Regenerative Potential of Stem and Progenitor Cells from Ischemic Testes of C57Bl/6 Mice in Culture and in the Model of Spermatogenesis Suppression Caused by Busulfan

The regenerative potential of stem and progenitor cells from ischemic testes of C57Bl/6 mice was studied in vitro (cell culture) and in vivo (mouse model of busulfan-induced suppression of spermatogenesis). Spermatogonial stem cells with phenotypes CD117 — CD90 + and CD51 — CD24 + CD52 + from ischem...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 162; no. 3; pp. 400 - 405
Main Authors:	Skurikhin, E. G., Pakhomova, A. V., Pershina, O. V., Ermolaeva, L. A., Ermakova, N. N., Krupin, V. A., Pan, E. S., Kudryashova, A. I., Rybalkina, O. Yu, Zhdanov, V. V., Goldberg, V. E., Dygai, A. M.
Format:	Journal Article
Language:	English
Published:	New York Springer US 2017 Springer Nature B.V
Subjects:	Animals Antigens, CD - genetics Biomedical and Life Sciences Biomedicine Busulfan Busulfan - toxicity CD45 antigen CD90 antigen Cell Biology Cell culture Cell Differentiation - drug effects Cell Proliferation - drug effects Cell self-renewal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Gene Expression Internal Medicine Ischemia Ischemia - metabolism Ischemia - pathology Laboratory Medicine Leydig cells Leydig Cells - drug effects Leydig Cells - metabolism Leydig Cells - pathology Ligation Male Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice Mice, Inbred C57BL Morphology and Pathomorphology Pathology Regeneration - drug effects Rodents Seminiferous Tubules - drug effects Seminiferous Tubules - metabolism Seminiferous Tubules - pathology Spermatic Cord - blood supply Spermatic Cord - surgery Spermatogenesis Spermatogenesis - drug effects Spermatogonia - drug effects Spermatogonia - metabolism Spermatogonia - pathology Stem Cell Transplantation Stem cells Testes Testosterone Testosterone - biosynthesis Tubules busulfan epithelial precursors spermatogonial stem cells endothelial precursors Sca-1 + cells
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