Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation

Although peroxisome proliferator-activated receptor-γ (PPARγ) is thought to play a protective role in the vasculature, its cell-specific effect, particularly in resistance vessels, is poorly defined. Nitric oxide (NO) plays a major role in vascular biology in the brain. We examined the hypothesis th...

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Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Vol. 64; no. 5; pp. 1088 - 1093
Main Authors:	De Silva, T Michael, Modrick, Mary L, Ketsawatsomkron, Pimonrat, Lynch, Cynthia, Chu, Yi, Pelham, Christopher J, Sigmund, Curt D, Faraci, Frank M
Format:	Journal Article
Language:	English
Published:	United States 01-11-2014
Subjects:	Animals Arterioles - metabolism Cerebrovascular Circulation - physiology Female Humans Male Mice Mice, Mutant Strains Mice, Transgenic Muscle, Smooth, Vascular - physiology Nitric Oxide - metabolism PPAR gamma - genetics PPAR gamma - physiology rho-Associated Kinases - physiology Signal Transduction - physiology Vasodilation - physiology cerebral arteries small vessel disease nitric oxide microcirculation
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