IL-8 Dictates Glycosaminoglycan Binding and Stability of IL-18 in Cystic Fibrosis

Dysregulation of airway inflammation contributes to lung disease in cystic fibrosis (CF). Inflammation is mediated by inflammatory cytokines, including IL-8, which illustrates an increase in biological half-life and proinflammatory activity when bound to glycosaminoglycans (GAGs). The aim of this pr...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 184; no. 3; pp. 1642 - 1652
Main Authors:	Reeves, Emer P, Williamson, Michael, Byrne, Barry, Bergin, David A, Smith, Stephen G. J, Greally, Peter, O'Kennedy, Richard, O'Neill, Shane J, McElvaney, Noel G
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-02-2010
Subjects:	Adolescent Binding, Competitive - immunology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology Cell Line, Transformed Child Child, Preschool Cystic Fibrosis - immunology Cystic Fibrosis - metabolism Cystic Fibrosis - pathology Down-Regulation - immunology Glycosaminoglycans - chemistry Glycosaminoglycans - metabolism Humans Inflammation Mediators - chemistry Inflammation Mediators - metabolism Interleukin-18 - chemistry Interleukin-18 - metabolism Interleukin-8 - biosynthesis Interleukin-8 - physiology Jurkat Cells Protein Binding - immunology Protein Stability Up-Regulation - immunology
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