Pitfalls in salicylate toxicity

To the Editor, We read with great interest the report by Drs Herres, Ryan, and Salzman entitled "Delayed Salicylate Toxicity With Undetectable Initial Levels After Large-dose Aspirin Ingestion" [1]. Once the patient becomes acidotic, the nonionized salicylate rapidly crosses the blood brai...

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Bibliographic Details
Published in:	The American journal of emergency medicine Vol. 28; no. 3; pp. 383 - 384
Main Authors:	Bora, Keenan, MD, Aaron, Cynthia, MD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2010 Elsevier Limited
Subjects:	Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - poisoning Aspirin - pharmacokinetics Aspirin - poisoning Blood Chemical Analysis Central nervous system Edema Emergency Emergency medical care Humans Hydrogen-Ion Concentration Ingestion Intubation Intubation, Intratracheal Laboratories Poisoning - blood Poisoning - diagnosis Respiration Toxicity Ventilation
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Summary:	To the Editor, We read with great interest the report by Drs Herres, Ryan, and Salzman entitled "Delayed Salicylate Toxicity With Undetectable Initial Levels After Large-dose Aspirin Ingestion" [1]. Once the patient becomes acidotic, the nonionized salicylate rapidly crosses the blood brain barrier where it can cause central nervous system acidosis leading to cerebral edema and seizures.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2
ISSN:	0735-6757 1532-8171
DOI:	10.1016/j.ajem.2009.12.003