Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection

• Published in: Gut and liver Vol. 12; no. 2; pp. 158 - 164
• Main Authors: Sung, Jihee, Kim, Nayoung, Lee, Jongchan, Hwang, Young-Jae, Kim, Hyoung Woo, Chung, Jung Wha, Kim, Jin-Wook, Lee, Dong Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) Editorial Office of Gut and Liver 01-03-2018; Gastroenterology Council for Gut and Liver; 거트앤리버 소화기연관학회협의회
• Subjects: Adult; Aged; atrophic; Female; gastric juice; Gastric Juice - chemistry; gastritis; Gastritis, Atrophic - epidemiology; Gastritis, Atrophic - microbiology; Gastritis, Atrophic - pathology; Helicobacter Infections - epidemiology; Helicobacter Infections - pathology; helicobacter pylori; Helicobacter pylori - isolation & purification; Humans; Hydrogen-Ion Concentration; intestinal metaplasia; Intestinal Mucosa - pathology; Male; Metaplasia; Middle Aged; Original; Pepsinogen A - analysis; Precancerous Conditions - pathology; Precancerous Conditions - physiopathology; Republic of Korea; Statistics as Topic; Stomach Neoplasms - prevention & control; 내과학; Republic of Korea; Helicobacter pylori; Gastritis, atrophic; Intestinal metaplasia; Gastric juice
• ISSN: 1976-2283; 2005-1212
• DOI: 10.5009/gnl17063

Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and
infection.
Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013.
, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1β levels were measured.
The mean pH of gastric juice was higher in the
-positive group (n=17) than that in the
-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH ＜3 (n=28) and pH ≥3 (n=18) groups,
was lower in the pH ＜3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007). The pH ≥3 group demonstrated AG and IM more frequently than the pH ＜3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1β levels between the two groups.
There is a relationship between chronic
infection and gastric juice pH ≥3, which may originate from AG and IM in the body.