MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS

• Published in: Tumor biology Vol. 37; no. 5; pp. 6477 - 6483
• Main Authors: Fu, Xin, Cui, Yanfen, Yang, Shaobin, Xu, Yue, Zhang, Zicheng
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-05-2016; Springer Nature B.V
• Subjects: 3' Untranslated Regions; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; MicroRNAs - genetics; Original Article; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Proto-Oncogene Proteins p21(ras) - genetics; RNA Interference; KRAS; miR-613; MicroRNAs; Ovarian cancer
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1007/s13277-015-4507-7

MicroRNAs (miRNAs) play several important roles in carcinogenesis, and the dysregulation of miRNAs is associated with cancer progression. Little is known about the role of miR-613 in ovarian cancer. In the present study, we demonstrate that miR-613 expression is downregulated in human ovarian cancer cell lines and tissues. Additionally, miR-613 overexpression suppressed ovarian cancer cell proliferation, colony formation, and invasion. Furthermore, KRAS was identified as a target of miR-613. Reintroducing KRAS rescued the inhibitory effects exerted by miR-613 on ovarian cancer cell proliferation and invasion. Taken together, our findings suggest that miR-613 functions as a candidate tumor suppressor miRNA in ovarian cancer by directly targeting KRAS. To the best of our knowledge, this is the first study to show that miR-613 affects the proliferation and invasion of ovarian cancer.