐Jun could be regulated at the post‐transcriptional level. To uncover the link between E‐cadherin and c‐Jun, we re‐expressed E‐cadherin in melanoma cells and detected decreased protein expression and activity of c‐Jun. Furthermore, c‐Jun accumulation is dependent on active E‐cadherin‐mediated cell–cell adhesion and regulated via the cytoskeleton. Additionally, we determined that, with respect to c‐Jun regulation, there are two melanoma subgroups. One subgroup regulates c‐Jun expression via the newly discovered E‐cadherin‐dependent signaling pathway, whereas the other subgroup uses the MAPKinases to regulate its expression. In summary, our data provide novel insights into the tumor‐suppressor function of E‐cadherin, which contributes to the suppression of c‐Jun protein translation and transcriptional activity independent of MAPKinases. Summary A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is linked to the activation of the proto‐oncogene c‐Jun, a key player in tumorigenesis. In vivo , malignant melanomas show strong expression of the c‐Jun protein in contrast to melanocytes. Interestingly, c‐Jun mRNA levels did not differ in the melanoma cell lines when compared to melanocytes, suggesting that c‐Jun could be regulated at the post‐transcriptional level. To uncover the link between E‐cadherin and c‐Jun, we re‐expressed E‐cadherin in melanoma cells and detected decreased protein expression and activity of c‐Jun. Furthermore, c‐Jun accumulation is dependent on active E‐cadherin‐mediated cell–cell adhesion and regulated via the cytoskeleton. Additionally, we determined that, with respect to c‐Jun regulation, there are two melanoma subgroups. One subgroup regulates c‐Jun expression via the newly discovered E‐cadherin‐dependent signaling pathway, whereas the other subgroup uses the MAPKinases to regulate its expression. In summary, our data provide novel insights into the tumor‐suppressor function of E‐cadherin, which contributes to the suppression of c‐Jun protein translation and transcriptional activity independent of MAPKinases. |
| Author | Vardimon, L. Spangler, B. Bosserhoff, A. K. Kuphal, S. |
| Author_xml | – sequence: 1 givenname: B. surname: Spangler fullname: Spangler, B. organization: Institute of Pathology, University of Regensburg, Regensburg, Germany – sequence: 2 givenname: L. surname: Vardimon fullname: Vardimon, L. organization: Department of Biochemistry, Tel Aviv University, Tel Aviv, Israel – sequence: 3 givenname: A. K. surname: Bosserhoff fullname: Bosserhoff, A. K. organization: Institute of Pathology, University of Regensburg, Regensburg, Germany – sequence: 4 givenname: S. surname: Kuphal fullname: Kuphal, S. organization: Institute of Pathology, University of Regensburg, Regensburg, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20977688$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkUuT1CAUhSlrLOehf8Fip5u0l5AEsnBhdc2Mj1HH8bmjaB5Km0ALRLv_vcQee2nJhnvhOxfqnFN05IM3CGECC1LWk_WCsLatSMO_LGoopwCMs8X2Djo5XBwdakaO0WlKa4AO2p7eQ8c19Ix1nJ8gfR1SrnKUPqnoNtkFLwcczddpkHODVfA5hmEwGq92-LxSUn8z0XnsEnbjJsQsfcY2RKyql5PHUmX30-UdLshoBunDKO-ju1YOyTy43c_Qx4vzD8vn1dXbyxfLZ1eVamjPKg7AqW1sQ-xKkx4oVRaglh1vTU9WtQXdawtW1Ro6Q3XLDZfAVW-bhskO6Bl6tJ-7ieHHZFIWo0vKDOUXJkxJ8AZoC5TQQj7-J0mg5lDcgxnle1TFkFI0VmyiG2XcFUjMaYi1mI0Ws-liTkP8SUNsi_Th7SvTajT6IPxrfwGe7oFfbjC7_x4srpevb0pV9NVe71I224Nexu-iY5S14vObS_Hpgt28X77i4h39DbJvqtc |
| CitedBy_id | crossref_primary_10_1038_onc_2017_135 crossref_primary_10_1038_s41419_019_1821_9 crossref_primary_10_1080_15384047_2016_1156264 crossref_primary_10_1016_j_abb_2011_10_020 crossref_primary_10_1128_MCB_06619_11 crossref_primary_10_1038_celldisc_2016_28 crossref_primary_10_1002_ar_23992 crossref_primary_10_1016_j_cellsig_2021_110034 crossref_primary_10_1371_journal_pone_0119402 crossref_primary_10_1038_labinvest_2014_3 crossref_primary_10_18632_oncotarget_2426 crossref_primary_10_3390_cancers11071037 crossref_primary_10_3389_fonc_2016_00128 crossref_primary_10_1158_0008_5472_CAN_19_0040 crossref_primary_10_1083_jcb_201612125 crossref_primary_10_18632_oncotarget_26508 crossref_primary_10_1016_j_it_2016_03_009 crossref_primary_10_1038_s41418_018_0210_8 crossref_primary_10_1038_ncomms9755 crossref_primary_10_1038_onc_2012_307 crossref_primary_10_1016_j_ejcb_2013_10_003 crossref_primary_10_1073_pnas_1203659109 crossref_primary_10_1126_scisignal_aab1111 crossref_primary_10_1371_journal_pone_0089491 crossref_primary_10_1007_s12253_017_0334_z |
| Cites_doi | 10.1038/79120 10.1016/j.molcel.2005.06.025 10.1111/j.1742-4658.2008.06349.x 10.1097/00008390-199806000-00003 10.1002/jcp.10008 10.1128/MCB.11.5.2804 10.1023/A:1015948505117 10.1038/sj.onc.1200991 10.1016/S0092-8674(00)00193-8 10.1007/BF00054016 10.1073/pnas.87.11.4246 10.1016/j.ccr.2007.03.009 10.1136/mp.50.6.289 10.1038/sj.onc.1207797 10.1016/0092-8674(95)90370-4 10.1038/nrc1209 10.1016/S1097-2765(04)00153-4 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K 10.1038/371171a0 10.1002/j.1460-2075.1995.tb00301.x 10.1016/S0092-8674(05)80058-3 10.1073/pnas.91.2.609 10.4161/cc.3.2.648 10.1083/jcb.130.1.67 10.1002/mc.2940100205 10.1128/MCB.20.10.3616-3625.2000 10.1083/jcb.116.4.989 10.1038/sj.onc.1209114 10.1128/MCB.11.9.4466 10.1091/mbc.E08-12-1196 10.1038/sj.onc.1209054 10.1084/jem.20082044 10.1038/354494a0 10.1038/sj.onc.1207831 10.1038/sj.onc.1204383 10.1083/jcb.106.3.761 10.1074/jbc.270.28.16483 10.3109/15419069409014207 10.1073/pnas.85.22.8464 10.4161/cc.2.3.388 10.1128/MCB.20.2.575-582.2000 10.1126/science.2541502 10.1158/0008-5472.CAN-07-2938 10.1002/(SICI)1096-9896(199812)186:4<350::AID-PATH181>3.0.CO;2-K 10.1016/S0002-9440(10)65023-7 10.1038/32918 10.1126/science.7824938 10.1034/j.1600-0625.2003.120310.x 10.1136/mp.52.3.151 10.1016/S1534-5807(03)00161-8 10.1074/jbc.M011224200 10.1158/0008-5472.CAN-08-0041 10.1038/sj.onc.1204389 10.1038/353670a0 10.1128/MCB.25.20.9138-9150.2005 10.1038/337661a0 |
| ContentType | Journal Article |
| Copyright | 2010 John Wiley & Sons A/S 2010 John Wiley & Sons A/S. |
| Copyright_xml | – notice: 2010 John Wiley & Sons A/S – notice: 2010 John Wiley & Sons A/S. |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 7X8 |
| DOI | 10.1111/j.1755-148X.2010.00787.x |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Nucleic Acids Abstracts MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Zoology |
| EISSN | 1755-148X |
| EndPage | 164 |
| ExternalDocumentID | 10_1111_j_1755_148X_2010_00787_x 20977688 PCMR787 ark_67375_WNG_VF7RSCK8_Q |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1OC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5HH 5LA 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EAD EAP EBC EBD EBS EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HGLYW HVGLF HZ~ IHE IX1 J0M KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K ROL RX1 SUPJJ SV3 TEORI TUS UB1 W8V W99 WBKPD WIH WIJ WIK WNSPC WOHZO WOW WQJ WRC WXI WXSBR WYISQ XG1 ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 7X8 |
| ID | FETCH-LOGICAL-c4397-80083f4f41fbd19033cf002a685e91b2f0d9df0fc2d06e3d58e8a08c9f447a603 |
| IEDL.DBID | 33P |
| ISSN | 1755-1471 |
| IngestDate | Fri Aug 16 21:27:55 EDT 2024 Fri Aug 16 11:58:23 EDT 2024 Fri Aug 23 01:51:38 EDT 2024 Sat Sep 28 07:58:56 EDT 2024 Sat Aug 24 00:48:49 EDT 2024 Wed Oct 30 09:55:44 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2010 John Wiley & Sons A/S. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4397-80083f4f41fbd19033cf002a685e91b2f0d9df0fc2d06e3d58e8a08c9f447a603 |
| Notes | istex:D0C7BDFD7E5E96A7D9275FDF3D928C9F5CF700B0 ark:/67375/WNG-VF7RSCK8-Q ArticleID:PCMR787 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| PMID | 20977688 |
| PQID | 1028075503 |
| PQPubID | 23462 |
| PageCount | 17 |
| ParticipantIDs | proquest_miscellaneous_840350313 proquest_miscellaneous_1028075503 crossref_primary_10_1111_j_1755_148X_2010_00787_x pubmed_primary_20977688 wiley_primary_10_1111_j_1755_148X_2010_00787_x_PCMR787 istex_primary_ark_67375_WNG_VF7RSCK8_Q |
| PublicationCentury | 2000 |
| PublicationDate | 2011-02 February 2011 2011-Feb 2011-02-00 20110201 |
| PublicationDateYYYYMMDD | 2011-02-01 |
| PublicationDate_xml | – month: 02 year: 2011 text: 2011-02 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England |
| PublicationTitle | Pigment cell and melanoma research |
| PublicationTitleAlternate | Pigment Cell Melanoma Res |
| PublicationYear | 2011 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Stappert, J., and Kemler, R. (1994). A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated. Cell Adhes. Commun. 2, 319-327. Brenner, D.A., O'Hara, M., Angel, P., Chojkier, M., and Karin, M. (1989). Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 337, 661-663. Hsu, M.Y., Meier, F.E., Nesbit, M., Hsu, J.Y., Van Belle, P., Elder, D.E., and Herlyn, M. (2000). E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am. J. Pathol. 156, 1515-1525. Poser, I., Tatzel, J., Kuphal, S., and Bosserhoff, A.K. (2004). Functional role of MIA in melanocytes and early development of melanoma. Oncogene 23, 6115-6124. Bernstein, L.R., and Colburn, N.H. (1989). AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science 244, 566-569. Boukamp, P., Dzarlieva-Petrusevska, R.T., Breitkreuz, D., Hornung, J., Markham, A., and Fusenig, N.E. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771. Blattner, C., Kannouche, P., Litfin, M., Bender, K., Rahmsdorf, H.J., Angulo, J.F., and Herrlich, P. (2000). UV-Induced stabilization of c-fos and other short-lived mRNAs. Mol. Cell. Biol. 20, 3616-3625. Nobes, C.D., and Hall, A. (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62. Sommers, C.L., Gelmann, E.P., Kemler, R., Cowin, P., and Byers, S.W. (1994). Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res. 54, 3544-3552. Wenke, A.K., Kjellman, C., Lundgren-Akerlund, E., Uhlmann, C., Haass, N.K., Herlyn, M., and Bosserhoff, A.K. (2007). Expression of integrin alpha10 is induced in malignant melanoma. Cell. Oncol. 29, 373-386. Berx, G., Cleton-Jansen, A.M., Nollet, F., de Leeuw, W.J., van de Vijver, M., Cornelisse, C., and van Roy, F. (1995). E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J. 14, 6107-6115. Onder, T.T., Gupta, P.B., Mani, S.A., Yang, J., Lander, E.S., and Weinberg, R.A. (2008). Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68, 3645-3654. Silye, R., Karayiannakis, A.J., Syrigos, K.N. et al. (1998). E-cadherin/catenin complex in benign and malignant melanocytic lesions. J. Pathol. 186, 350-355. Ozawa, M., and Kemler, R. (1992). Molecular organization of the uvomorulin-catenin complex. J. Cell Biol. 116, 989-996. Deng, T., and Karin, M. (1994). c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature 371, 171-175. Kennedy, N.J., and Davis, R.J. (2003). Role of JNK in tumor development. Cell Cycle 2, 199-201. Xiao, L., and Lang, W. (2000). A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells. Cancer Res. 60, 400-408. Halaban, R., Kwon, B.S., Ghosh, S., Delli, B.P., and Baird, A. (1988). bFGF as an autocrine growth factor for human melanomas. Oncogene Res. 3, 177-186. Kuphal, S., Poser, I., Jobin, C., Hellerbrand, C., and Bosserhoff, A.K. (2004). Loss of E-cadherin leads to upregulation of NFkappaB activity in malignant melanoma. Oncogene 23, 8509-8519. Ryder, K., and Nathans, D. (1988). Induction of protooncogene c-jun by serum growth factors. Proc. Natl. Acad. Sci. USA 85, 8464-8467. Hendrix, M.J., Seftor, E.A., Chu, Y.W., Trevor, K.T., and Seftor, R.E. (1996). Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev. 15, 507-525. Weiss, C., and Bohmann, D. (2004). Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis. Cell Cycle 3, 111-113. Knudsen, K.A., Soler, A.P., Johnson, K.R., and Wheelock, M.J. (1995). Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J. Cell Biol. 130, 67-77. Karin, M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270, 16483-16486. Lopez-Bergami, P., Habelhah, H., Bhoumik, A., Zhang, W., Wang, L.H., and Ronai, Z. (2005). RACK1 mediates activation of JNK by protein kinase C. Mol. Cell 19, 309-320. Rimm, D.L., Sinard, J.H., and Morrow, J.S. (1995). Reduced alpha-catenin and E-cadherin expression in breast cancer. Lab. Invest. 72, 506-512. Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A., and Reeve, A.E. (1998). E-cadherin germline mutations in familial gastric cancer. Nature 392, 402-405. Furukawa, F., Fujii, K., Horiguchi, Y., Matsuyoshi, N., Fujita, M., Toda, K., Imamura, S., Wakita, H., Shirahama, S., and Takigawa, M. (1997). Roles of E- and P-cadherin in the human skin. Microsc. Res. Tech. 38, 343-352. Kolbus, A., Herr, I., Schreiber, M., Debatin, K.M., Wagner, E.F., and Angel, P. (2000). c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol. Cell. Biol. 20, 575-582. Massoumi, R., Kuphal, S., Hellerbrand, C., Haas, B., Wild, P., Spruss, T., Pfeifer, A., Fassler, R., and Bosserhoff, A.K. (2009). Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J. Exp. Med. 206, 221-232. Rutberg, S.E., Goldstein, I.M., Yang, Y.M., Stackpole, C.W., and Ronai, Z. (1994). Expression and transcriptional activity of AP-1, CRE, and URE binding proteins in B16 mouse melanoma subclones. Mol. Carcinog. 10, 82-87. Zenz, R., Scheuch, H., Martin, P., Frank, C., Eferl, R., Kenner, L., Sibilia, M., and Wagner, E.F. (2003). c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4, 879-889. Meier, F., Caroli, U., Satyamoorthy, K. et al. (2003). Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma. Exp. Dermatol. 12, 296-306. Pla, P., Moore, R., Morali, O.G., Grille, S., Martinozzi, S., Delmas, V., and Larue, L. (2001). Cadherins in neural crest cell development and transformation. J. Cell. Physiol. 189, 121-132. Andersen, H., Mejlvang, J., Mahmood, S., Gromova, I., Gromov, P., Lukanidin, E., Kriajevska, M., Mellon, J.K., and Tulchinsky, E. (2005). Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells. Mol. Cell. Biol. 25, 9138-9150. Lopez-Bergami, P., Huang, C., Goydos, J.S. et al. (2007). Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell 11, 447-460. Sanders, D.S., Blessing, K., Hassan, G.A., Bruton, R., Marsden, J.R., and Jankowski, J. (1999). Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours. Mol. Pathol. 52, 151-157. Bowden, G.T., Schneider, B., Domann, R., and Kulesz-Martin, M. (1994). Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis. Cancer Res. 54, 1882s-1885s. Cruz-Munoz, W., Man, S., Xu, P., and Kerbel, R.S. (2008). Development of a preclinical model of spontaneous human melanoma central nervous system metastasis. Cancer Res. 68, 4500-4505. Devary, Y., Gottlieb, R.A., Smeal, T., and Karin, M. (1992). The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71, 1081-1091. Dhar, A., Young, M.R., and Colburn, N.H. (2002). The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Mol. Cell. Biochem. 234-235, 185-193. Jankowski, J.A., Bruton, R., Shepherd, N., and Sanders, D.S. (1997). Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. Mol. Pathol. 50, 289-290. Poser, I., Dominguez, D., de Herreros, A.G., Varnai, A., Buettner, R., and Bosserhoff, A.K. (2001). Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J. Biol. Chem. 276, 24661-24666. Hsu, M.Y., Wheelock, M.J., Johnson, K.R., and Herlyn, M. (1996). Shifts in cadherin profiles between human normal melanocytes and melanomas. J. Investig. Dermatol. Symp. Proc. 1, 188-194. Jochum, W., Passegue, E., and Wagner, E.F. (2001). AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401-2412. Gupta, S., Campbell, D., Derijard, B., and Davis, R.J. (1995). Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393. Kovary, K., and Bravo, R. (1991). The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol. Cell. Biol. 11, 4466-4472. Mils, V., Piette, J., Barette, C., Veyrune, J., Tesniere, A., Escot, C., Guilhou, J.J., and Basset-Seguin, N. (1997). The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis. Oncogene 14, 1555-1561. Devary, Y., Gottlieb, R.A., Lau, L.F., and Karin, M. (1991). Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11, 2804-2811. Shaulian, E., Schreiber, M., Piu, F., Beeche, M., Wagner, E.F., and Karin, M. (2000). The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103, 897-907. Jacob, K., Wach, F., Holzapfel, U., Hein, R., Lengyel, E., Buettner, R., and Bosserhoff, A.K. (1998). In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid. Melanoma Res. 8, 211-219. Dong, Z., Birrer, M.J., Watts, R.G., Matrisian, L.M., and Colburn, N.H. (1994). Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc. Natl. Acad. Sci. USA 91, 609-613. Kolomeichuk, S.N., Terrano, D.T., Lyle, C.S., Sabapathy, K., and Chambers, T.C. (2008). Distinct signaling pathways of microtubule inhibitors - vinblastine and Taxol induce JNK-dependent cell death but through 2001; 189 1995; 72 1991; 354 1991; 353 1991; 11 2004; 23 1994; 371 2004; 3 1995; 130 1988; 106 1998; 392 2005; 25 2003; 12 2007; 29 1990; 87 1997; 50 1997; 14 2006; 25 2003; 2 1992; 116 2003; 3 2003; 4 2008; 68 2000; 60 1996; 1 1999; 52 1988; 85 2009; 206 2008; 275 1989; 337 2009; 20 2000; 26 1995; 14 2000; 20 2000; 156 2007; 11 1996; 15 1992; 71 1995; 270 2001; 20 2001; 276 1988; 3 2005; 19 1995; 81 1989; 244 2004; 19 2000; 103 2004; 14 1997; 38 2002; 234–235 1995; 267 1994; 91 1994; 2 1994; 54 1994; 10 1998; 186 1998; 8 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_3_1 e_1_2_8_5_1 e_1_2_8_9_1 e_1_2_8_43_1 Wenke A.K. (e_1_2_8_63_1) 2007; 29 e_1_2_8_45_1 Poser I. (e_1_2_8_48_1) 2004; 19 e_1_2_8_62_1 e_1_2_8_41_1 e_1_2_8_17_1 Hsu M.Y. (e_1_2_8_22_1) 1996; 1 e_1_2_8_19_1 Sommers C.L. (e_1_2_8_60_1) 1994; 54 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_59_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_57_1 Halaban R. (e_1_2_8_20_1) 1988; 3 e_1_2_8_32_1 e_1_2_8_55_1 Xiao L. (e_1_2_8_64_1) 2000; 60 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_51_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 Bowden G.T. (e_1_2_8_7_1) 1994; 54 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_65_1 e_1_2_8_40_1 e_1_2_8_61_1 e_1_2_8_18_1 e_1_2_8_39_1 Rimm D.L. (e_1_2_8_52_1) 1995; 72 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_58_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_56_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_54_1 e_1_2_8_50_1 |
| References_xml | – volume: 23 start-page: 6115 year: 2004 end-page: 6124 article-title: Functional role of MIA in melanocytes and early development of melanoma publication-title: Oncogene – volume: 11 start-page: 4466 year: 1991 end-page: 4472 article-title: The jun and fos protein families are both required for cell cycle progression in fibroblasts publication-title: Mol. Cell. Biol. – volume: 244 start-page: 566 year: 1989 end-page: 569 article-title: AP1/jun function is differentially induced in promotion‐sensitive and resistant JB6 cells publication-title: Science – volume: 189 start-page: 121 year: 2001 end-page: 132 article-title: Cadherins in neural crest cell development and transformation publication-title: J. Cell. Physiol. – volume: 19 start-page: 173 year: 2004 end-page: 188 article-title: Transcription factors involved in development and progression of malignant melanoma publication-title: Histol. Histopathol. – volume: 25 start-page: 9138 year: 2005 end-page: 9150 article-title: Immediate and delayed effects of E‐cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells publication-title: Mol. Cell. Biol. – volume: 26 start-page: 16 year: 2000 end-page: 17 article-title: Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer publication-title: Nat. Genet. – volume: 14 start-page: 1555 year: 1997 end-page: 1561 article-title: The proto‐oncogene c‐fos increases the sensitivity of keratinocytes to apoptosis publication-title: Oncogene – volume: 116 start-page: 989 year: 1992 end-page: 996 article-title: Molecular organization of the uvomorulin‐catenin complex publication-title: J. Cell Biol. – volume: 68 start-page: 4500 year: 2008 end-page: 4505 article-title: Development of a preclinical model of spontaneous human melanoma central nervous system metastasis publication-title: Cancer Res. – volume: 12 start-page: 296 year: 2003 end-page: 306 article-title: Fibroblast growth factor‐2 but not Mel‐CAM and/or beta3 integrin promotes progression of melanocytes to melanoma publication-title: Exp. Dermatol. – volume: 20 start-page: 2390 year: 2001 end-page: 2400 article-title: AP‐1 in cell proliferation and survival publication-title: Oncogene – volume: 38 start-page: 343 year: 1997 end-page: 352 article-title: Roles of E‐ and P‐cadherin in the human skin publication-title: Microsc. Res. Tech. – volume: 29 start-page: 373 year: 2007 end-page: 386 article-title: Expression of integrin alpha10 is induced in malignant melanoma publication-title: Cell. Oncol. – volume: 14 start-page: 29 year: 2004 end-page: 41 article-title: The small GTP‐binding protein RhoA regulates c‐jun by a ROCK‐JNK signaling axis publication-title: Mol. Cell – volume: 276 start-page: 24661 year: 2001 end-page: 24666 article-title: Loss of E‐cadherin expression in melanoma cells involves up‐regulation of the transcriptional repressor Snail publication-title: J. Biol. Chem. – volume: 234–235 start-page: 185 year: 2002 end-page: 193 article-title: The role of AP‐1, NF‐kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive publication-title: Mol. Cell. Biochem. – volume: 337 start-page: 661 year: 1989 end-page: 663 article-title: Prolonged activation of jun and collagenase genes by tumour necrosis factor‐alpha publication-title: Nature – volume: 371 start-page: 171 year: 1994 end-page: 175 article-title: c‐Fos transcriptional activity stimulated by H‐Ras‐activated protein kinase distinct from JNK and ERK publication-title: Nature – volume: 2 start-page: 199 year: 2003 end-page: 201 article-title: Role of JNK in tumor development publication-title: Cell Cycle – volume: 106 start-page: 761 year: 1988 end-page: 771 article-title: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line publication-title: J. Cell Biol. – volume: 353 start-page: 670 year: 1991 end-page: 674 article-title: Phosphorylation of c‐jun mediated by MAP kinases publication-title: Nature – volume: 275 start-page: 1889 year: 2008 end-page: 1899 article-title: Distinct signaling pathways of microtubule inhibitors – vinblastine and Taxol induce JNK‐dependent cell death but through AP‐1‐dependent and AP‐1‐independent mechanisms, respectively publication-title: FEBS J. – volume: 156 start-page: 1515 year: 2000 end-page: 1525 article-title: E‐cadherin expression in melanoma cells restores keratinocyte‐mediated growth control and down‐regulates expression of invasion‐related adhesion receptors publication-title: Am. J. Pathol. – volume: 60 start-page: 400 year: 2000 end-page: 408 article-title: A dominant role for the c‐Jun NH2‐terminal kinase in oncogenic ras‐induced morphologic transformation of human lung carcinoma cells publication-title: Cancer Res. – volume: 20 start-page: 575 year: 2000 end-page: 582 article-title: c‐Jun‐dependent CD95‐L expression is a rate‐limiting step in the induction of apoptosis by alkylating agents publication-title: Mol. Cell. Biol. – volume: 72 start-page: 506 year: 1995 end-page: 512 article-title: Reduced alpha‐catenin and E‐cadherin expression in breast cancer publication-title: Lab. Invest. – volume: 103 start-page: 897 year: 2000 end-page: 907 article-title: The mammalian UV response: c‐Jun induction is required for exit from p53‐imposed growth arrest publication-title: Cell – volume: 11 start-page: 447 year: 2007 end-page: 460 article-title: Rewired ERK‐JNK signaling pathways in melanoma publication-title: Cancer Cell – volume: 52 start-page: 151 year: 1999 end-page: 157 article-title: Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours publication-title: Mol. Pathol. – volume: 206 start-page: 221 year: 2009 end-page: 232 article-title: Down‐regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma publication-title: J. Exp. Med. – volume: 68 start-page: 3645 year: 2008 end-page: 3654 article-title: Loss of E‐cadherin promotes metastasis via multiple downstream transcriptional pathways publication-title: Cancer Res. – volume: 267 start-page: 389 year: 1995 end-page: 393 article-title: Transcription factor ATF2 regulation by the JNK signal transduction pathway publication-title: Science – volume: 19 start-page: 309 year: 2005 end-page: 320 article-title: RACK1 mediates activation of JNK by protein kinase C publication-title: Mol. Cell – volume: 91 start-page: 609 year: 1994 end-page: 613 article-title: Blocking of tumor promoter‐induced AP‐1 activity inhibits induced transformation in JB6 mouse epidermal cells publication-title: Proc. Natl. Acad. Sci. USA – volume: 14 start-page: 6107 year: 1995 end-page: 6115 article-title: E‐cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers publication-title: EMBO J. – volume: 23 start-page: 8509 year: 2004 end-page: 8519 article-title: Loss of E‐cadherin leads to upregulation of NFkappaB activity in malignant melanoma publication-title: Oncogene – volume: 20 start-page: 2401 year: 2001 end-page: 2412 article-title: AP‐1 in mouse development and tumorigenesis publication-title: Oncogene – volume: 186 start-page: 350 year: 1998 end-page: 355 article-title: E‐cadherin/catenin complex in benign and malignant melanocytic lesions publication-title: J. Pathol. – volume: 50 start-page: 289 year: 1997 end-page: 290 article-title: Cadherin and catenin biology represent a global mechanism for epithelial cancer progression publication-title: Mol. Pathol. – volume: 10 start-page: 82 year: 1994 end-page: 87 article-title: Expression and transcriptional activity of AP‐1, CRE, and URE binding proteins in B16 mouse melanoma subclones publication-title: Mol. Carcinog. – volume: 270 start-page: 16483 year: 1995 end-page: 16486 article-title: The regulation of AP‐1 activity by mitogen‐activated protein kinases publication-title: J. Biol. Chem. – volume: 3 start-page: 859 year: 2003 end-page: 868 article-title: AP‐1: a double‐edged sword in tumorigenesis publication-title: Nat. Rev. Cancer – volume: 8 start-page: 211 year: 1998 end-page: 219 article-title: In vitro modulation of human melanoma cell invasion and proliferation by all‐trans‐retinoic acid publication-title: Melanoma Res. – volume: 25 start-page: 248 year: 2006 end-page: 259 article-title: Influence of the cytoplasmic domain of E‐cadherin on endogenous N‐cadherin expression in malignant melanoma publication-title: Oncogene – volume: 2 start-page: 319 year: 1994 end-page: 327 article-title: A short core region of E‐cadherin is essential for catenin binding and is highly phosphorylated publication-title: Cell Adhes. Commun. – volume: 11 start-page: 2804 year: 1991 end-page: 2811 article-title: Rapid and preferential activation of the c‐jun gene during the mammalian UV response publication-title: Mol. Cell. Biol. – volume: 25 start-page: 665 year: 2006 end-page: 676 article-title: The cytoskeletal network controls c‐Jun translation in a UTR‐dependent manner publication-title: Oncogene – volume: 20 start-page: 3616 year: 2000 end-page: 3625 article-title: UV‐Induced stabilization of c‐fos and other short‐lived mRNAs publication-title: Mol. Cell. Biol. – volume: 1 start-page: 188 year: 1996 end-page: 194 article-title: Shifts in cadherin profiles between human normal melanocytes and melanomas publication-title: J. Investig. Dermatol. Symp. Proc. – volume: 20 start-page: 2121 year: 2009 end-page: 9 article-title: Loss of E‐cadherin mediated cell–cell contacts activates a novel mechanism for upregulation of the proto‐oncogene c‐Jun publication-title: Mol. Biol. Cell. – volume: 85 start-page: 8464 year: 1988 end-page: 8467 article-title: Induction of protooncogene c‐jun by serum growth factors publication-title: Proc. Natl. Acad. Sci. USA – volume: 54 start-page: 3544 year: 1994 end-page: 3552 article-title: Alterations in beta‐catenin phosphorylation and plakoglobin expression in human breast cancer cells publication-title: Cancer Res. – volume: 54 start-page: 1882s year: 1994 end-page: 1885s article-title: Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis publication-title: Cancer Res. – volume: 3 start-page: 177 year: 1988 end-page: 186 article-title: bFGF as an autocrine growth factor for human melanomas publication-title: Oncogene Res. – volume: 15 start-page: 507 year: 1996 end-page: 525 article-title: Role of intermediate filaments in migration, invasion and metastasis publication-title: Cancer Metastasis Rev. – volume: 81 start-page: 53 year: 1995 end-page: 62 article-title: Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia publication-title: Cell – volume: 3 start-page: 111 year: 2004 end-page: 113 article-title: Deregulated repression of c‐Jun provides a potential link to its role in tumorigenesis publication-title: Cell Cycle – volume: 71 start-page: 1081 year: 1992 end-page: 1091 article-title: The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases publication-title: Cell – volume: 392 start-page: 402 year: 1998 end-page: 405 article-title: E‐cadherin germline mutations in familial gastric cancer publication-title: Nature – volume: 4 start-page: 879 year: 2003 end-page: 889 article-title: c‐Jun regulates eyelid closure and skin tumor development through EGFR signaling publication-title: Dev. Cell – volume: 87 start-page: 4246 year: 1990 end-page: 4250 article-title: Uvomorulin‐catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule publication-title: Proc. Natl. Acad. Sci. USA – volume: 354 start-page: 494 year: 1991 end-page: 496 article-title: Oncogenic and transcriptional cooperation with Ha‐Ras requires phosphorylation of c‐Jun on serines 63 and 73 publication-title: Nature – volume: 130 start-page: 67 year: 1995 end-page: 77 article-title: Interaction of alpha‐actinin with the cadherin/catenin cell–cell adhesion complex via alpha‐catenin publication-title: J. Cell Biol. – ident: e_1_2_8_17_1 doi: 10.1038/79120 – ident: e_1_2_8_36_1 doi: 10.1016/j.molcel.2005.06.025 – volume: 54 start-page: 3544 year: 1994 ident: e_1_2_8_60_1 article-title: Alterations in beta‐catenin phosphorylation and plakoglobin expression in human breast cancer cells publication-title: Cancer Res. contributor: fullname: Sommers C.L. – ident: e_1_2_8_32_1 doi: 10.1111/j.1742-4658.2008.06349.x – ident: e_1_2_8_24_1 doi: 10.1097/00008390-199806000-00003 – ident: e_1_2_8_46_1 doi: 10.1002/jcp.10008 – ident: e_1_2_8_11_1 doi: 10.1128/MCB.11.5.2804 – ident: e_1_2_8_13_1 doi: 10.1023/A:1015948505117 – ident: e_1_2_8_41_1 doi: 10.1038/sj.onc.1200991 – ident: e_1_2_8_57_1 doi: 10.1016/S0092-8674(00)00193-8 – ident: e_1_2_8_21_1 doi: 10.1007/BF00054016 – ident: e_1_2_8_45_1 doi: 10.1073/pnas.87.11.4246 – volume: 54 start-page: 1882s year: 1994 ident: e_1_2_8_7_1 article-title: Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis publication-title: Cancer Res. contributor: fullname: Bowden G.T. – ident: e_1_2_8_37_1 doi: 10.1016/j.ccr.2007.03.009 – ident: e_1_2_8_25_1 doi: 10.1136/mp.50.6.289 – ident: e_1_2_8_50_1 doi: 10.1038/sj.onc.1207797 – ident: e_1_2_8_42_1 doi: 10.1016/0092-8674(95)90370-4 – ident: e_1_2_8_15_1 doi: 10.1038/nrc1209 – volume: 60 start-page: 400 year: 2000 ident: e_1_2_8_64_1 article-title: A dominant role for the c‐Jun NH2‐terminal kinase in oncogenic ras‐induced morphologic transformation of human lung carcinoma cells publication-title: Cancer Res. contributor: fullname: Xiao L. – ident: e_1_2_8_38_1 doi: 10.1016/S1097-2765(04)00153-4 – ident: e_1_2_8_16_1 doi: 10.1002/(SICI)1097-0029(19970815)38:4<343::AID-JEMT2>3.0.CO;2-K – volume: 19 start-page: 173 year: 2004 ident: e_1_2_8_48_1 article-title: Transcription factors involved in development and progression of malignant melanoma publication-title: Histol. Histopathol. contributor: fullname: Poser I. – volume: 72 start-page: 506 year: 1995 ident: e_1_2_8_52_1 article-title: Reduced alpha‐catenin and E‐cadherin expression in breast cancer publication-title: Lab. Invest. contributor: fullname: Rimm D.L. – ident: e_1_2_8_10_1 doi: 10.1038/371171a0 – ident: e_1_2_8_4_1 doi: 10.1002/j.1460-2075.1995.tb00301.x – ident: e_1_2_8_12_1 doi: 10.1016/S0092-8674(05)80058-3 – ident: e_1_2_8_14_1 doi: 10.1073/pnas.91.2.609 – ident: e_1_2_8_62_1 doi: 10.4161/cc.3.2.648 – ident: e_1_2_8_30_1 doi: 10.1083/jcb.130.1.67 – ident: e_1_2_8_53_1 doi: 10.1002/mc.2940100205 – ident: e_1_2_8_5_1 doi: 10.1128/MCB.20.10.3616-3625.2000 – volume: 3 start-page: 177 year: 1988 ident: e_1_2_8_20_1 article-title: bFGF as an autocrine growth factor for human melanomas publication-title: Oncogene Res. contributor: fullname: Halaban R. – volume: 1 start-page: 188 year: 1996 ident: e_1_2_8_22_1 article-title: Shifts in cadherin profiles between human normal melanocytes and melanomas publication-title: J. Investig. Dermatol. Symp. Proc. contributor: fullname: Hsu M.Y. – ident: e_1_2_8_44_1 doi: 10.1083/jcb.116.4.989 – ident: e_1_2_8_47_1 doi: 10.1038/sj.onc.1209114 – ident: e_1_2_8_33_1 doi: 10.1128/MCB.11.9.4466 – ident: e_1_2_8_29_1 doi: 10.1091/mbc.E08-12-1196 – ident: e_1_2_8_34_1 doi: 10.1038/sj.onc.1209054 – ident: e_1_2_8_39_1 doi: 10.1084/jem.20082044 – ident: e_1_2_8_59_1 doi: 10.1038/354494a0 – ident: e_1_2_8_35_1 doi: 10.1038/sj.onc.1207831 – ident: e_1_2_8_56_1 doi: 10.1038/sj.onc.1204383 – ident: e_1_2_8_6_1 doi: 10.1083/jcb.106.3.761 – ident: e_1_2_8_27_1 doi: 10.1074/jbc.270.28.16483 – ident: e_1_2_8_61_1 doi: 10.3109/15419069409014207 – ident: e_1_2_8_54_1 doi: 10.1073/pnas.85.22.8464 – ident: e_1_2_8_28_1 doi: 10.4161/cc.2.3.388 – ident: e_1_2_8_31_1 doi: 10.1128/MCB.20.2.575-582.2000 – ident: e_1_2_8_3_1 doi: 10.1126/science.2541502 – ident: e_1_2_8_43_1 doi: 10.1158/0008-5472.CAN-07-2938 – ident: e_1_2_8_58_1 doi: 10.1002/(SICI)1096-9896(199812)186:4<350::AID-PATH181>3.0.CO;2-K – ident: e_1_2_8_23_1 doi: 10.1016/S0002-9440(10)65023-7 – ident: e_1_2_8_18_1 doi: 10.1038/32918 – volume: 29 start-page: 373 year: 2007 ident: e_1_2_8_63_1 article-title: Expression of integrin alpha10 is induced in malignant melanoma publication-title: Cell. Oncol. contributor: fullname: Wenke A.K. – ident: e_1_2_8_19_1 doi: 10.1126/science.7824938 – ident: e_1_2_8_40_1 doi: 10.1034/j.1600-0625.2003.120310.x – ident: e_1_2_8_55_1 doi: 10.1136/mp.52.3.151 – ident: e_1_2_8_65_1 doi: 10.1016/S1534-5807(03)00161-8 – ident: e_1_2_8_49_1 doi: 10.1074/jbc.M011224200 – ident: e_1_2_8_9_1 doi: 10.1158/0008-5472.CAN-08-0041 – ident: e_1_2_8_26_1 doi: 10.1038/sj.onc.1204389 – ident: e_1_2_8_51_1 doi: 10.1038/353670a0 – ident: e_1_2_8_2_1 doi: 10.1128/MCB.25.20.9138-9150.2005 – ident: e_1_2_8_8_1 doi: 10.1038/337661a0 |
| SSID | ssj0060593 |
| Score | 2.1493537 |
| Snippet | Summary
A central event in the development of malignant melanoma is the loss of the tumor‐suppressor protein E‐cadherin. Here, we report that this loss is... A central event in the development of malignant melanoma is the loss of the tumor-suppressor protein E-cadherin. Here, we report that this loss is linked to... |
| SourceID | proquest crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 148 |
| SubjectTerms | c-Jun c-Jun protein Cadherins - metabolism Cell Adhesion Cell Line, Tumor Cytoskeleton Cytoskeleton - metabolism Data processing E-Cadherin Gene Expression Regulation, Neoplastic Humans malignant melanoma Melanocytes Melanoma Melanoma - enzymology Melanoma - genetics Melanoma - pathology Mitogen-Activated Protein Kinases - metabolism Pigments Post-transcription post-transcriptional regulation Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Proto-oncogenes Signal transduction Transcription Transcription factors Transcription, Genetic Translation Tumorigenesis |
| Title | Post-transcriptional regulation controlled by E-cadherin is important for c-Jun activity in melanoma |
| URI | https://api.istex.fr/ark:/67375/WNG-VF7RSCK8-Q/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1755-148X.2010.00787.x https://www.ncbi.nlm.nih.gov/pubmed/20977688 https://search.proquest.com/docview/1028075503 https://search.proquest.com/docview/840350313 |
| Volume | 24 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Zi9RAEC50RfDF-4gXLYhvkc7Rnc6jjDPKisu667H40vQJqzsZmQPWN3-Cv9FfYlVnMjiygohvCanOUefXneoqgMdB8rL11DRDRZ7XsfK5KaLJpW24K2JJkqeli8Nm70g9H1OZnN1hL0xfH2Kz4EaWkfw1Gbixi20jb4TIEc4fDRlaqHxPCU_ipCHt5qj2B6cseV9_dz2kKX5L6jnrRluR6gIx_fQsGLqNalNYmlz5nx90FS6vwSl71mvTNTgXuutw8eMsLb3fgE_U2ffHt-9Lim-Dt0H6ed_PHk_YOvP9JHhmv7IxEjvj0xZDdrxgx9OE9rslQ6jMHF7dXXWMtlZQBwuGRNNwYrrZ1NyEd5Px29HLfN2rIXcEaTDQIZaLdayLaD2CjKpyEZ2tkUqEtrBl5L71kUdXei5D5YUKynDl2ljXjZG8ugU73awLd4BZG_FctpYLV7vatlFYGZRwiJaMqEIGxSAX_aUvyaF_mcogDzXxUBMPdeKhPs3gSRLgZoCZf6aUtkboD3sv9PtJc3A4eqX0mwweDRLWaGj098R0YbZaaEJiiK8ErzJgf6DB2XIlqBpmBrd77dg8sOSItKVSGcikBH_96np_9PoAj-7-68B7cKlfCKccnPuws5yvwgM4v_Crh8lGfgIuFBGg |
| link.rule.ids | 315,782,786,1408,27935,27936,46066,46490 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Zb9QwELagFYIXbmg4jYR4C3LiI84jWnYpbLsqbYGqL5bjQyrtZtEeUnnjJ_Ab-SXMJJsVi4qEEG-JMs4xlz9PxjOEPA-K5aXHphk6slRE7lObRZuqqmAuizlKHkMXB8XoSL_uY5mcYbcXpq0PsQq4oWU0_hoNHAPS61ZeSJkCnj_qUrRA-14CoNwUSpTYx4Hzvc4tK9ZW4F2OKbLf0nouutPaXLWJbD-_CIiu49pmYhrc-K-fdJNcX-JT-qpVqFvkUqhvkyvHkyb6fod8xua-P759n-MU1zkcoJ-2Le3hhC6T38-Cp9VX2gdiZ32zy5CezOjJuAH89ZwCWqYOrr5b1BR3V2ATCwpE43Bm68nY3iUfBv3D3na6bNeQOkQ1MNcBnIsiiixWHnAG5y6Cv7VKy1BmVR6ZL31k0eWeqcC91EFbpl0ZhSisYvwe2agnddgitKoinKuyYtIJJ6oyykoFLR0AJit5SEjWCcZ8aatymF9WM8BDgzw0yEPT8NCcJ-RFI8HVADs9xay2QppPozfm46DYP-gNtXmfkGediA3YGv5AsXWYLGYGwRhALMl4QugfaGDBzCUWxEzI_VY9Vg_MGYBtpXVCVKMFf_3qZq-3uw9HD_514FNydftwd8fsvB0NH5JrbVwcU3IekY35dBEek8szv3jSGMxPXl8VwQ |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Zb9QwEB5BKxAvlJtQDiMh3oKcw47ziLa7QAurpeWoeLEcH1Khm632kMobP6G_sb-EmWSzYlGREOItUcY5Zjwzn505AJ55ydPSUdMMFXich8zFJgkmllXBbRJSkjxtXRwUw0O106cyObtdLkxbH2K14Uaa0dhrUvATF9aVvBAiRjh_2EVo4eR7gXhyMydUTukc2aizypK3BXiXY4rkt6iei-605qo2ieunF-HQdVjb-KXB1v_8ohtwfYlO2ct2Ot2ES76-BVe-TJq999vwlVr7nv84m5OD68wN0k_bhvZ4wpah78feseo76yOxNa7JMWRHM3Y0buB-PWeIlZnFq7uLmlFuBbWwYEg09semnozNHfg46H_ovY6XzRpiS5gGPR2CuZCHPAmVQ5SRZTagtTVSCV8mVRq4K13gwaaOS585obwyXNky5HlhJM_uwkY9qf19YFUV8FyWFRc2t3lVBlFJr4RFuGRE5iNIOrnok7Ymh_5lLYM81MRDTTzUDQ_1aQTPGwGuBpjpN4ppK4T-PHylPw2K_YPentLvI3jaSVijptHvE1P7yWKmCYohwBI8i4D9gQaXy5mgcpgR3Gtnx-qBKUeoLZWKQDaT4K9fXY967_bx6MG_DnwCV0c7A_32zXBvG661m-IUj_MQNubThX8El2du8bhRl58AdxRw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Post%E2%80%90transcriptional+regulation+controlled+by+E%E2%80%90cadherin+is+important+for+c%E2%80%90Jun+activity+in+melanoma&rft.jtitle=Pigment+cell+and+melanoma+research&rft.au=Spangler%2C+B.&rft.au=Vardimon%2C+L.&rft.au=Bosserhoff%2C+A.+K.&rft.au=Kuphal%2C+S.&rft.date=2011-02-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=1755-1471&rft.eissn=1755-148X&rft.volume=24&rft.issue=1&rft.spage=148&rft.epage=164&rft_id=info:doi/10.1111%2Fj.1755-148X.2010.00787.x&rft.externalDBID=10.1111%252Fj.1755-148X.2010.00787.x&rft.externalDocID=PCMR787 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1755-1471&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1755-1471&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1755-1471&client=summon |