PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression

Chromatin regulators play an important role in the development of human diseases. In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently. PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei. Mutatio...

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Bibliographic Details
Published in:	Scientific reports Vol. 4; no. 1; p. 5008
Main Authors:	Wang, Juan, Lin, Xueqiu, Wang, Su, Wang, Chenfei, Wang, Qixuan, Duan, Xikun, Lu, Peng, Wang, Qian, Wang, Chengyang, Liu, X. Shirley, Huang, Jinyan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-05-2014 Nature Publishing Group
Subjects:	38/39 49/15 631/114/2163 631/208/177 Cells, Cultured Chromatin Chromatin - genetics Chromatin Immunoprecipitation DNA-directed RNA polymerase Gene expression Gene Expression Regulation Histone Demethylases - genetics Histone Demethylases - metabolism Humanities and Social Sciences Humans Immunoprecipitation Lysine multidisciplinary Nucleotide Motifs - genetics Plant diseases Promoter Regions, Genetic - genetics Promoters Repressor Proteins - genetics Repressor Proteins - metabolism REST protein RNA polymerase RNA Polymerase II - genetics RNA Polymerase II - metabolism Science Transcription Transcription Factors - genetics Transcription Factors - metabolism
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