Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

Autophagy is an evolutionarily conserved mechanism contributing to cell survival under stress conditions including nutrient and growth factor deprivation. Connections and cross-talk between cell death mechanisms and autophagy is under investigation. Here, we describe Atg3, an essential regulatory co...

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Bibliographic Details
Published in:	Apoptosis (London) Vol. 17; no. 8; pp. 810 - 820
Main Authors:	Oral, Ozlem, Oz-Arslan, Devrim, Itah, Zeynep, Naghavi, Atabak, Deveci, Remziye, Karacali, Sabire, Gozuacik, Devrim
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-08-2012 Springer Nature B.V
Subjects:	Amino Acid Motifs Amino Acid Sequence Autophagy Autophagy-Related Proteins Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Caspase 8 - metabolism Caspase Inhibitors Cell Biology Cell death Cell Survival Conserved Sequence Cycloheximide - pharmacology Enzymatic activity Humans Jurkat Cells Molecular Sequence Data Mortality Oligopeptides - pharmacology Oncology Original Paper Protein Synthesis Inhibitors - pharmacology Proteolysis Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - physiology Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Ubiquitin-Conjugating Enzymes - chemistry Ubiquitin-Conjugating Enzymes - metabolism Virology Caspase-8 TRAIL Cell survival TNF-α Death receptor Autophagy Apoptosis
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