Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles

The purpose of this study was to modulate macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype using plasmid DNA (pDNA) expressing interleukin-4 (IL4) or interleukin-10 (IL10)-encapsulated in hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/p...

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Bibliographic Details
Published in:	Scientific reports Vol. 5; no. 1; p. 16632
Main Authors:	Tran, Thanh-Huyen, Rastogi, Ruchir, Shelke, Juili, Amiji, Mansoor M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-11-2015 Nature Publishing Group
Subjects:	13/21 14/19 42/41 42/44 59/5 631/61/2300/1514 692/308/153 96/1 96/31 Animals CD163 antigen CD44 antigen Cytokines Cytokines - metabolism Deoxyribonucleic acid DNA Gene Expression Genotype & phenotype Humanities and Social Sciences Hyaluronan Receptors - metabolism Hyaluronic acid Hyaluronic Acid - chemistry IL-1β Inflammation Mediators - metabolism Inflammatory diseases Interleukin 1 Interleukin 10 Interleukin 4 Interleukin-10 - genetics Interleukin-4 - genetics Lipopolysaccharides Macrophages Macrophages - immunology Macrophages - metabolism Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL multidisciplinary Nanoparticles Nanoparticles - chemistry Nitric-oxide synthase Peritoneal fluid Peritoneum Phenotype Phenotypes Plasmids - genetics Polarity Polyethyleneimine Rodents Science Transfection Tumor necrosis factor-α
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