Effect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndrome

• Published in: Fertility and sterility Vol. 77; no. 3; p. 526
• Main Authors: Hacihanefioglu, Burak, Somunkiran, Asli, Mahmutoglu, Ismet, Sercelik, Alper, Toptani, Semra, Kervancioglu, Ertan
• Format: Journal Article
• Language: English
• Published: United States 01-03-2002
• Subjects: Adult; Androstenedione - blood; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Dehydroepiandrosterone Sulfate - blood; Estradiol - blood; Female; Gonadotropins - blood; Humans; Hyperandrogenism - blood; Hyperandrogenism - drug therapy; Hypertension - blood; Hypertension - complications; Hypertension - drug therapy; Lisinopril - pharmacology; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Progesterone - analogs & derivatives; Progesterone - blood; Prolactin - blood; Prospective Studies; Sex Hormone-Binding Globulin - metabolism; Testosterone - blood; Thyrotropin - blood
• ISSN: 0015-0282
• DOI: 10.1016/S0015-0282(01)03210-1

To investigate the effect of an angiotensin-converting enzyme inhibitor, lisinopril, on serum androgen and sex-hormone-binding globulin (SHBG) levels in hypertensive women with polycystic ovary syndrome (PCOS).
Prospective, observational study.
Infertility Clinic of the Sani Konukoglu Hospital, Gaziantep, Turkey.
Ten hypertensive women with PCOS.
Lisinopril, 10 mg/day, for 4 weeks. MAIN OUTCOME MEASURE(S)): Serum levels of gonadotropins, DHEAS, total T, free T, 17 alpha-hydroxyprogesterone (17-OHP), androstenedione, E2, SHBG, TSH, and PRL were determined.
Hypertension treatment with lisinopril (10 mg/day for 4 weeks) resulted in a statistically significant decrease in serum free T levels. However, there was no difference in the SHBG levels.
Use of lisinopril, an angiotensin-converting enzyme inhibitor, results in decreased free T levels independently of SHBG. It may affect the free T levels by affecting the ovarian renin-angiotensin system.