Controlled trial of extradural bupivacaine with fentanyl, morphine or placebo for pain relief in labour

In a prospective, randomized double-blind study carried out on 255 parturients, fentanyl 80 micrograms (n = 81), morphine 4 mg (n = 83) or placebo (n = 85) was added to 0.25% bupivacaine administered extradurally for pain relief during labour. Fentanyl increased the mean duration of bupivacaine anal...

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Bibliographic Details
Published in:	British journal of anaesthesia : BJA Vol. 62; no. 6; p. 641
Main Authors:	Lirzin, J D, Jacquinot, P, Dailland, P, Jorrot, J C, Jasson, J, Talafre, M L, Conseiller, C
Format:	Journal Article
Language:	English
Published:	England 01-06-1989
Subjects:	Analgesia, Epidural Anesthesia, Obstetrical Bupivacaine Delivery, Obstetric Double-Blind Method Female Fentanyl Humans Labor, Obstetric Morphine Pregnancy Prospective Studies Random Allocation Time Factors
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Summary:	In a prospective, randomized double-blind study carried out on 255 parturients, fentanyl 80 micrograms (n = 81), morphine 4 mg (n = 83) or placebo (n = 85) was added to 0.25% bupivacaine administered extradurally for pain relief during labour. Fentanyl increased the mean duration of bupivacaine analgesia by 30% and did not reduce the rate of inadequate pain relief. Morphine did not increase the mean duration of bupivacaine analgesia significantly, but increased the rate of inadequate pain relief. It was concluded that morphine 4 mg added to extradural 0.25% bupivacaine was of no value.
ISSN:	0007-0912
DOI:	10.1093/bja/62.6.641