Cyclic vomiting syndrome: epidemiology, diagnosis, and treatment

• Published in: Clinical autonomic research Vol. 28; no. 2; pp. 203 - 209
• Main Authors: Bhandari, Sanjay, Jha, Pinky, Thakur, Abhishek, Kar, Abhipsa, Gerdes, Harrison, Venkatesan, Thangam
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2018; Springer Nature B.V
• Subjects: Antidepressive Agents - therapeutic use; Cardiology; Diabetes; Diagnosis; Endocrinology; Epidemiology; Fluid Therapy - methods; Gastroenterology; Headache; Humans; Medicine; Medicine & Public Health; Migraine; Migraine Disorders - diagnosis; Migraine Disorders - psychology; Migraine Disorders - therapy; Nausea; Nausea - diagnosis; Nausea - psychology; Nausea - therapy; Neurology; Ophthalmology; Patient Education as Topic - methods; Review; Risk Reduction Behavior; Treatment Outcome; Vomiting; Vomiting - diagnosis; Vomiting - psychology; Vomiting - therapy; Cyclic Vomiting Syndrome; Rome Criteria; Emetic Phase; Pediatric Disorders; Tricyclic Antidepressants (TCAs)
• ISSN: 0959-9851; 1619-1560
• DOI: 10.1007/s10286-018-0506-2

Cyclic-vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder characterized by recurrent episodes of nausea and vomiting. Although once thought to be a pediatric disorder, there has been a considerable increase in recognition of CVS in adults. The exact pathogenesis is unknown and several theories have been proposed. Migraine and CVS share a similar pathophysiology as suggested by several studies. Since there are no specific biomarkers available for this disorder, physicians should rely on Rome criteria for the diagnosis. Due to the lack of randomized control trials, the treatment of CVS is primarily empirical.