Toxicity and genotoxicity evaluation of Passiflora alata Curtis (Passifloraceae)

An Passiflora alata aerial parts extract (2.4% total flavonoids) induces DNA damage assessed by comet assay in mice peripheral blood leukocytes. Passiflora alata is an official species of Brazilian Pharmacopoeia and its aerial parts are used as medicinal plant by local population as well as constitu...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 128; no. 2; pp. 526 - 532
Main Authors:	Boeira, Jane M., Fenner, Raquel, Betti, Andresa H., Provensi, Gustavo, Lacerda, Luciana de A., Barbosa, Patrícia R., González, Félix H.D., Corrêa, André M.R., Driemeier, David, Dall’Alba, Marília P., Pedroso, Annelise P., Gosmann, Grace, da Silva, Juliana, Rates, Stela M.K.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 24-03-2010 Amsterdam; New York: Elsevier Elsevier
Subjects:	acute toxicity adverse effects animal behavior animal models Animals Biological and medical sciences biomarkers bone marrow Bone Marrow Cells - drug effects Brazil Comet Assay DNA Damage dosage dose response Flavonoids - pharmacology Flavonoids - toxicity General pharmacology Genotoxicity hematology histopathology Hypnotics and Sedatives - pharmacology Hypnotics and Sedatives - toxicity leukocytes Male Medical sciences medicinal plants medicinal properties Mice Mice, Inbred Strains Micronucleus Tests mortality Passiflora Passiflora - toxicity Passiflora alata Passifloraceae Passifloraceae - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - toxicity Rats Rats, Wistar signs and symptoms (animals and humans) subacute toxicity Toxicity traditional medicine urine Water - pharmacology Brazil Passiflora Passiflora alata Toxicity Genotoxicity Evaluation Passifloraceae Pharmacognosy Medicinal plant Dicotyledones DNA Angiospermae Plant origin Spermatophyta
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